Gani, C.
Boeke, S.
McNair, H.
Ehlers, J.
Nachbar, M.
Mönnich, D.
Stolte, A.
Boldt, J.
Marks, C.
Winter, J.
Künzel, L.A.
Gatidis, S.
Bitzer, M.
Thorwarth, D.
Zips, D.
(2021). Marker-less online MR-guided stereotactic body radiotherapy of liver metastases at a 1 5 T MR-Linac – Feasibility, workflow data and patient acceptance. Clinical and translational radiation oncology,
Vol.26,
pp. 55-61.
Townend, C.
Landeg, S.
Thorne, R.
Kirby, A.M.
McNair, H.A.
(2020). A review of permanent marking for radiotherapy in the UK. Radiography,
Vol.26
(1),
pp. 9-14.
Tan, M.P.
Harris, V.
Warren-Oseni, K.
McDonald, F.
McNair, H.
Taylor, H.
Hansen, V.
Sharabiani, M.
Thomas, K.
Jones, K.
Dearnaley, D.
Hafeez, S.
Huddart, R.A.
(2020). The Intensity-Modulated Pelvic Node and Bladder Radiotherapy (IMPART) Trial: A Phase II Single-Centre Prospective Study. Clinical oncology,
Vol.32
(2),
pp. 93-100.
Murray, J.R.
Tree, A.C.
Alexander, E.J.
Sohaib, A.
Hazell, S.
Thomas, K.
Gunapala, R.
Parker, C.C.
Huddart, R.A.
Gao, A.
Truelove, L.
McNair, H.A.
Blasiak-Wal, I.
deSouza, N.M.
Dearnaley, D.
(2020). Standard and Hypofractionated Dose Escalation to Intraprostatic Tumor Nodules in Localized Prostate Cancer: Efficacy and Toxicity in the DELINEATE Trial. International journal of radiation oncology*biology*physics,
Vol.106
(4),
pp. 715-724.
Barnes, H.
Mohajer, J.
Dunlop, A.
Adair Smith, G.
Herbert, T.
Lawes, R.
Tree, A.
McNair, H.
(2020). Laser-free pelvic alignment in an online adaptive radiotherapy environment. Technical innovations & patient support in radiation oncology,
Vol.13,
pp. 21-23.
Dunlop, A.
Mitchell, A.
Tree, A.
Barnes, H.
Bower, L.
Chick, J.
Goodwin, E.
Herbert, T.
Lawes, R.
McNair, H.
McQuaid, D.
Mohajer, J.
Nilawar, R.
Pathmanathan, A.
Smith, G.
Hanson, I.
Nill, S.
Oelfke, U.
(2020). Daily adaptive radiotherapy for patients with prostate cancer using a high field MR-linac: Initial clinical experiences and assessment of delivered doses compared to a C-arm linac. Clinical and translational radiation oncology,
Vol.23,
pp. 35-42.
Goldsworthy, S.
Palmer, S.
Latour, J.M.
McNair, H.
Cramp, M.
(2020). A systematic review of effectiveness of interventions applicable to radiotherapy that are administered to improve patient comfort, increase patient compliance, and reduce patient distress or anxiety. Radiography,
Vol.26
(4),
pp. 314-324.
Hunt, A.
Hanson, I.
Dunlop, A.
Barnes, H.
Bower, L.
Chick, J.
Cruickshank, C.
Hall, E.
Herbert, T.
Lawes, R.
McQuaid, D.
McNair, H.
Mitchell, A.
Mohajer, J.
Morgan, T.
Oelfke, U.
Smith, G.
Nill, S.
Huddart, R.
Hafeez, S.
(2020). Feasibility of magnetic resonance guided radiotherapy for the treatment of bladder cancer. Clinical and translational radiation oncology,
Vol.25,
pp. 46-51.
Goldsworthy, S.
Zheng, C.Y.
McNair, H.
McGregor, A.
(2020). The potential for haptic touch technology to supplement human empathetic touch during radiotherapy. Journal of medical imaging and radiation sciences,
Vol.51
(4),
pp. S39-S43.
Eccles, C.L.
Nill, S.
Herbert, T.
Scurr, E.
McNair, H.A.
(2019). Blurring the lines for better visualisation. Radiography,
Vol.25
(1),
pp. 91-93.
Goldsworthy, S.
McNair, H.
Dogramadzi, S.
(2019). Motion Capture Pillow (MCP): A novel method to improve comfort and accuracy in radiotherapy. Clinical medicine,
Vol.19
(Suppl 2),
pp. s103-s103.
Pathmanathan, A.U.
McNair, H.A.
Schmidt, M.A.
Brand, D.H.
Delacroix, L.
Eccles, C.L.
Gordon, A.
Herbert, T.
van As, N.J.
Huddart, R.A.
Tree, A.C.
(2019). Comparison of prostate delineation on multimodality imaging for MR-guided radiotherapy. Br j radiol,
Vol.92
(1095),
pp. 20180948-20180948.
show abstract
OBJECTIVE:: With increasing incorporation of MRI in radiotherapy, we investigate two MRI sequences for prostate delineation in radiographer-led image guidance. METHODS:: Five therapeutic radiographers contoured the prostate individually on CT, T2 weighted (T2W) and T2* weighted (T2*W) imaging for 10 patients. Contours were analysed with Monaco ADMIRE (research v. 2.0) to assess interobserver variability and accuracy by comparison with a gold standard clinician contour. Observers recorded time taken for contouring and scored image quality and confidence in contouring. RESULTS:: There is good agreement when comparing radiographer contours to the gold-standard for all three imaging types with Dice similarity co-efficient 0.91-0.94, Cohen's κ 0.85-0.91, Hausdorff distance 4.6-7.6 mm and mean distance between contours 0.9-1.2 mm. In addition, there is good concordance between radiographers across all imaging modalities. Both T2W and T2*W MRI show reduced interobserver variability and improved accuracy compared to CT, this was statistically significant for T2*W imaging compared to CT across all four comparison metrics. Comparing MRI sequences reveals significantly reduced interobserver variability and significantly improved accuracy on T2*W compared to T2W MRI for DSC and Cohen's κ. Both MRI sequences scored significantly higher compared to CT for image quality and confidence in contouring, particularly T2*W. This was also reflected in the shorter time for contouring, measuring 15.4, 9.6 and 9.8 min for CT, T2W and T2*W MRI respectively. Conclusion: Therapeutic radiographer prostate contours are more accurate, show less interobserver variability and are more confidently and quickly outlined on MRI compared to CT, particularly using T2*W MRI. Advances in knowledge: Our work is relevant for MRI sequence choice and development of the roles of the interprofessional team in the advancement of MRI-guided radiotherapy..
Mason, S.A.
White, I.M.
O'Shea, T.
McNair, H.A.
Alexander, S.
Kalaitzaki, E.
Bamber, J.C.
Harris, E.J.
Lalondrelle, S.
(2019). Combined Ultrasound and Cone Beam CT Improves Target Segmentation for Image Guided Radiation Therapy in Uterine Cervix Cancer. International journal of radiation oncology*biology*physics,
Vol.104
(3),
pp. 685-693.
Patel, E.
Tsang, Y.
Baker, A.
Callender, J.
Hafeez, S.
Hall, E.
Hansen, V.N.
Lewis, R.
McNair, H.
Miles, E.
Huddart, R.
(2019). Quality assuring “Plan of the day” selection in a multicentre adaptive bladder trial: Implementation of a pre-accrual IGRT guidance and assessment module. Clinical and translational radiation oncology,
Vol.19,
pp. 27-32.
Alexander, S.E.
Hopkins, N.
Lalondrelle, S.
Taylor, A.
Titmarsh, K.
McNair, H.A.
(2019). RTT-led IGRT for cervix cancer; training, implementation and validation. Technical innovations & patient support in radiation oncology,
Vol.12,
pp. 41-49.
Eccles, C.L.
Adair Smith, G.
Bower, L.
Hafeez, S.
Herbert, T.
Hunt, A.
McNair, H.A.
Ofuya, M.
Oelfke, U.
Nill, S.
Huddart, R.A.
(2019). Magnetic resonance imaging sequence evaluation of an MR Linac system; early clinical experience. Technical innovations & patient support in radiation oncology,
Vol.12,
pp. 56-63.
McNair, H.
Buijs, M.
(2019). Image guided radiotherapy moving towards real time adaptive radiotherapy; global positioning system for radiotherapy?. Technical innovations & patient support in radiation oncology,
Vol.12,
pp. 1-2.
White, I.
McQuaid, D.
McNair, H.
Dunlop, A.
Court, S.
Hopkins, N.
Thomas, K.
Dearnaley, D.
Bhide, S.
Lalondrelle, S.
(2019). Geometric and dosimetric evaluation of the differences between rigid and deformable registration to assess interfraction motion during pelvic radiotherapy. Physics and imaging in radiation oncology,
Vol.9,
pp. 97-102.
Grimwood, A.
McNair, H.A.
O'Shea, T.P.
Gilroy, S.
Thomas, K.
Bamber, J.C.
Tree, A.C.
Harris, E.J.
(2018). In Vivo Validation of Elekta's Clarity Autoscan for Ultrasound-based Intrafraction Motion Estimation of the Prostate During Radiation Therapy. International journal of radiation oncology*biology*physics,
Vol.102
(4),
pp. 912-921.
Alexander, S.E.
Kinsella, J.
McNair, H.A.
Tree, A.C.
(2018). National survey of fiducial marker insertion for prostate image guided radiotherapy. Radiography,
Vol.24
(4),
pp. 275-282.
Bartlett, F.R.
Donovan, E.M.
McNair, H.A.
Corsini, L.A.
Colgan, R.M.
Evans, P.M.
Maynard, L.
Griffin, C.
Haviland, J.S.
Yarnold, J.R.
Kirby, A.M.
(2017). The UK HeartSpare Study (Stage II): Multicentre Evaluation of a Voluntary Breath-hold Technique in Patients Receiving Breast Radiotherapy. Clinical oncology,
Vol.29
(3),
pp. e51-e56.
Hafeez, S.
McDonald, F.
Lalondrelle, S.
McNair, H.
Warren-Oseni, K.
Jones, K.
Harris, V.
Taylor, H.
Khoo, V.
Thomas, K.
Hansen, V.
Dearnaley, D.
Horwich, A.
Huddart, R.
(2017). Clinical Outcomes of Image Guided Adaptive Hypofractionated Weekly Radiation Therapy for Bladder Cancer in Patients Unsuitable for Radical Treatment. International journal of radiation oncology*biology*physics,
Vol.98
(1),
pp. 115-122.
Eccles, C.L.
McNair, H.A.
Armstrong, S.E.
Helyer, S.J.
Scurr, E.D.
(2017). In response to Westbrook – Opening the debate on MRI practitioner education. Radiography,
Vol.23,
pp. S75-S76.
Hafeez, S.
Warren-Oseni, K.
McNair, H.A.
Hansen, V.N.
Jones, K.
Tan, M.
Khan, A.
Harris, V.
McDonald, F.
Lalondrelle, S.
Mohammed, K.
Thomas, K.
Thompson, A.
Kumar, P.
Dearnaley, D.
Horwich, A.
Huddart, R.
(2016). Prospective Study Delivering Simultaneous Integrated High-dose Tumor Boost (≤70 Gy) With Image Guided Adaptive Radiation Therapy for Radical Treatment of Localized Muscle-Invasive Bladder Cancer. International journal of radiation oncology*biology*physics,
Vol.94
(5),
pp. 1022-1030.
Kember, S.A.
Hansen, V.N.
Fast, M.F.
Nill, S.
McDonald, F.
Ahmed, M.
Thomas, K.
McNair, H.A.
(2016). Evaluation of three presets for four-dimensional cone beam CT in lung radiotherapy verification by visual grading analysis. Br j radiol,
Vol.89
(1063),
pp. 20150933-20150933.
show abstract
OBJECTIVE: To evaluate three image acquisition presets for four-dimensional cone beam CT (CBCT) to identify an optimal preset for lung tumour image quality while minimizing dose and acquisition time. METHODS: Nine patients undergoing radical conventionally fractionated radiotherapy for lung cancer had verification CBCTs acquired using three presets: Preset 1 on Day 1 (11 mGy dose, 240 s acquisition time), Preset 2 on Day 2 (9 mGy dose, 133 s acquisition time) and Preset 3 on Day 3 (9 mGy dose, 67 s acquisition time). The clarity of the tumour and other thoracic structures, and the acceptability of the match, were retrospectively graded by visual grading analysis (VGA). Logistic regression was used to identify the most appropriate preset and any factors that might influence the result. RESULTS: Presets 1 and 2 met a clinical requirement of 75% of structures to be rated "Clear" or above and 75% of matches to be rated "Acceptable" or above. Clarity is significantly affected by preset, patient, observer and structure. Match acceptability is significantly affected by preset. CONCLUSION: The application of VGA in this initial study enabled a provisional selection of an optimal preset (Preset 2) to be made. ADVANCES IN KNOWLEDGE: This was the first application of VGA to the investigation of presets for CBCT..
Landeg, S.J.
Kirby, A.M.
Lee, S.F.
Bartlett, F.
Titmarsh, K.
Donovan, E.
Griffin, C.L.
Gothard, L.
Locke, I.
McNair, H.A.
(2016). A randomized control trial evaluating fluorescent ink versus dark ink tattoos for breast radiotherapy. Br j radiol,
Vol.89
(1068),
pp. 20160288-20160288.
show abstract
OBJECTIVE: The purpose of this UK study was to evaluate interfraction reproducibility and body image score when using ultraviolet (UV) tattoos (not visible in ambient lighting) for external references during breast/chest wall radiotherapy and compare with conventional dark ink. METHODS: In this non-blinded, single-centre, parallel group, randomized control trial, patients were allocated to receive either conventional dark ink or UV ink tattoos using computer-generated random blocks. Participant assignment was not masked. Systematic (∑) and random (σ) setup errors were determined using electronic portal images. Body image questionnaires were completed at pre-treatment, 1 month and 6 months to determine the impact of tattoo type on body image. The primary end point was to determine that UV tattoo random error (σsetup) was no less accurate than with conventional dark ink tattoos, i.e. <2.8 mm. RESULTS: 46 patients were randomized to receive conventional dark or UV ink tattoos. 45 patients completed treatment (UV: n = 23, dark: n = 22). σsetup for the UV tattoo group was <2.8 mm in the u and v directions (p = 0.001 and p = 0.009, respectively). A larger proportion of patients reported improvement in body image score in the UV tattoo group compared with the dark ink group at 1 month [56% (13/23) vs 14% (3/22), respectively] and 6 months [52% (11/21) vs 38% (8/21), respectively]. CONCLUSION: UV tattoos were associated with interfraction setup reproducibility comparable with conventional dark ink. Patients reported a more favourable change in body image score up to 6 months following treatment. Advances in knowledge: This study is the first to evaluate UV tattoo external references in a randomized control trial..
Kaza, E.
Collins, D.
Symonds-Tayler, R.
McDonald, F.
Scurr, E.
McNair, H.
Hansen, V.
Leach, M.
(2015). 143: Magnetic resonance imaging (MRI) in patients with non-small cell lung cancer (NSCLC) using active breathing coordinator motion control. Lung cancer,
Vol.87,
pp. S52-S52.
Bartlett, F.R.
Colgan, R.M.
Donovan, E.M.
McNair, H.A.
Carr, K.
Evans, P.M.
Griffin, C.
Locke, I.
Haviland, J.S.
Yarnold, J.R.
Kirby, A.M.
(2015). The UK HeartSpare Study (Stage IB): Randomised comparison of a voluntary breath-hold technique and prone radiotherapy after breast conserving surgery. Radiotherapy and oncology,
Vol.114
(1),
pp. 66-72.
Hudson, J.
Doolan, C.
McDonald, F.
Locke, I.
Ahmed, M.
Gunapala, G.
McNair, H.
(2015). Are therapeutic radiographers able to achieve clinically acceptable verification for stereotactic lung radiotherapy treatment (SBRT)?. Journal of radiotherapy in practice,
Vol.14
(1),
pp. 10-17.
show abstract
AbstractPurposeThe aim of this study was to assess the feasibility of radiographer led verification of cone-beam computed tomography (CBCT) images for patients with solitary lung tumours treated with stereotactic body radiotherapy treatment (SBRT).Material and methodsCBCT setup images of 20 patients from the first fraction of each patient were retrospectively registered by therapeutic radiographers. The displacements recorded were compared with the clinical oncologist’s original online match. The time taken by radiographers to verify the CBCT images was also recorded.ResultsOverall agreement for all radiographers when compared with the clinical oncologist match was 91%. Interobserver variations between radiographers were X plane 0·87 (0·76–0·94); Y plane 0·74 (0·51–0·88); and Z plane 0·88 (0·78–0·95) intraclass correlation coefficient and 95% confidence interval. The average time taken for verification was 128 seconds.ConclusionTherapeutic radiographers are able to verify CBCT images for thorax SBRT with results comparable to the ‘gold standard’ clinical oncologists’ match, however additional training will be provided for online verification. The time taken was within acceptable limits..
McNair, H.A.
Hafeez, S.
Taylor, H.
Lalondrelle, S.
McDonald, F.
Hansen, V.N.
Huddart, R.
(2015). Radiographer-led plan selection for bladder cancer radiotherapy: initiating a training programme and maintaining competency. The british journal of radiology,
Vol.88
(1048),
pp. 20140690-20140690.
Probst, H.
Harris, R.
McNair, H.A.
Baker, A.
Miles, E.A.
Beardmore, C.
(2015). Research from therapeutic radiographers: An audit of research capacity within the UK. Radiography,
Vol.21
(2),
pp. 112-118.
Harris, V.A.
Staffurth, J.
Naismith, O.
Esmail, A.
Gulliford, S.
Khoo, V.
Lewis, R.
Littler, J.
McNair, H.
Sadoyze, A.
Scrase, C.
Sohaib, A.
Syndikus, I.
Zarkar, A.
Hall, E.
Dearnaley, D.
(2015). Consensus Guidelines and Contouring Atlas for Pelvic Node Delineation in Prostate and Pelvic Node Intensity Modulated Radiation Therapy. International journal of radiation oncology*biology*physics,
Vol.92
(4),
pp. 874-883.
McNair, H.A.
Harris, E.J.
Hansen, V.N.
Thomas, K.
South, C.
Hafeez, S.
Huddart, R.
Dearnaley, D.P.
(2015). Magnitude of observer error using cone beam CT for prostate interfraction motion estimation: effect of reducing scan length or increasing exposure. The british journal of radiology,
Vol.88
(1054),
pp. 20150208-20150208.
Lacey, C.
Ockwell, C.
Locke, I.
Thomas, K.
Hendry, J.
McNair, H.
(2015). A prospective study comparing radiographer- and clinician-based localization for patients with metastatic spinal cord compression (MSCC) to assess the feasibility of a radiographer-led service. The british journal of radiology,
Vol.88
(1055),
pp. 20150586-20150586.
Kaza, E.
Symonds-Tayler, R.
Collins, D.J.
McDonald, F.
McNair, H.A.
Scurr, E.
Koh, D.-.
Leach, M.O.
(2015). First MRI application of an active breathing coordinator. Physics in medicine and biology,
Vol.60
(4),
pp. 1681-1696.
Yeoh, K.-.
McNair, H.A.
McDonald, F.
Hawkins, M.
Hansen, V.N.
Ramos, M.
Fragkandrea, I.
Bothwell, S.
Herbert, T.
Taylor, H.
Helyer, S.
Ashley, S.
Brada, M.
(2014). Cone beam CT verification for active breathing control (ABC)-gated radiotherapy for lung cancer. Acta oncologica,
Vol.53
(5),
pp. 716-719.
McNair, H.A.
Elsworthy, M.
Dean, J.
Beardmore, C.
(2014). Image guided radiotherapy: Current status of soft tissue imaging. Radiography,
Vol.20
(2),
pp. 158-161.
Hafeez, S.
McNair, H.
Warren-Oseni, K.
Hansen, V.
Huddart, R.
(2014). Audit of Radiographer Led Plan Selection in Imaged Guided Adaptive Radiotherapy (IGART) for Bladder Cancer. Clinical oncology,
Vol.26,
pp. S7-S8.
McNair, H.A.
Wedlake, L.
Lips, I.M.
Andreyev, J.
Van Vulpen, M.
Dearnaley, D.
(2014). A systematic review: Effectiveness of rectal emptying preparation in prostate cancer patients. Practical radiation oncology,
Vol.4
(6),
pp. 437-447.
Rosenfelder, N.A.
Corsini, L.
McNair, H.
Pennert, K.
Burke, K.
Lamb, C.M.
Aitken, A.
Ashley, S.
Khoo, V.
Brada, M.
(2013). Achieving the Relocation Accuracy of Stereotactic Frame-based Cranial Radiotherapy in a Three-point Thermoplastic Shell. Clinical oncology,
Vol.25
(1),
pp. 66-73.
Lee, Y.K.
Bedford, J.L.
McNair, H.A.
Hawkins, M.A.
(2013). Comparison of deliverable IMRT and VMAT for spine metastases using a simultaneous integrated boost. The british journal of radiology,
Vol.86
(1022),
pp. 20120466-20120466.
Rosenfelder, N.A.
Corsini, L.
McNair, H.
Pennert, K.
Aitken, A.
Lamb, C.M.
Long, M.
Clarke, E.
Murcia, M.
Schick, U.
Burke, K.
Ashley, S.
Khoo,, V.
Brada, M.
(2013). Comparison of setup accuracy and intrafraction motion using stereotactic frame versus 3-point thermoplastic mask-based immobilization for fractionated cranial image guided radiation therapy. Practical radiation oncology,
Vol.3
(3),
pp. 171-179.
Bartlett, F.R.
Colgan, R.M.
Carr, K.
Donovan, E.M.
McNair, H.A.
Locke, I.
Evans, P.M.
Haviland, J.S.
Yarnold, J.R.
Kirby, A.M.
(2013). The UK HeartSpare Study: Randomised evaluation of voluntary deep-inspiratory breath-hold in women undergoing breast radiotherapy. Radiotherapy and oncology,
Vol.108
(2),
pp. 242-247.
McDonald, F.
Lalondrelle, S.
Taylor, H.
Warren-Oseni, K.
Khoo, V.
McNair, H.A.
Harris, V.
Hafeez, S.
Hansen, V.N.
Thomas, K.
Jones, K.
Dearnaley, D.
Horwich, A.
Huddart, R.
(2013). Clinical Implementation of Adaptive Hypofractionated Bladder Radiotherapy for Improvement in Normal Tissue Irradiation. Clinical oncology,
Vol.25
(9),
pp. 549-556.
McNair, H.A.
Wedlake, L.
Shaw, C.
Andreyev, J.
Dearnaley, D.
(2013). Recording a patient diet over the radical course of radiotherapy for prostate cancer using a diet diary: a feasibility study. Journal of radiotherapy in practice,
Vol.12
(3),
pp. 281-282.
Mcnair, H.A.
Kavanagh, A.
Powell, C.
Symonds-Tayler, J.R.
Brada, M.
Evans, P.M.
(2012). Fluoroscopy as a surrogate for lung tumour motion. The british journal of radiology,
Vol.85
(1010),
pp. 168-175.
Brock, J.
Bedford, J.
Partridge, M.
McDonald, F.
Ashley, S.
McNair, H.A.
Brada, M.
(2012). Optimising Stereotactic Body Radiotherapy for Non-small Cell Lung Cancer with Volumetric Intensity-modulated Arc Therapy—A Planning Study. Clinical oncology,
Vol.24
(1),
pp. 68-75.
Buettner, F.
Alexander, E.
McNair, H.
Bulbrook, L.
Gulliford, S.
Partridge, M.
Dearnaley, D.
(2012). SU-E-T-255: A Novel Rectal Obturator for Prostate Radiotherapy Improves the Spatial Distribution of Dose and Reduces the Predicted Risk for Rectal Bleeding and Subjective Sphincter Control. Med phys,
Vol.39
(6Part13),
p. 3762.
show abstract
PURPOSE: To investigate the effects of an endorectal device during prostate radiotherapy on the spatial distribution of dose to the ano-rectal region and quantify implications for normal-tissue-complication probabilities. METHODS: Twenty-three patients with localised prostate cancer, referred for external beam radiotherapy had 2 CT scans acquired, without and with the rectal obturator (ProSpare) in-situ. For each patient two dose distributions were generated, based on both CT scans. Dose-surface maps for the rectal surface and the anal surface were generated and mean dose as well as a spatial measure (circumference of the dose distribution) were determined for all patients, with and without ProSpare. Using previously published NTCP models, the effect of ProSpare on NTCP was investigated for rectal bleeding and subjective sphincter control. RESULTS: In a previous study subjective sphincter control correlated strongest with mean dose and lateral extent at 53 Gy. The use of ProSpare resulted in a highly significant reduction of the lateral extent at 53 Gy (p=0.006), mean dose (p=0.0009) and NTCP according to the LKB model (p=0.002 for grade 2 and p=0.001 for grade >=1). In a previous study we reported that rectal bleeding correlated most strongly with the lateral extent at 55 Gy and presented the constraint that it should not exceed 42% of the circumference. Using ProSpare resulted in a significant reduction of the lateral extent at 55 Gy (p=0.001) and significantly more patients met that proposed constraint (p=0.047). ProSpare resulted in a significant reduction of NTCP for grade-2 rectal bleeding (p=0.007) and a reduction for rectal bleeding grade >=1 (p=0.053). CONCLUSIONS: ProSpare resulted in a significant reduction of mean dose to the anal sphincter and a significant reduction of the lateral extent at 55 Gy. This corresponded to a significant reduction in the predicted risk of reporting subjective sphincter control and grade-2 rectal bleeding..
d’Aquino, A.
Harrison, S.
Helyer, S.
Dearnaley, D.
McNair, H.
(2012). Set-up accuracy of an external immobilisation system for patients receiving radical radiotherapy for prostate cancer. Journal of radiotherapy in practice,
Vol.11
(3),
pp. 155-161.
show abstract
AbstractPurpose: To evaluate the accuracy of an external immobilisation system in patients receiving radiotherapy for prostate cancer.Methods: Portal Imaging data were audited in 20 patients treated using an in-house immobilisation system and 20 patients treated using an indexed commercial immobilisation system (Combifix™). Individual and group random and systematic errors were calculated to determine the accuracy of set-up using skin marks alone and with a no-action-level protocol.Results: The initial results showed a larger systematic error in the Combifix™ in the anterior-posterior direction (2.7 mm) compared with the in-house system (1.5 mm). The possible source of this was identified as the difficulty in accurately aligning the laser to a curved couch top prior to setting the isocentre height. A change in the process of setting the isocentre was introduced, and comparable baseline set-up accuracy was achieved. This was with a systematic error of ≤2.0 mm and a random error ≤1.5 mm of patient position set-up error with skin marks alone, and using the Combifix™. The systematic errors were further reduced to <1 mm with an off-line no-action-level protocol.Conclusion: Using the Combifix™ system a high level of set-up accuracy was reproduced in routine daily practice..
Franks, K.N.
McNair, H.A.
(2012). Implementation of Image-guided Radiotherapy. Clinical oncology,
Vol.24
(9),
pp. 625-626.
Lalondrelle, S.
Huddart, R.
Warren-Oseni, K.
Hansen, V.N.
McNair, H.
Thomas, K.
Dearnaley, D.
Horwich, A.
Khoo, V.
(2011). Adaptive-predictive organ localization using cone-beam computed tomography for improved accuracy in external beam radiotherapy for bladder cancer. Int j radiat oncol biol phys,
Vol.79
(3),
pp. 705-712.
show abstract
To examine patterns of bladder wall motion during high-dose hypofractionated bladder radiotherapy and to validate a novel adaptive planning method, A-POLO, to prevent subsequent geographic miss..
Hawkins, M.A.
Aitken, A.
Hansen, V.N.
McNair, H.A.
Tait, D.M.
(2011). Set-up errors in radiotherapy for oesophageal cancers – Is electronic portal imaging or conebeam more accurate?. Radiotherapy and oncology,
Vol.98
(2),
pp. 249-254.
Boda-Heggemann, J.
Fleckenstein, J.
Lohr, F.
Wertz, H.
Nachit, M.
Blessing, M.
Stsepankou, D.
Löb, I.
Küpper, B.
Kavanagh, A.
Hansen, V.N.
Brada, M.
Wenz, F.
McNair, H.
(2011). Multiple breath-hold CBCT for online image guided radiotherapy of lung tumors: Simulation with a dynamic phantom and first patient data. Radiotherapy and oncology,
Vol.98
(3),
pp. 309-316.
McNair, H.A.
Wedlake, L.
McVey, G.P.
Thomas, K.
Andreyev, J.
Dearnaley, D.P.
(2011). Can diet combined with treatment scheduling achieve consistency of rectal filling in patients receiving radiotherapy to the prostate?. Radiother oncol,
.
show abstract
BACKGROUND AND PURPOSE: This pilot study investigates whether an individualized fluid and fibre prescription combined with a constant treatment can improve rectal filling consistency during radiotherapy. METHODS AND MATERIALS: Fibre, fluid intake and bowel function were assessed in 22 patients at a standard planning scan (SCT) and individualized dietary advice was prescribed to regularize bowel habit. Patients were requested to record frequency and type of bowel movements, fibre and fluid intake daily. Two subsequent CT scans were acquired at 7 (CCT1) and 10days (CCT2) after SCT at a similar time. Rectal volume and gas were measured planning CT's and 'on treatment' cone beam CT scans. We hypothesised that the difference in volume between CCT1 and CCT2 would be less than the difference between SCT and CCT1. RESULTS: The mean (SD) change in volume between SCT to CCT1 and CCT1 to CCT2 was 5.68cm(3) (26.2) and -8.6cm(3) (40.1), respectively (p=0.292). Of the 22 patients scanned 20 provided a complete record of dietary intake and bowel motion. The majority of patients either achieved or exceeded prescription. Change in rectal gas was the only correlation with change in rectal volume. CONCLUSION: Patient self reporting of bowel motion, fibre, fluid intake was achievable but consistency of rectal filling was not improved. Improved understanding of the aetiology and management of rectal gas is indicated..
Brock, J.
McNair, H.A.
Panakis, N.
Symonds-Tayler, R.
Evans, P.M.
Brada, M.
(2011). The Use of the Active Breathing Coordinator Throughout Radical Non–Small-Cell Lung Cancer (NSCLC) Radiotherapy. International journal of radiation oncology*biology*physics,
Vol.81
(2),
pp. 369-375.
Chong, I.
Hawkins, M.
Hansen, V.
Thomas, K.
McNair, H.
O’Neill, B.
Aitken, A.
Tait, D.
(2011). Quantification of Organ Motion During Chemoradiotherapy of Rectal Cancer Using Cone-Beam Computed Tomography. International journal of radiation oncology*biology*physics,
Vol.81
(4),
pp. e431-e438.
Hawkins, M.A.
Aitken, A.
Hansen, V.N.
McNair, H.A.
Tait, D.M.
(2011). Cone beam CT verification for oesophageal cancer – impact of volume selected for image registration. Acta oncologica,
Vol.50
(8),
pp. 1183-1190.
Korreman, S.
Rasch, C.
McNair, H.
Verellen, D.
Oelfke, U.
Maingon, P.
Mijnheer, B.
Khoo, V.
(2010). The European Society of Therapeutic Radiology and Oncology–European Institute of Radiotherapy (ESTRO–EIR) report on 3D CT-based in-room image guidance systems: A practical and technical review and guide. Radiotherapy and oncology,
Vol.94
(2),
pp. 129-144.
Guerrero Urbano, T.
Khoo, V.
Staffurth, J.
Norman, A.
Buffa, F.
Jackson, A.
Adams, E.
Hansen, V.
Clark, C.
Miles, E.
McNair, H.
Nutting, C.
Parker, C.
Eeles, R.
Huddart, R.
Horwich, A.
Dearnaley, D.P.
(2010). Intensity-modulated radiotherapy allows escalation of the radiation dose to the pelvic lymph nodes in patients with locally advanced prostate cancer: preliminary results of a phase I dose escalation study. Clin oncol (r coll radiol),
Vol.22
(3),
pp. 236-244.
show abstract
Pelvic irradiation in addition to prostate irradiation may improve outcome in locally advanced prostate cancer, but is associated with dose-limiting bowel toxicity. We report the preliminary results of a dose escalation study using intensity-modulated radiotherapy..
Bhide, S.A.
Davies, M.
Burke, K.
McNair, H.A.
Hansen, V.
Barbachano, Y.
El-Hariry, I.A.
Newbold, K.
Harrington, K.J.
Nutting, C.M.
(2010). Weekly Volume and Dosimetric Changes During Chemoradiotherapy With Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Observational Study. International journal of radiation oncology*biology*physics,
Vol.76
(5),
pp. 1360-1368.
Lalondrelle, S.
McNair, H.
Hansen, V.
Huddart, R.
Dearnaley, D.
Khoo, V.
(2009). The Clinical Implementation of Cone Beam CT (CBCT) Technology through Adaptive Radiotherapy Planning (ART). Clin oncol-uk,
Vol.21
(1),
pp. 67-67.
Lalondrelle, S.
Taylor, H.
McNair, H.
Hansen, V.N.
Huddart, R.
Khoo, V.
(2009). Steps to Clinical Implementation of Online Image Guided Adaptive Radiotherapy. Clinical oncology,
Vol.21
(3),
pp. 256-256.
Partridge, M.
Tree, A.
Brock, J.
McNair, H.
Fernandez, E.
Panakis, N.
Brada, M.
(2009). Improvement in tumour control probability with active breathing control and dose escalation: A modelling study. Radiotherapy and oncology,
Vol.91
(3),
pp. 325-329.
McNair, H.A.
Brock, J.
Symonds-Tayler, J.R.
Ashley, S.
Eagle, S.
Evans, P.M.
Kavanagh, A.
Panakis, N.
Brada, M.
(2009). Feasibility of the use of the Active Breathing Co ordinator™ (ABC) in patients receiving radical radiotherapy for non-small cell lung cancer (NSCLC). Radiotherapy and oncology,
Vol.93
(3),
pp. 424-429.
McNair, H.A.
Hansen, V.N.
Parker, C.C.
Evans, P.M.
Norman, A.
Miles, E.
Harris, E.J.
Del-Acroix, L.
Smith, E.
Keane, R.
Khoo, V.S.
Thompson, A.C.
Dearnaley, D.P.
(2008). A comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of the potential benefit of online and offline verification protocols for prostate radiotherapy. Int j radiat oncol biol phys,
Vol.71
(1),
pp. 41-50.
show abstract
To evaluate the utility of intraprostatic markers in the treatment verification of prostate cancer radiotherapy. Specific aims were: to compare the effectiveness of offline correction protocols, either using gold markers or bony anatomy; to estimate the potential benefit of online correction protocol's using gold markers; to determine the presence and effect of intrafraction motion..
Bedford, J.L.
Nordmark Hansen, V.
McNair, H.A.
Aitken, A.H.
Brock, J.E.
Warrington, A.P.
Brada, M.
(2008). Treatment of lung cancer using volumetric modulated arc therapy and image guidance: A case study. Acta oncologica,
Vol.47
(7),
pp. 1438-1443.
Panakis, N.
McNair, H.A.
Christian, J.A.
Mendes, R.
Symonds-Tayler, J.R.
Knowles, C.
Evans, P.M.
Bedford, J.
Brada, M.
(2008). Defining the margins in the radical radiotherapy of non-small cell lung cancer (NSCLC) with active breathing control (ABC) and the effect on physical lung parameters. Radiotherapy and oncology,
Vol.87
(1),
pp. 65-73.
Mangar, S.A.
Miller, N.R.
Khoo, V.S.
Hansen, V.
McNair, H.
Horwich, A.
Huddart, R.A.
(2008). Evaluating Inter-fractional Changes in Volume and Position during Bladder Radiotherapy and the Effect of Volume Limitation as a Method of Reducing the Internal Margin of the Planning Target Volume. Clinical oncology,
Vol.20
(9),
pp. 698-704.
Mangar, S.A.
Miller, N.A.
Norman, A.
Hansen, V.
Foo, K.
McNair, H.
Horwich, A.
Huddart, R.A.
(2007). Evaluating the Impact of Volume Limitation as a Method of Reducing the Internal Margin of the PTV in Bladder Radiotherapy. Clinical oncology,
Vol.19
(3),
pp. S38-S39.
McNair, H.A.
Panakis, N.
Evans, P.
Brock, J.
Knowles, C.
Symonds-Tayler, J.R.
Brada, M.
(2007). Active Breathing Control (ABC) in Radical Radiotherapy of Non-small Cell Lung Cancer (NSCLC). Clinical oncology,
Vol.19
(3),
pp. S39-S39.
(2007). Gap analysis of role definition and training needs for therapeutic research radiographers in the UK. The british journal of radiology,
Vol.80
(957),
pp. 693-701.
Guerrero Urbano, T.
Clark, C.H.
Hansen, V.N.
Adams, E.J.
A'Hern, R.
Miles, E.A.
McNair, H.
Bidmead, M.
Warrington, A.P.
Dearnaley, D.P.
Harrington, K.J.
Nutting, C.M.
(2007). A phase I study of dose-escalated chemoradiation with accelerated intensity modulated radiotherapy in locally advanced head and neck cancer. Radiother oncol,
Vol.85
(1),
pp. 36-41.
show abstract
Intensity modulated radiotherapy (IMRT) allows the delivery of higher and more homogeneous radiation dose to head and neck tumours. This study aims to determine the safety of dose-escalated chemo-IMRT for larynx preservation in locally advanced head and neck cancer..
McNair, H.A.
Mangar, S.A.
Coffey, J.
Shoulders, B.
Hansen, V.N.
Norman, A.
Staffurth, J.
Sohaib, S.A.
Warrington, A.P.
Dearnaley, D.P.
(2006). A comparison of CT- and ultrasound-based imaging to localize the prostate for external beam radiotherapy. Int j radiat oncol biol phys,
Vol.65
(3),
pp. 678-687.
show abstract
This study assesses the accuracy of NOMOS B-mode acquisition and targeting system (BAT) compared with computed tomography (CT) in localizing the prostate..
O'Doherty, U.M.
McNair, H.A.
Norman, A.R.
Miles, E.
Hooper, S.
Davies, M.
Lincoln, N.
Balyckyi, J.
Childs, P.
Dearnaley, D.P.
Huddart, R.A.
(2006). Variability of bladder filling in patients receiving radical radiotherapy to the prostate. Radiother oncol,
Vol.79
(3),
pp. 335-340.
show abstract
Patients receiving radical radiotherapy to the prostate are requested to maintain a full bladder to displace the dome of the bladder and small bowel from the target volume. This study investigated patients' ability to consistently maintain a full bladder throughout planning and treatment before (Study 1) and after (Study 2) the introduction of a patient information sheet..
Harris, E.J.
McNair, H.A.
Evans, P.M.
(2006). Feasibility of fully automated detection of fiducial markers implanted into the prostate using electronic portal imaging: A comparison of methods. International journal of radiation oncology*biology*physics,
Vol.66
(4),
pp. 1263-1270.
Flampouri, S.
McNair, H.A.
Donovan, E.M.
Evans, P.M.
Partridge, M.
Verhaegen, F.
Nutting, C.M.
(2005). Initial patient imaging with an optimised radiotherapy beam for portal imaging. Radiotherapy and oncology,
Vol.76
(1),
pp. 63-71.
(2005). 997 ORAL Results of intensity modulated radiotherapy (IMRT) in laryngeal and hypopharyngeal cancer: A dose escalation study. European journal of cancer supplements,
Vol.3
(2),
pp. 287-287.
Christian, J.A.
Partridge, M.
Nioutsikou, E.
Cook, G.
McNair, H.A.
Cronin, B.
Courbon, F.
Bedford, J.L.
Brada, M.
(2005). The incorporation of SPECT functional lung imaging into inverse radiotherapy planning for non-small cell lung cancer. Radiotherapy and oncology,
Vol.77
(3),
pp. 271-277.
O'Sullivan, J.M.
Norman, A.R.
McNair, H.
Dearnaley, D.P.
(2004). Cranial nerve palsies in metastatic prostate cancer--results of base of skull radiotherapy. Radiother oncol,
Vol.70
(1),
pp. 87-90.
show abstract
We studied the rate of response to palliative external beam radiation therapy (20 Gy/5 or 30 Gy/10 fractions) to the base of skull in 32 prostate cancer patients with cranial nerve dysfunction. Sixteen patients (50%; 95% CI, 34-66%) had a useful response to therapy. The median survival post-therapy was 3 months..
Adams, E.J.
Convery, D.J.
Cosgrove, V.P.
McNair, H.A.
Staffurth, J.N.
Vaarkamp, J.
Nutting, C.M.
Warrington, A.P.
Webb, S.
Balyckyi, J.
Dearnaley, D.P.
(2004). Clinical implementation of dynamic and step-and-shoot IMRT to treat prostate cancer with high risk of pelvic lymph node involvement. Radiother oncol,
Vol.70
(1),
pp. 1-10.
show abstract
Two systems have been developed for treating patients with locally advanced prostate cancer using intensity-modulated radiotherapy (IMRT): one using dynamic multi-leaf collimator delivery and the other using step-and-shoot. This paper describes the clinical implementation of these two techniques, and presents results from the first 14 patients treated in a clinical setting (nine dynamic, five step-and-shoot)..
McNair, H.A.
Parker, C.
Hansen, V.N.
Askew, L.
Mukherjee, R.
Nutting, C.
Norman, A.R.
Dearnaley, D.P.
(2004). An evaluation of Beam cath in the verification process for prostate cancer radiotherapy. Clin oncol (r coll radiol),
Vol.16
(2),
pp. 138-147.
show abstract
As the trend towards more conformal treatment continues, the accuracy of treatment delivery becomes more important. Conventionally, treatment set-up for prostate cancer patients is verified in relation to the bony anatomy. However, there can be prostate movement independent of bony anatomy. This study tested the feasibility of using Beam cath to enable online correction of treatment set-up in relation to the prostate position, and to assess inter-fraction and intra-fraction prostate movement..
McNair, H.A.
Francis, G.
Balyckyi, J.
(2004). Clinical implementation of dynamic intensity-modulated radiotherapy: radiographers' perspectives. The british journal of radiology,
Vol.77
(918),
pp. 493-498.
Lee, Y.
(2003). Radiotherapy treatment planning of prostate cancer using magnetic resonance imaging alone. Radiotherapy and oncology,
Vol.66
(2),
pp. 203-216.
McNair, H.A.
Selous-Hodges, J.
Convery, D.
Cosgrove, V.
Balyckyi, J.
Dearnaley, D.P.
Nuttings, C.
(2003). Clinical implementation of intensity modulated radiotherapy: initial experiences. Journal of radiotherapy in practice,
Vol.3
(2),
pp. 63-67.
show abstract
The development of intensity modulated radiotherapy (IMRT) has allowed the delivery of concave dose distributions. Planning studies have demonstrated the potential clinical benefit of IMRT in the treatment of the prostate and pelvic nodes in patients with advanced prostate cancer. As a consequence, IMRT was clinically implemented in the Royal Marsden NHS Trust in September 2000, using Elekta Sli series linear accelerators and NOMOS Corvus v3.0 planning system. As a relatively new treatment procedure in the United Kingdom, the clinical implementation involved developing appropriate quality assurance and verification procedures as well as training staff. This paper describes the practicalities of implementing IMRT into the routine workload of the radiotherapy department..
Bollet, M.A.
McNair, H.A.
Hansen, V.N.
Norman, A.
O'Doherty, U.
Taylor, H.
Rose, M.
Mukherjee, R.
Huddart, R.
(2003). Can digitally reconstructed radiographs (DRRS) replace simulation films in prostate cancer conformal radiotherapy?. International journal of radiation oncology*biology*physics,
Vol.57
(4),
pp. 1122-1130.
McNair, H.A.
Adams, E.J.
Clark, C.H.
Miles, E.A.
Nutting, C.M.
(2003). Implementation of IMRT in the radiotherapy department. The british journal of radiology,
Vol.76
(912),
pp. 850-856.
McNair, H.A.
Adams, E.J.
Clark, C.H.
Miles, E.A.
Nutting, C.M.
(2003). Implementation of IMRT in the radiotherapy department 10 1259/bjr/19737738. British journal of radiology,
Vol.76
(912),
pp. 850-856.
Nutting, C.M.
Khoo, V.S.
Walker, V.
McNair, H.
Beardmore, C.
Norman, A.
Dearnaley, D.P.
(2000). A randomized study of the use of a customized immobilization system in the treatment of prostate cancer with conformal radiotherapy. Radiother oncol,
Vol.54
(1),
pp. 1-9.
show abstract
To evaluate the impact of a customized immobilisation system on field placement accuracy, simulation and treatment delivery time, radiographer convenience and patient acceptability..
Jalali,
Brada,
Perks,
Warrington,
Traish,
Burchell,
McNair,
Thomas,
Robinson,
Johnston,
(2000). Stereotactic conformal radiotherapy for pituitary adenomas: technique and preliminary experience. Clinical endocrinology,
Vol.52
(6),
pp. 695-702.
Bartlett, F.R.
Colgan, R.M.
Donovan, E.M.
Carr, K.
Landeg, S.
Clements, N.
McNair, H.A.
Locke, I.
Evans, P.M.
Haviland, J.S.
Yarnold, J.R.
Kirby, A.M.
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy. Journal of visualized experiments,
(89).
Dearnaley, D.
Murray, J.
McNair, H.
Rationale and development of image-guided intensity-modulated radiotherapy post-prostatectomy: the present standard of care?. Cancer management and research,
,
pp. 331-331.
Wedlake, L.
Shaw, C.
McNair, H.
Lalji, A.
Mohammed, K.
Klopper, T.
Allan, L.
Tait, D.
Hawkins, M.
Somaiah, N.
Lalondrelle, S.
Taylor, A.
VanAs, N.
Stewart, A.
Essapen, S.
Gage, H.
Whelan, K.
Andreyev, H.J.
Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy. The american journal of clinical nutrition,
,
pp. ajcn150565-ajcn150565.
Dearnaley, D.
reis ferreira, M.
khan, A.
truelove, L.
gao, A.
parker, C.
huddart, R.
eeles, R.
khoo, V.
van as, N.
A phase I/II dose escalation study of the use of intensity modulated radiotherapy (IMRT) to treat the prostate and pelvic nodes in patients with prostate cancer. International journal of radiation oncology • biology • physics,
.
Gothard, L.
Edmunds, D.
Khabra, K.
Kirby, A.
Poonam, M.
McNair, H.
Roberts, D.
Symonds-Tayler, R.
Donovan, E.
Low-cost Kinect Version 2 imaging system for breath hold monitoring and gating: Proof of concept study for breast cancer VMAT radiotherapy. Journal of applied clinical medical physics,
.
Beasley, M.
Brown, S.
McNair, H.
Faivre-Finn, C.
Franks, K.
Murray, L.
van Herk, M.
Henry, A.
The advanced radiotherapy network (ART-NET) UK lung stereotactic ablative radiotherapy survey: national provision and a focus on image guidance. The british journal of radiology,
,
pp. 20180988-20180988.
Hall, E.
Huddart, R.
Hafeez, S.
Lewis, R.
McNair, H.
Dewan, M.
Khoo, V.
Clinical outcomes of a randomised trial of adaptive plan of the day treatment in patients receiving ultra-hypofractionated weekly radiotherapy for bladder cancer. International journal of radiation: oncology - biology - physics,
.
Edmunds, D.
Gothard, L.
Khabra, K.
Kirby, A.
Madhale, P.
McNair, H.
Roberts, D.
Symonds-Tayler, R.
Donovan, E.
Low-cost Kinect Version 2 imaging system for breath hold monitoring and gating: Proof of concept study for breast cancer VMAT radiotherapy. Journal of applied clinical medical physics,
.
Hall, E.
Hafeez, S.
McNair, H.
Lewis, R.
Huddart, R.
Protocol for hypofractionated adaptive radiotherapy to the bladder within a multi-centre phase II randomised trial: radiotherapy planning and delivery guidance. Bmj open,
.
Harris, E.
Tree, A.
McNair, H.
Grimwood, A.
Bamber, J.
hassan, R.
Hang, Z.
Improving 3D ultrasound prostate localisation in radiotherapy through increased automation of interfraction matching. Radiotherapy and oncology,
.