Dearnaley, D., Griffin, C.L., Lewis, R., Mayles, P., Mayles, H., Naismith, O.F., Harris, V., Scrase, C.D., Staffurth, J., Syndikus, I., et al.
(2019). Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL). International journal of radiation oncology*biology*physics,
Walker, A.K., Karaszi, K., Valentine, H., Strauss, V.Y., Choudhury, A., McGill, S., Wen, K., Brown, M.D., Ramani, V., Bhattarai, S., et al.
(2019). MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer. International journal of radiation oncology*biology*physics,
Wilkins, A., Stuttle, C., Hassan, S., Blanchard, C., Cruickshank, C., Griffin, C., Probert, J., Corbishley, C.M., Parker, C., Dearnaley, D., et al.
(2018). Methodology for tissue sample collection within a translational sub-study of the CHHiP trial (CRUK/06/016), a large randomised phase III trial in localised prostate cancer. Clinical and translational radiation oncology,
Wilson, J.M., Dearnaley, D.P., Syndikus, I., Khoo, V., Birtle, A., Bloomfield, D., Choudhury, A., Graham, J., Ferguson, C., Malik, Z., et al.
(2018). The Efficacy and Safety of Conventional and Hypofractionated High-Dose Radiation Therapy for Prostate Cancer in an Elderly Population: A Subgroup Analysis of the CHHiP Trial. International journal of radiation oncology*biology*physics,
Hague, C., Foran, B., Hall, E., Guild, S., Joseph, O., Moule, R., Nutting, C., Parsons, S., Prestwich, R., Slevin, N., et al.
(2018). Patient Involvement in the Design of a Phase III Trial Comparing Intensity-modulated Proton Therapy and Intensity-modulated Radiotherapy for Oropharyngeal Cancer. Clinical oncology,
Wilkins, A.C., Gusterson, B., Szijgyarto, Z., Haviland, J., Griffin, C., Stuttle, C., Daley, F., Corbishley, C.M., Dearnaley, D.P., Hall, E., et al.
(2018). Ki67 Is an Independent Predictor of Recurrence in the Largest Randomized Trial of 3 Radiation Fractionation Schedules in Localized Prostate Cancer. International journal of radiation oncology*biology*physics,
Nutting, C.M., Morden, J.P., Beasley, M., Bhide, S., Cook, A., De Winton, E., Emson, M., Evans, M., Fresco, L., Gollins, S., et al.
(2018). Results of a multicentre randomised controlled trial of cochlear-sparing intensity-modulated radiotherapy versus conventional radiotherapy in patients with parotid cancer (COSTAR; CRUK/08/004). European journal of cancer,
Choudhury, A., West, C.M., Porta, N., Hall, E., Denley, H., Hendron, C., Lewis, R., Hussain, S.A., Huddart, R. & James, N., et al.
(2017). The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004). British journal of cancer,
Dearnaley, D., Syndikus, I., Mossop, H., Khoo, V., Birtle, A., Bloomfield, D., Graham, J., Kirkbride, P., Logue, J., Malik, Z., et al.
(2016). Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. The lancet oncology,
Harris, V.A., Staffurth, J., Naismith, O., Esmail, A., Gulliford, S., Khoo, V., Lewis, R., Littler, J., McNair, H., Sadoyze, A., et al.
(2015). Consensus Guidelines and Contouring Atlas for Pelvic Node Delineation in Prostate and Pelvic Node Intensity Modulated Radiation Therapy. International journal of radiation oncology*biology*physics,
Wilkins, A., Mossop, H., Syndikus, I., Khoo, V., Bloomfield, D., Parker, C., Logue, J., Scrase, C., Patterson, H., Birtle, A., et al.
(2015). Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. The lancet oncology,
Mateo, J., Carreira, S., Sandhu, S., Miranda, S., Mossop, H., Perez-Lopez, R., Rodrigues, D.N., Robinson, D., Omlin, A., Tunariu, N., et al.
(2015). DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. The new england journal of medicine,
James, N.D., Hussain, S.A., Hall, E., Jenkins, P., Tremlett, J., Rawlings, C., Crundwell, M., Sizer, B., Sreenivasan, T., Hendron, C., et al.
(2012). Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N engl j med,
BACKGROUND: Radiotherapy is an alternative to cystectomy in patients with muscle-invasive bladder cancer. In other disease sites, synchronous chemoradiotherapy has been associated with increased local control and improved survival, as compared with radiotherapy alone. METHODS: In this multicenter, phase 3 trial, we randomly assigned 360 patients with muscle-invasive bladder cancer to undergo radiotherapy with or without synchronous chemotherapy. The regimen consisted of fluorouracil (500 mg per square meter of body-surface area per day) during fractions 1 to 5 and 16 to 20 of radiotherapy and mitomycin C (12 mg per square meter) on day 1. Patients were also randomly assigned to undergo either whole-bladder radiotherapy or modified-volume radiotherapy (in which the volume of bladder receiving full-dose radiotherapy was reduced) in a partial 2-by-2 factorial design (results not reported here). The primary end point was survival free of locoregional disease. Secondary end points included overall survival and toxic effects. RESULTS: At 2 years, rates of locoregional disease-free survival were 67% (95% confidence interval [CI], 59 to 74) in the chemoradiotherapy group and 54% (95% CI, 46 to 62) in the radiotherapy group. With a median follow-up of 69.9 months, the hazard ratio in the chemoradiotherapy group was 0.68 (95% CI, 0.48 to 0.96; P=0.03). Five-year rates of overall survival were 48% (95% CI, 40 to 55) in the chemoradiotherapy group and 35% (95% CI, 28 to 43) in the radiotherapy group (hazard ratio, 0.82; 95% CI, 0.63 to 1.09; P=0.16). Grade 3 or 4 adverse events were slightly more common in the chemoradiotherapy group than in the radiotherapy group during treatment (36.0% vs. 27.5%, P=0.07) but not during follow-up (8.3% vs. 15.7%, P=0.07). CONCLUSIONS: Synchronous chemotherapy with fluorouracil and mitomycin C combined with radiotherapy significantly improved locoregional control of bladder cancer, as compared with radiotherapy alone, with no significant increase in adverse events. (Funded by Cancer Research U.K.; BC2001 Current Controlled Trials number, ISRCTN68324339.)..
Sharma, R.A., Plummer, R., Stock, J.K., Greenhalgh, T.A., Ataman, O., Kelly, S., Clay, R., Adams, R.A., Baird, R.D., Billingham, L., et al.
Clinical development of new drug-radiotherapy combinations. Nat rev clin oncol,
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments. Notably, around 40% of cancer cures include the use of radiotherapy, either as a single modality or combined with other treatments. Radiotherapy can provide enormous benefit to patients with cancer. In the past decade, significant technical advances, such as image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic radiotherapy, and proton therapy enable higher doses of radiotherapy to be delivered to the tumour with significantly lower doses to normal surrounding tissues. However, apart from the combination of traditional cytotoxic chemotherapy with radiotherapy, little progress has been made in identifying and defining optimal targeted therapy and radiotherapy combinations to improve the efficacy of cancer treatment. The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) formed a Joint Working Group with representatives from academia, industry, patient groups and regulatory bodies to address this lack of progress and to publish recommendations for future clinical research. Herein, we highlight the Working Group's consensus recommendations to increase the number of novel drugs being successfully registered in combination with radiotherapy to improve clinical outcomes for patients with cancer..
Systematic review of methodology used in clinical studies evaluating the benefits of proton beam therapy Clinical and Translational Radiation Oncology. Clinical and translational radiation oncology,
Hall, E., Brand, D., Tree, A., Ostler, P., van der Voet, H., Loblaw, A., Chu, W., Ford, D., Tolan, S., Jain, S., et al.
Intensity Modulated Fractionated Radiotherapy Versus Stereotactic Body Radiotherapy for Prostate Cancer (PACE-B): Acute Toxicity Results From a Randomised Open-label Phase III Non-inferiority Trial. The lancet oncology,