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Jenkins, L. Jungwirth, U. Avgustinova, A. Iravani, M. Mills, A. Haider, S. Harper, J. Isacke, C.M. (2022). Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade. , Vol.82 (16), pp. 2904-2917.  show abstract

Rätze, M.A. Koorman, T. Sijnesael, T. Bassey-Archibong, B. van de Ven, R. Enserink, L. Visser, D. Jaksani, S. Viciano, I. Bakker, E.R. Richard, F. Tutt, A. O'Leary, L. Fitzpatrick, A. Roca-Cusachs, P. van Diest, P.J. Desmedt, C. Daniel, J.M. Isacke, C.M. Derksen, P.W. (2022). Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer. Oncogene, .  show abstract

Gui, G. Panopoulou, E. Tang, S. Twelves, D. Kabir, M. Ward, A. Montgomery, C. Nerurkar, A. Osin, P. Isacke, C.M. (2021). The INTEND 1 randomized controlled trial of duct endoscopy as an indicator of margin excision in breast conservation surgery. Breast cancer research and treatment, Vol.186 (3), pp. 723-730.

Jungwirth, U. van Weverwijk, A. Evans, R.J. Jenkins, L. Vicente, D. Alexander, J. Gao, Q. Haider, S. Iravani, M. Isacke, C.M. (2021). Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis. Nature communications, Vol.12 (1), pp. 3516-?.  show abstract

Fitzpatrick, A. Iravani, M. Mills, A. Childs, L. Alaguthurai, T. Clifford, A. Garcia-Murillas, I. Van Laere, S. Dirix, L. Harries, M. Okines, A. Turner, N.C. Haider, S. Tutt, A.N. Isacke, C.M. (2021). Assessing CSF ctDNA to improve diagnostic accuracy and therapeutic monitoring in breast cancer leptomeningeal metastasis. Clinical cancer research : an official journal of the american association for cancer research, .  show abstract

Sflomos, G. Schipper, K. Koorman, T. Fitzpatrick, A. Oesterreich, S. Lee, A.V. Jonkers, J. Brunton, V.G. Christgen, M. Isacke, C. Derksen, P.W. Brisken, C. (2021). Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions. Cancers (basel), Vol.13 (21).  show abstract

Koundouros, N. Karali, E. Tripp, A. Valle, A. Inglese, P. Perry, N.J. Magee, D.J. Anjomani Virmouni, S. Elder, G.A. Tyson, A.L. Dória, M.L. van Weverwijk, A. Soares, R.F. Isacke, C.M. Nicholson, J.K. Glen, R.C. Takats, Z. Poulogiannis, G. (2020). Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell, Vol.181 (7), pp. 1596-1611.e27.  show abstract

Wagner, S. Vlachogiannis, G. De Haven Brandon, A. Valenti, M. Box, G. Jenkins, L. Mancusi, C. Self, A. Manodoro, F. Assiotis, I. Robinson, P. Chauhan, R. Rust, A.G. Matthews, N. Eason, K. Khan, K. Starling, N. Cunningham, D. Sadanandam, A. Isacke, C.M. Kirkin, V. Valeri, N. Whittaker, S.R. (2019). Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer. Oncogene, Vol.38 (10), pp. 1717-1733.  show abstract

Kijewska, M. Viski, C. Turrell, F. Fitzpatrick, A. van Weverwijk, A. Gao, Q. Iravani, M. Isacke, C.M. (2019). Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain. Breast cancer research : bcr, Vol.21 (1), pp. 4-?.  show abstract

van Weverwijk, A. Koundouros, N. Iravani, M. Ashenden, M. Gao, Q. Poulogiannis, G. Jungwirth, U. Isacke, C.M. (2019). Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation. Nature communications, Vol.10 (1), pp. 2698-?.  show abstract

Gui, G. Agusti, A. Twelves, D. Tang, S. Kabir, M. Montgomery, C. Nerurkar, A. Osin, P. Isacke, C. (2018). INTEND II randomized clinical trial of intraoperative duct endoscopy in pathological nipple discharge. The british journal of surgery, Vol.105 (12), pp. 1583-1590.  show abstract

Ashenden, M. van Weverwijk, A. Murugaesu, N. Fearns, A. Campbell, J. Gao, Q. Iravani, M. Isacke, C.M. (2017). An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer. Molecular cancer therapeutics, Vol.16 (9), pp. 1967-1978.  show abstract

Thway, K. Robertson, D. Jones, R.L. Selfe, J. Shipley, J. Fisher, C. Isacke, C.M. (2016). Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells. British journal of cancer, Vol.115 (4), pp. 473-479.  show abstract

Locard-Paulet, M. Lim, L. Veluscek, G. McMahon, K. Sinclair, J. van Weverwijk, A. Worboys, J.D. Yuan, Y. Isacke, C.M. Jørgensen, C. (2016). Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration. Science signaling, Vol.9 (414).  show abstract

Andreucci, E. Francica, P. Fearns, A. Martin, L.-. Chiarugi, P. Isacke, C.M. Morandi, A. (2016). Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts. Oncotarget, Vol.7 (49), pp. 80543-80553.  show abstract

Bacci, M. Giannoni, E. Fearns, A. Ribas, R. Gao, Q. Taddei, M.L. Pintus, G. Dowsett, M. Isacke, C.M. Martin, L.-. Chiarugi, P. Morandi, A. (2016). miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors. Cancer research, Vol.76 (6), pp. 1615-1626.  show abstract

Viski, C. König, C. Kijewska, M. Mogler, C. Isacke, C.M. Augustin, H.G. (2016). Endosialin-Expressing Pericytes Promote Metastatic Dissemination. Cancer res, Vol.76 (18), pp. 5313-5325.  show abstract

Avgustinova, A. Iravani, M. Robertson, D. Fearns, A. Gao, Q. Klingbeil, P. Hanby, A.M. Speirs, V. Sahai, E. Calvo, F. Isacke, C.M. (2016). Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nature communications, Vol.7, pp. 10305-?.  show abstract

Soady, K.J. Kendrick, H. Gao, Q. Tutt, A. Zvelebil, M. Ordonez, L.D. Quist, J. Tan, D.W. Isacke, C.M. Grigoriadis, A. Smalley, M.J. (2015). Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Breast cancer research : bcr, Vol.17, pp. 31-?.  show abstract

McFarlane, S. Coulter, J.A. Tibbits, P. O'Grady, A. McFarlane, C. Montgomery, N. Hill, A. McCarthy, H.O. Young, L.S. Kay, E.W. Isacke, C.M. Waugh, D.J. (2015). CD44 increases the efficiency of distant metastasis of breast cancer. Oncotarget, Vol.6 (13), pp. 11465-11476.

Smith, S.W. Croft, A.P. Morris, H.L. Naylor, A.J. Huso, D.L. Isacke, C.M. Savage, C.O. Buckley, C.D. (2015). Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis. Nephron, Vol.131 (4), pp. 265-277.  show abstract

Murugaesu, N. Iravani, M. van Weverwijk, A. Ivetic, A. Johnson, D.A. Antonopoulos, A. Fearns, A. Jamal-Hanjani, M. Sims, D. Fenwick, K. Mitsopoulos, C. Gao, Q. Orr, N. Zvelebil, M. Haslam, S.M. Dell, A. Yarwood, H. Lord, C.J. Ashworth, A. Isacke, C.M. (2014). An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor. Cancer discov, Vol.4 (3), pp. 304-317.  show abstract

Isacke, C.M. Barcellos-Hoff, M.H. (2014). Soil Amendments That Slow Cancer Growth. Cancer discovery, Vol.4 (6), pp. 637-639.

Morandi, A. Isacke, C.M. (2014). Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in breast cancer. Breast cancer res, Vol.16 (1), p. 301.  show abstract

Twelves, D. Nerurkar, A. Osin, P. Ward, A. Isacke, C.M. Gui, G.P. (2013). The feasibility of nipple aspiration and duct lavage to evaluate the breast duct epithelium of women with increased breast cancer risk. Eur j cancer, Vol.49 (1), pp. 65-71.  show abstract

Twelves, D. Nerurkar, A. Osin, P. Dexter, T. Ward, A. Gui, G.P. Isacke, C.M. (2013). DNA promoter hypermethylation profiles in breast duct fluid. Breast cancer res treat, Vol.139 (2), pp. 341-350.  show abstract

Morandi, A. Martin, L.-. Gao, Q. Pancholi, S. Mackay, A. Robertson, D. Zvelebil, M. Dowsett, M. Plaza-Menacho, I. Isacke, C.M. (2013). GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors. Cancer research, Vol.73 (12), pp. 3783-3795.  show abstract

Lax, S. Ross, E.A. White, A. Marshall, J.L. Jenkinson, W.E. Isacke, C.M. Huso, D.L. Cunningham, A.F. Anderson, G. Buckley, C.D. (2012). CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. Febs open bio, Vol.2 (1), pp. 187-190.

Lopez-Guisa, J.M. Cai, X. Collins, S.J. Yamaguchi, I. Okamura, D.M. Bugge, T.H. Isacke, C.M. Emson, C.L. Turner, S.M. Shankland, S.J. Eddy, A.A. (2012). Mannose Receptor 2 Attenuates Renal Fibrosis. Journal of the american society of nephrology, Vol.23 (2), pp. 236-251.

Sarrio, D. Franklin, C.K. Mackay, A. Reis-Filho, J.S. Isacke, C.M. (2012). Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem cells, Vol.30 (2), pp. 292-303.  show abstract

Twelves, D. Nerurkar, A. Osin, P. Ward, A. Isacke, C.M. Gui, G.P. (2012). The anatomy of fluid-yielding ducts in breast cancer. Breast cancer res treat, Vol.132 (2), pp. 555-564.  show abstract

Iorns, E. Ward, T.M. Dean, S. Jegg, A. Thomas, D. Murugaesu, N. Sims, D. Mitsopoulos, C. Fenwick, K. Kozarewa, I. Naceur-Lombarelli, C. Zvelebil, M. Isacke, C.M. Lord, C.J. Ashworth, A. Hnatyszyn, H.J. Pegram, M. Lippman, M. (2012). Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor. Breast cancer res treat, Vol.135 (1), pp. 79-91.  show abstract

Naylor, A.J. Azzam, E. Smith, S. Croft, A. Poyser, C. Duffield, J.S. Huso, D.L. Gay, S. Ospelt, C. Cooper, M.S. Isacke, C. Goodyear, S.R. Rogers, M.J. Buckley, C.D. (2012). The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. Arthritis and rheumatism, Vol.64 (10), pp. 3334-3343.

Sartelet, A. Klingbeil, P. Franklin, C.K. Fasquelle, C. Geron, S. Isacke, C.M. Georges, M. Charlier, C. (2012). Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection?. Animal genetics, Vol.43 (5), pp. 604-607.

Simonavicius, N. Ashenden, M. van Weverwijk, A. Lax, S. Huso, D.L. Buckley, C.D. Huijbers, I.J. Yarwood, H. Isacke, C.M. (2012). Pericytes promote selective vessel regression to regulate vascular patterning. Blood, Vol.120 (7), pp. 1516-1527.  show abstract

Angeles Castilla, M. Diaz-Martin, J. Sarrio, D. Romero-Perez, L. Angeles Lopez-Garcia, M. Vieites, B. Biscuola, M. Ramiro-Fuentes, S. Isacke, C.M. Palacios, J. (2012). MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes. Plos one, Vol.7 (10).

Henry, L.A. Johnson, D.A. Sarrió, D. Lee, S. Quinlan, P.R. Crook, T. Thompson, A.M. Reis-Filho, J.S. Isacke, C.M. (2011). Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome. Oncogene, Vol.30 (9), pp. 1046-1058.  show abstract

Morandi, A. Plaza-Menacho, I. Isacke, C.M. (2011). RET in breast cancer: functional and therapeutic implications. Trends mol med, Vol.17 (3), pp. 149-157.  show abstract

Tang, S.S. Twelves, D.J. Isacke, C.M. Gui, G.P. (2011). Mammary ductoscopy in the current management of breast disease. Surg endosc, Vol.25 (6), pp. 1712-1722.  show abstract

Hardie, D.L. Baldwin, M.J. Naylor, A. Haworth, O.J. Hou, T.Z. Lax, S. Curnow, S.J. Willcox, N. MacFadyen, J. Isacke, C.M. Buckley, C.D. (2011). The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation. Immunology, Vol.133 (3), pp. 288-295.  show abstract

Smith, S.W. Eardley, K.S. Croft, A.P. Nwosu, J. Howie, A.J. Cockwell, P. Isacke, C.M. Buckley, C.D. Savage, C.O. (2011). CD248+ stromal cells are associated with progressive chronic kidney disease. Kidney int, Vol.80 (2), pp. 199-207.  show abstract

Plaza-Menacho, I. Morandi, A. Mologni, L. Boender, P. Gambacorti-Passerini, C. Magee, A.I. Hofstra, R.M. Knowles, P. McDonald, N.Q. Isacke, C.M. (2011). Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J biol chem, Vol.286 (19), pp. 17292-17302.  show abstract

Klingbeil, P. Isacke, C.M. (2011). The 'alternative' EMT switch. Breast cancer res, Vol.13 (4), p. 313.  show abstract

Sims, D. Mendes-Pereira, A.M. Frankum, J. Burgess, D. Cerone, M.-. Lombardelli, C. Mitsopoulos, C. Hakas, J. Murugaesu, N. Isacke, C.M. Fenwick, K. Assiotis, I. Kozarewa, I. Zvelebil, M. Ashworth, A. Lord, C.J. (2011). High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing. Genome biol, Vol.12 (10), p. R104.  show abstract

Westbury, C.B. Sahlberg, K.K. Borresen-Dale, A.-. Isacke, C.M. Yarnold, J.R. (2011). Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients. Radiat oncol, Vol.6, p. 42.  show abstract

Robertson, D. Isacke, C.M. (2011). Multiple immunofluorescence labeling of formalin-fixed paraffin-embedded tissue. Methods mol biol, Vol.724, pp. 69-77.  show abstract

Klingbeil, P. Natrajan, R. Everitt, G. Vatcheva, R. Marchio, C. Palacios, J. Buerger, H. Reis-Filho, J.S. Isacke, C.M. (2010). CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification. Breast cancer res treat, Vol.120 (1), pp. 95-109.  show abstract

Lax, S. Hardie, D.L. Wilson, A. Douglas, M.R. Anderson, G. Huso, D. Isacke, C.M. Buckley, C.D. (2010). The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur j immunol, Vol.40 (7), pp. 1884-1889.  show abstract

Plaza-Menacho, I. Morandi, A. Robertson, D. Pancholi, S. Drury, S. Dowsett, M. Martin, L.-. Isacke, C.M. (2010). Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance. Oncogene, Vol.29 (33), pp. 4648-4657.  show abstract

Huijbers, I.J. Iravani, M. Popov, S. Robertson, D. Al-Sarraj, S. Jones, C. Isacke, C.M. (2010). A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. Plos one, Vol.5 (3), p. e9808.  show abstract

Watkins, N.A. Gusnanto, A. de Bono, B. De, S. Miranda-Saavedra, D. Hardie, D.L. Angenent, W.G. Attwood, A.P. Ellis, P.D. Erber, W. Foad, N.S. Garner, S.F. Isacke, C.M. Jolley, J. Koch, K. Macaulay, I.C. Morley, S.L. Rendon, A. Rice, K.M. Taylor, N. Thijssen-Timmer, D.C. Tijssen, M.R. van der Schoot, C.E. Wernisch, L. Winzer, T. Dudbridge, F. Buckley, C.D. Langford, C.F. Teichmann, S. Göttgens, B. Ouwehand, W.H. Bloodomics Consortium, (2009). A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood, Vol.113 (19), pp. e1-e9.  show abstract

Westbury, C.B. Reis-Filho, J.S. Dexter, T. Mahler-Araujo, B. Fenwick, K. Iravani, M. Grigoriadis, A. Parry, S. Robertson, D. Mackay, A. Ashworth, A. Yarnold, J.R. Isacke, C.M. (2009). Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation. J pathol, Vol.219 (1), pp. 131-140.  show abstract

Fasquelle, C. Sartelet, A. Li, W. Dive, M. Tamma, N. Michaux, C. Druet, T. Huijbers, I.J. Isacke, C.M. Coppieters, W. Georges, M. Charlier, C. (2009). Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle. Plos genet, Vol.5 (9), p. e1000666.  show abstract

Gui, G.P. Twelves, D. Nerurkar, A. Osin, P. Ward, A. Isacke, C.M. (2009). Anatomical association of fluid yielding ducts with location of the breast cancer affected segment in screen detected and symptomatic breast cancer. Bmc proceedings, Vol.3 (S5).

Gui, G.P. Twelves, D. Nerurkar, A. Osin, P. Ward, A. Crook, T. Isacke, C.M. (2009). A direct comparative study of methylation-specific PCR in ductal lavage fluid, breast cancer tissue, normal breast parenchyma and plasma in women with early breast cancer. Bmc proceedings, Vol.3 (S5).

Messaritou, G. East, L. Roghi, C. Isacke, C.M. Yarwood, H. (2009). Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. J cell sci, Vol.122 (Pt 22), pp. 4042-4048.  show abstract

Simonavicius, N. Robertson, D. Bax, D.A. Jones, C. Huijbers, I.J. Isacke, C.M. (2008). Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod pathol, Vol.21 (3), pp. 308-315.  show abstract

Robertson, D. Savage, K. Reis-Filho, J.S. Isacke, C.M. (2008). Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue. Bmc cell biol, Vol.9, p. 13.  show abstract

MacFadyen, J. Savage, K. Wienke, D. Isacke, C.M. (2007). Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene expr patterns, Vol.7 (3), pp. 363-369.  show abstract

Sleeman, K.E. Kendrick, H. Robertson, D. Isacke, C.M. Ashworth, A. Smalley, M.J. (2007). Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J cell biol, Vol.176 (1), pp. 19-26.  show abstract

Esseghir, S. Kennedy, A. Seedhar, P. Nerurkar, A. Poulsom, R. Reis-Filho, J.S. Isacke, C.M. (2007). Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. Clin cancer res, Vol.13 (11), pp. 3164-3173.  show abstract

Wienke, D. Davies, G.C. Johnson, D.A. Sturge, J. Lambros, M.B. Savage, K. Elsheikh, S.E. Green, A.R. Ellis, I.O. Robertson, D. Reis-Filho, J.S. Isacke, C.M. (2007). The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer res, Vol.67 (21), pp. 10230-10240.  show abstract

Plaza-Menacho, I. van der Sluis, T. Hollema, H. Gimm, O. Buys, C.H. Magee, A.I. Isacke, C.M. Hofstra, R.M. Eggen, B.J. (2007). Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation. J biol chem, Vol.282 (9), pp. 6415-6424.  show abstract

Plaza-Menacho, I. Mologni, L. Sala, E. Gambacorti-Passerini, C. Magee, A.I. Links, T.P. Hofstra, R.M. Barford, D. Isacke, C.M. (2007). Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J biol chem, Vol.282 (40), pp. 29230-29240.  show abstract

Noble, J. Dua, R.S. Locke, I. Eeles, R. Gui, G.P. Isacke, C.M. (2007). Proteomic analysis of nipple aspirate fluid throughout the menstrual cycle in healthy pre-menopausal women. Breast cancer res treat, Vol.104 (2), pp. 191-196.  show abstract

Sturge, J. Todd, S.K. Kogianni, G. McCarthy, A. Isacke, C.M. (2007). Mannose receptor regulation of macrophage cell migration. J leukoc biol, Vol.82 (3), pp. 585-593.  show abstract

Noble, J.L. Dua, R.S. Coulton, G.R. Isacke, C.M. Gui, G.P. (2007). A comparative proteinomic analysis of nipple aspiration fluid from healthy women and women with breast cancer. Eur j cancer, Vol.43 (16), pp. 2315-2320.  show abstract

Esseghir, S. Todd, S.K. Hunt, T. Poulsom, R. Plaza-Menacho, I. Reis-Filho, J.S. Isacke, C.M. (2007). A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer res, Vol.67 (24), pp. 11732-11741.  show abstract

Lax, S. Hou, T.Z. Jenkinson, E. Salmon, M. MacFadyen, J.R. Isacke, C.M. Anderson, G. Cunningham, A.F. Buckley, C.D. (2007). CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. Febs lett, Vol.581 (18), pp. 3550-3556.  show abstract

Dua, R.S. Isacke, C.M. Gui, G.P. (2006). The intraductal approach to breast cancer biomarker discovery. J clin oncol, Vol.24 (7), pp. 1209-1216.  show abstract

Paraskeva, P.A. Ridgway, P.F. Olsen, S. Isacke, C. Peck, D.H. Darzi, A.W. (2006). A surgically induced hypoxic environment causes changes in the metastatic behaviour of tumours in vitro. Clinical & experimental metastasis, Vol.23 (2), pp. 149-157.

Martinez-Pomares, L. Wienke, D. Stillion, R. McKenzie, E.J. Arnold, J.N. Harris, J. McGreal, E. Sim, R.B. Isacke, C.M. Gordon, S. (2006). Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. Eur j immunol, Vol.36 (5), pp. 1074-1082.  show abstract

Esseghir, S. Reis-Filho, J.S. Kennedy, A. James, M. O'Hare, M.J. Jeffery, R. Poulsom, R. Isacke, C.M. (2006). Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts. J pathol, Vol.210 (4), pp. 420-430.  show abstract

Honardoust, H.A. Jiang, G. Koivisto, L. Wienke, D. Isacke, C.M. Larjava, H. Häkkinen, L. (2006). Expression of Endo180 is spatially and temporally regulated during wound healing. Histopathology, Vol.49 (6), pp. 634-648.  show abstract

Sturge, J. Wienke, D. Isacke, C.M. (2006). Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J cell biol, Vol.175 (2), pp. 337-347.  show abstract

Tzircotis, G. Thorne, R.F. Isacke, C.M. (2006). Directional sensing of a phorbol ester gradient requires CD44 and is regulated by CD44 phosphorylation. Oncogene, Vol.25 (56), pp. 7401-7410.  show abstract

Boskovic, J. Arnold, J.N. Stilion, R. Gordon, S. Sim, R.B. Rivera-Calzada, A. Wienke, D. Isacke, C.M. Martinez-Pomares, L. Llorca, O. (2006). Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J biol chem, Vol.281 (13), pp. 8780-8787.  show abstract

Sleeman, K.E. Kendrick, H. Ashworth, A. Isacke, C.M. Smalley, M.J. (2006). CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast cancer res, Vol.8 (1), p. R7.  show abstract

Tzircotis, G. Thorne, R.F. Isacke, C.M. (2005). Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. J cell sci, Vol.118 (Pt 21), pp. 5119-5128.  show abstract

Zola, H. Swart, B. Nicholson, I. Aasted, B. Bensussan, A. Boumsell, L. Buckley, C. Clark, G. Drbal, K. Engel, P. Hart, D. Horejsi, V. Isacke, C. Macardle, P. Malavasi, F. Mason, D. Olive, D. Saalmueller, A. Schlossman, S.F. Schwartz-Albiez, R. Simmons, P. Tedder, T.F. Uguccioni, M. Warren, H. (2005). CD molecules 2005: human cell differentiation molecules. Blood, Vol.106 (9), pp. 3123-4.

MacFadyen, J.R. Haworth, O. Roberston, D. Hardie, D. Webster, M.-. Morris, H.R. Panico, M. Sutton-Smith, M. Dell, A. van der Geer, P. Wienke, D. Buckley, C.D. Isacke, C.M. (2005). Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. Febs lett, Vol.579 (12), pp. 2569-2575.  show abstract

Dua, R.S. Gui, G.P. Isacke, C.M. (2005). Endothelial adhesion molecules in breast cancer invasion into the vascular and lymphatic systems. Eur j surg oncol, Vol.31 (8), pp. 824-832.  show abstract

Thomas, E.K. Nakamura, M. Wienke, D. Isacke, C.M. Pozzi, A. Liang, P. (2005). Endo180 binds to the C-terminal region of type I collagen. J biol chem, Vol.280 (24), pp. 22596-22605.  show abstract

Buckley, C.D. Halder, S. Hardie, D. Reynolds, G. Torensma, R. De Villeroche, V.J. Brouty-Boye, D. Isacke, C.M. (2005). Report on antibodies submitted to the stromal cell section of HLDA8. Cell immunol, Vol.236 (1-2), pp. 29-41.  show abstract

Howard, M.J. Chambers, M.G. Mason, R.M. Isacke, C.M. (2004). Distribution of Endo180 receptor and ligand in developing articular cartilage. Osteoarthritis cartilage, Vol.12 (1), pp. 74-82.  show abstract

Tzircotis, G. Thorne, R.F. Isacke, C.M. (2004). A new spreadsheet method for the analysis of bivariate flow cytometric data. Bmc cell biol, Vol.5, p. 10.  show abstract

Thorne, R.F. Legg, J.W. Isacke, C.M. (2004). The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events. J cell sci, Vol.117 (Pt 3), pp. 373-380.  show abstract

Sullivan, A. Uff, C.R. Isacke, C.M. Thorne, R.F. (2003). PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. Exp cell res, Vol.284 (2), pp. 224-238.  show abstract

East, L. McCarthy, A. Wienke, D. Sturge, J. Ashworth, A. Isacke, C.M. (2003). A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. Embo rep, Vol.4 (7), pp. 710-716.  show abstract

Rivera-Calzada, A. Robertson, D. MacFadyen, J.R. Boskovic, J. Isacke, C.M. Llorca, O. (2003). Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. Embo rep, Vol.4 (8), pp. 807-812.  show abstract

Bailey, L. Wienke, D. Howard, M. Knäuper, V. Isacke, C.M. Murphy, G. (2002). Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. Biochem j, Vol.363 (Pt 1), pp. 67-72.  show abstract

Legg, J.W. Lewis, C.A. Parsons, M. Ng, T. Isacke, C.M. (2002). A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nat cell biol, Vol.4 (6), pp. 399-407.  show abstract

Isacke, C.M. Yarwood, H. (2002). The hyaluronan receptor, CD44. Int j biochem cell biol, Vol.34 (7), pp. 718-721.  show abstract

East, L. Isacke, C.M. (2002). The mannose receptor family. Biochim biophys acta, Vol.1572 (2-3), pp. 364-386.  show abstract

East, L. Rushton, S. Taylor, M.E. Isacke, C.M. (2002). Characterization of sugar binding by the mannose receptor family member, Endo180. J biol chem, Vol.277 (52), pp. 50469-50475.  show abstract

Howard, M.J. Isacke, C.M. (2002). The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. J biol chem, Vol.277 (35), pp. 32320-32331.  show abstract

Lewis, C.A. Townsend, P.A. Isacke, C.M. (2001). Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan. Biochem j, Vol.357 (Pt 3), pp. 843-850.  show abstract

Morrison, H. Sherman, L.S. Legg, J. Banine, F. Isacke, C. Haipek, C.A. Gutmann, D.H. Ponta, H. Herrlich, P. (2001). The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes & development, Vol.15 (8), pp. 968-980.  show abstract

Sheikh, H. Yarwood, H. Ashworth, A. Isacke, C.M. (2000). Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. J cell sci, Vol.113 ( Pt 6), pp. 1021-1032.  show abstract

Sheikh, H. Legg, J. Lewis, C. Peck, D. Isacke, C. (1998). Discrete Domains Within the Hyaluronan Receptor CD44 Regulate Membrane Localization and Cell Migration. Cell adhesion and communication, Vol.6 (2-3), pp. 149-156.

Legg, J.W. Isacke, C.M. (1998). Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44. Curr biol, Vol.8 (12), pp. 705-708.  show abstract

Peck, D. Isacke, C.M. (1998). Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. J cell sci, Vol.111 ( Pt 11), pp. 1595-1601.  show abstract

Peck, D. Isacke, C.M. (1996). CD44 phosphorylation regulates melanoma cell and fibroblast migration on, but not attachment to, a hyaluronan substratum. Curr biol, Vol.6 (7), pp. 884-890.  show abstract

Sheikh, H. Isacke, C.M. (1996). A di-hydrophobic Leu-Val motif regulates the basolateral localization of CD44 in polarized Madin-Darby canine kidney epithelial cells. J biol chem, Vol.271 (21), pp. 12185-12190.  show abstract

Uff, C.R. Neame, S.J. Isacke, C.M. (1995). Hyaluronan binding by CD44 is regulated by a phosphorylation-independent mechanism. Eur j immunol, Vol.25 (7), pp. 1883-1887.  show abstract

Wheatley, S.C. Isacke, C.M. (1995). Induction of a hyaluronan receptor, CD44, during embryonal carcinoma and embryonic stem cell differentiation. Cell adhes commun, Vol.3 (3), pp. 217-230.  show abstract

Neame, S.J. Uff, C.R. Sheikh, H. Wheatley, S.C. Isacke, C.M. (1995). CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, plasma membrane domains. J cell sci, Vol.108 ( Pt 9), pp. 3127-3135.  show abstract

Isacke, C.M. (1994). The role of the cytoplasmic domain in regulating CD44 function. J cell sci, Vol.107 ( Pt 9), pp. 2353-2359.

Neame, S.J. Isacke, C.M. (1993). The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent-insoluble cytoskeleton of fibroblasts. J cell biol, Vol.121 (6), pp. 1299-1310.  show abstract

Wheatley, S.C. Isacke, C.M. Crossley, P.H. (1993). Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning. Development, Vol.119 (2), pp. 295-306.  show abstract

Neame, S.J. Isacke, C.M. (1992). Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells. Embo j, Vol.11 (13), pp. 4733-4738.  show abstract

Isacke, C.M. van der Geer, P. Hunter, T. Trowbridge, I.S. (1990). p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol cell biol, Vol.10 (6), pp. 2606-2618.  show abstract

Isacke, C.M. van der Geer, P. Hunter, T. Trowbridge, I.S. (1990). p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Molecular and cellular biology, Vol.10 (6), pp. 2606-2618.  show abstract

Isacke, C.M. Lindberg, R.A. Hunter, T. (1989). Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids. Mol cell biol, Vol.9 (1), pp. 232-240.  show abstract

Isacke, C.M. Lindberg, R.A. Hunter, T. (1989). Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids. Molecular and cellular biology, Vol.9 (1), pp. 232-240.  show abstract

Hunter, T. Angel, P. Boyle, W.J. Chiu, R. Freed, E. Gould, K.L. Isacke, C.M. Karin, M. Lindberg, R.A. van der Geer, P. (1988). Targets for signal-transducing protein kinases. Cold spring harb symp quant biol, Vol.53 Pt 1, pp. 131-142.

Omary, M.B. Trowbridge, I.S. Letarte, M. Kagnoff, M.F. Isacke, C.M. (1988). Structural heterogeneity of human Pgp-1 and its relationship with p85. Immunogenetics, Vol.27 (6), pp. 460-464.

ISACKE, C.M. TROWBRIDGE, I.S. HUNTER, T. (1986). MODULATION OF P36 PHOSPHORYLATION IN HUMAN-CELLS. Journal of cellular biochemistry, , pp. 199-1.

Gould, K.L. Woodgett, J.R. Isacke, C.M. Hunter, T. (1986). The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. Mol cell biol, Vol.6 (7), pp. 2738-2744.  show abstract

Isacke, C.M. Trowbridge, I.S. Hunter, T. (1986). Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. Mol cell biol, Vol.6 (7), pp. 2745-2751.  show abstract

Gould, K.L. Woodgett, J.R. Isacke, C.M. Hunter, T. (1986). The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. Molecular and cellular biology, Vol.6 (7), pp. 2738-2744.  show abstract

Isacke, C.M. Trowbridge, I.S. Hunter, T. (1986). Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. Molecular and cellular biology, Vol.6 (7), pp. 2745-2751.  show abstract

Isacke, C.M. Meisenhelder, J. Brown, K.D. Gould, K.L. Gould, S.J. Hunter, T. (1986). Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide. Embo j, Vol.5 (11), pp. 2889-2898.  show abstract

Coussens, L. Van Beveren, C. Smith, D. Chen, E. Mitchell, R.L. Isacke, C.M. Verma, I.M. Ullrich, A. (1986). Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature, Vol.320 (6059), pp. 277-280.  show abstract

Isacke, C.M. Sauvage, C.A. Hyman, R. Lesley, J. Schulte, R. Trowbridge, I.S. (1986). Identification and characterization of the human Pgp-1 glycoprotein. Immunogenetics, Vol.23 (5), pp. 326-332.  show abstract

Heath, J.K. Isacke, C.M. (1984). PC13 embryonal carcinoma-derived growth factor. Embo j, Vol.3 (12), pp. 2957-2962.  show abstract

HEATH, J.K. ISACKE, C.M. (1983). RECIPROCAL CONTROL OF TERATOCARCINOMA PROLIFERATION. Cell biology international reports, Vol.7 (7), pp. 561-2.

Isacke, C.M. Deller, M.J. (1983). Teratocarcinoma cells exhibit growth cooperativity in vitro. J cell physiol, Vol.117 (3), pp. 407-414.  show abstract

Isacke, C.M. Heath, J.K. (1982). Modulation of dexamethasone receptor expression in embryonal carcinoma cells and their differentiated derivatives. Biochem j, Vol.208 (1), pp. 235-238.  show abstract

Soady, K.J. Tornillo, G. Kendrick, H. Meniel, V. Olijnyk-Dallis, D. Morris, J.S. Stein, T. Gusterson, B.A. Isacke, C.M. Smalley, M.J. Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development, .  show abstract

Jungwirth, U. van Weverwijk, A. Melake, M.J. Chambers, A.F. Gao, Q. Fivaz, M. Isacke, C.M. Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host. Disease models & mechanisms, .  show abstract

Evans, R.J. Perkins, D.W. Selfe, J. Kelsey, A. Birch, G.P. Shipley, J.M. Schipper, K. Isacke, C.M. Endo180 (MRC2) antibody-drug conjugate for the treatment of sarcoma. Molecular cancer therapeutics, .  show abstract


Isacke, C.M. Horton, M. (2000). The Adhesion Molecule FactsBook, 2nd ed.Academic Press.

Book Chapters

Heath, J.K. Isacke, C.M. (1983). The secretion of growth regulatory molecules by PC13 embryonal carcinoma cells. Hormonally defined media: A tool in cell biology. (pp. 109-6). Springer-Verlag, Heidelberg.