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Burns, M.C., Howes, J.E., Sun, Q., Little, A.J., Camper, D.V., Abbott, J.R., Phan, J., Lee, T., Waterson, A.G., Rossanese, O.W., et al. (2018). High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal biochem, Vol.548, pp. 44-52.  show abstract

Howes, J.E., Akan, D.T., Burns, M.C., Rossanese, O.W., Waterson, A.G. & Fesik, S.W. (2018). Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1. Mol cancer ther, Vol.17 (5), pp. 1051-1060.  show abstract

Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., et al. (2018). Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J med chem, Vol.61 (19), pp. 8875-8894.  show abstract

Abbott, J.R., Hodges, T.R., Daniels, R.N., Patel, P.A., Kennedy, J.P., Howes, J.E., Akan, D.T., Burns, M.C., Sai, J., Sobolik, T., et al. (2018). Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. J med chem, .  show abstract

Wang, F., Jeon, K.O., Salovich, J.M., Macdonald, J.D., Alvarado, J., Gogliotti, R.D., Phan, J., Olejniczak, E.T., Sun, Q., Wang, S., et al. (2018). Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J med chem, Vol.61 (13), pp. 5623-5642.  show abstract

Abbott, J.R., Patel, P.A., Howes, J.E., Akan, D.T., Kennedy, J.P., Burns, M.C., Browning, C.F., Sun, Q., Rossanese, O.W., Phan, J., et al. (2018). Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS. Acs med chem lett, Vol.9 (9), pp. 941-946.  show abstract

Shaw, S., Bian, Z., Zhao, B., Tarr, J.C., Veerasamy, N., Jeon, K.O., Belmar, J., Arnold, A.L., Fogarty, S.A., Perry, E., et al. (2018). Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design. J med chem, Vol.61 (6), pp. 2410-2421.  show abstract

Lee, T., Bian, Z., Zhao, B., Hogdal, L.J., Sensintaffar, J.L., Goodwin, C.M., Belmar, J., Shaw, S., Tarr, J.C., Veerasamy, N., et al. (2017). Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. Febs lett, Vol.591 (1), pp. 240-251.  show abstract

Hatch, S.B., Yapp, C., Montenegro, R.C., Savitsky, P., Gamble, V., Tumber, A., Ruda, G.F., Bavetsias, V., Fedorov, O., Atrash, B., et al. (2017). Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics chromatin, Vol.10, p. 9.  show abstract

Pelz, N.F., Bian, Z., Zhao, B., Shaw, S., Tarr, J.C., Belmar, J., Gregg, C., Camper, D.V., Goodwin, C.M., Arnold, A.L., et al. (2016). Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. J med chem, Vol.59 (5), pp. 2054-2066.  show abstract

Kanu, N., Cerone, M.A., Goh, G., Zalmas, L.-., Bartkova, J., Dietzen, M., McGranahan, N., Rogers, R., Law, E.K., Gromova, I., et al. (2016). DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. Genome biol, Vol.17 (1), p. 185.  show abstract

Patrone, J.D., Pelz, N.F., Bates, B.S., Souza-Fagundes, E.M., Vangamudi, B., Camper, D.V., Kuznetsov, A.G., Browning, C.F., Feldkamp, M.D., Frank, A.O., et al. (2016). Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A. Chemmedchem, Vol.11 (8), pp. 893-899.  show abstract

Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Feldkamp, M.D., Frank, A.O., Vangamudi, B., Souza-Fagundes, E.M., Rossanese, O.W., Chazin, W.J., et al. (2015). Diphenylpyrazoles as replication protein a inhibitors. Acs med chem lett, Vol.6 (2), pp. 140-145.  show abstract

Goodwin, C.M., Rossanese, O.W., Olejniczak, E.T. & Fesik, S.W. (2015). Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer. Cell death differ, Vol.22 (12), pp. 2098-2106.  show abstract

Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., et al. (2015). Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. J med chem, Vol.58 (9), pp. 3794-3805.  show abstract

Bhave, M., Papanikou, E., Iyer, P., Pandya, K., Jain, B.K., Ganguly, A., Sharma, C., Pawar, K., Austin, J., Day, K.J., et al. (2014). Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation. J cell sci, Vol.127 (Pt 1), pp. 250-257.  show abstract

Burns, M.C., Sun, Q., Daniels, R.N., Camper, D., Kennedy, J.P., Phan, J., Olejniczak, E.T., Lee, T., Waterson, A.G., Rossanese, O.W., et al. (2014). Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc natl acad sci u s a, Vol.111 (9), pp. 3401-3406.  show abstract

Frank, A.O., Vangamudi, B., Feldkamp, M.D., Souza-Fagundes, E.M., Luzwick, J.W., Cortez, D., Olejniczak, E.T., Waterson, A.G., Rossanese, O.W., Chazin, W.J., et al. (2014). Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J med chem, Vol.57 (6), pp. 2455-2461.  show abstract

Patrone, J.D., Kennedy, J.P., Frank, A.O., Feldkamp, M.D., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Chazin, W.J. & Fesik, S.W., et al. (2013). Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. Acs med chem lett, Vol.4 (7), pp. 601-605.  show abstract

Rheault, T.R., Stellwagen, J.C., Adjabeng, G.M., Hornberger, K.R., Petrov, K.G., Waterson, A.G., Dickerson, S.H., Mook, R.A., Laquerre, S.G., King, A.J., et al. (2013). Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors. Acs med chem lett, Vol.4 (3), pp. 358-362.  show abstract

Frank, A.O., Feldkamp, M.D., Kennedy, J.P., Waterson, A.G., Pelz, N.F., Patrone, J.D., Vangamudi, B., Camper, D.V., Rossanese, O.W., Chazin, W.J., et al. (2013). Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J med chem, Vol.56 (22), pp. 9242-9250.  show abstract

Souza-Fagundes, E.M., Frank, A.O., Feldkamp, M.D., Dorset, D.C., Chazin, W.J., Rossanese, O.W., Olejniczak, E.T. & Fesik, S.W. (2012). A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A. Anal biochem, Vol.421 (2), pp. 742-749.  show abstract

Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W. & Fesik, S.W. (2012). Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew chem int ed engl, Vol.51 (25), pp. 6140-6143.

Stellwagen, J.C., Adjabeng, G.M., Arnone, M.R., Dickerson, S.H., Han, C., Hornberger, K.R., King, A.J., Mook, R.A., Petrov, K.G., Rheault, T.R., et al. (2011). Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg med chem lett, Vol.21 (15), pp. 4436-4440.  show abstract

Losev, E., Papanikou, E., Rossanese, O.W. & Glick, B.S. (2008). Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Mol cell biol, Vol.28 (10), pp. 3336-3343.  show abstract

Patel, J.C., Rossanese, O.W. & Galán, J.E. (2005). The functional interface between Salmonella and its host cell: opportunities for therapeutic intervention. Trends pharmacol sci, Vol.26 (11), pp. 564-570.  show abstract

Jiang, X., Rossanese, O.W., Brown, N.F., Kujat-Choy, S., Galán, J.E., Finlay, B.B. & Brumell, J.H. (2004). The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice. Mol microbiol, Vol.54 (5), pp. 1186-1198.  show abstract

Rossanese, O.W., Reinke, C.A., Bevis, B.J., Hammond, A.T., Sears, I.B., O'Connor, J. & Glick, B.S. (2001). A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J cell biol, Vol.153 (1), pp. 47-62.  show abstract

Rossanese, O.W. & Glick, B.S. (2001). Deconstructing Golgi inheritance. Traffic, Vol.2 (9), pp. 589-596.  show abstract

Rossanese, O.W., Soderholm, J., Bevis, B.J., Sears, I.B., O'Connor, J., Williamson, E.K. & Glick, B.S. (1999). Golgi structure correlates with transitional endoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae. J cell biol, Vol.145 (1), pp. 69-81.  show abstract

Séron, K., Tieaho, V., Prescianotto-Baschong, C., Aust, T., Blondel, M.O., Guillaud, P., Devilliers, G., Rossanese, O.W., Glick, B.S., Riezman, H., et al. (1998). A yeast t-SNARE involved in endocytosis. Mol biol cell, Vol.9 (10), pp. 2873-2889.  show abstract

Sears, I.B., O'Connor, J., Rossanese, O.W. & Glick, B.S. (1998). A versatile set of vectors for constitutive and regulated gene expression in Pichia pastoris. Yeast, Vol.14 (8), pp. 783-790.  show abstract


Conferences

Lee, T., Tarr, J., Zhao, B., Bian, Z., Shaw, S., Belmar, J., Arnold, A., Sensintaffar, J., Moore, W., Stott, G., et al. (2018). Discovery of novel tricyclic Mcl-1 inhibitors that exhibit selective anti-proliferative activity and in vivo efficacy, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.256.

Waterson, A.G., Kennedy, P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Camper, D.V., Souza-Fagundes, E.M., Feldkamp, M.D., Olejniczak, E.T., et al. (2015). Discovery of probes to evaluate the disruption of the protein-protein interactions mediated by RPA70N, CANCER RESEARCH, Vol.75.

Rossanese, O.W., Burns, M.C., Sun, Q., Daniels, R.N., Camper, D.V., Kennedy, J.P., Phan, J., Olejniczak, E.T., Lee, T., Waterson, A.G., et al. (2014). Targeting Ras with small molecules that activate SOS-mediated nucleotide exchange, CANCER RESEARCH, Vol.74 (19).

Waterson, A.G., Frank, A.O., Vandgamudi, B., Feldkamp, M.D., Souza-Fagundes, E.M., Luzwick, J.W., Cortez, D., Olejniczak, E.T., Rossanese, O.W., Chazin, W.J., et al. (2014). Optimization of a potent stapled helix peptide that binds to Replication Protein A, CANCER RESEARCH, Vol.74 (19).

Burns, M., Sun, Q., Daniels, R., Kennedy, J.P., Camper, D., Phan, J., Olejniczak, E., Lee, T., Waterson, A., Rossanese, O., et al. (2013). Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange, MOLECULAR CANCER THERAPEUTICS, Vol.12 (11).

Vangamudi, B., Frank, A.O., Souza-Fagundes, E.M., Feldkamp, M.D., Olejniczak, E.T., Rossanese, O.W. & Fesik, S.W. (2013). Stapled helix peptides as probes to evaluate targeted disruption of protein-protein interactions mediated by RPA70N., CANCER RESEARCH, Vol.73 (8).

Vangamudi, B., Ayres, A.E., Burke, J.P., Waterson, A.G., Rossanese, O.W. & Fesik, S.W. (2012). Evaluation of TBK1 as a novel cancer target in the K -Ras pathway, CANCER RESEARCH, Vol.72.

Losev, E., Rossanese, O.W. & Glick, B.S. (2002). The predicted phosphoesterase Cdc1p is important for late Golgi inheritance, MOLECULAR BIOLOGY OF THE CELL, Vol.13, p.269A.

Reinke, C.A., Rossanese, O.W., Bevis, B.J. & Glick, B.S. (2002). Golgi inheritance in Saccharomyces cerevisiae is compromised in an ER inheritance mutant, MOLECULAR BIOLOGY OF THE CELL, Vol.13, p.269A.

Reinke, C.A., Rossanese, O.W., Bevis, B.J. & Glick, B.S. (2000). Genetic analysis of Golgi morphology and inheritance in Saccharomyces cerevisiae., MOLECULAR BIOLOGY OF THE CELL, Vol.11, pp.281A-282A.

Rossanese, O.W., Soderholm, J., Sears, I.B., Connor, J.O., Williamson, E.K. & Glick, B.S. (1998). Golgi structure correlates with transitional ER organization in budding yeasts., MOLECULAR BIOLOGY OF THE CELL, Vol.9, p.222A.

Rossanese, O.W. & Glick, B.S. (1998). Genetic analysis of Golgi inheritance in Saccharomyces cerevisiae., MOLECULAR BIOLOGY OF THE CELL, Vol.9, p.223A.

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