Professor Alessandro Vannini studied Biology at the University of Rome "Roma Tre" and undertook his Ph.D. research at IRBM "P. Angeletti" (Merck Research Lab), Rome, focussing on the structural characterisation of quorum-sensing proteins in pathogenic bacteria and of human histone-deacetylases (HDACs).
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For his post-doctoral research, supported by Marie-Curie and EMBO long-term fellowships he elucidated the architecture of yeast RNA polymerase III, the largest among the three eukaryotic RNA polymerases, combining X-ray crystallography and cryo-electron microscopy.
In 2012, Professor Vannini joined the ICR as Team Leader in the Division of Structural Biology. He and his team are focusing on the structural and functional characterisation of large macromolecular complexes that assemble at RNA polymerase III -transcribed genes across the eukaryotic genome.
Professor Vannini was elected EMBO Young Investigator in 2015 and received tenure and was awarded with the title of Reader in 2017. He was then made Deputy Head in the Division of Structural Biology in January 2019 and subsequently gained the title of Professor in October 2019.
In 2019, Professor Vannini was appointed Director of the Centre for Structural Biology at the Human Technopole Institute in Milan, while maintaining his lab and affiliation at the ICR.