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Journal Articles

von Loga, K. Woolston, A. Punta, M. Barber, L. Griffiths, B. Semiannikova, M. Spain, G. Challoner, B. Fenwick, K. Simon, R. Marx, A. Sauter, G. Lise, S. Matthews, N. Gerlinger, M. (2020). Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer. Nature communications, Vol.11 (1), pp. 139-139.  show abstract

Challoner, B.R. von Loga, K. Woolston, A. Griffiths, B. Sivamanoharan, N. Semiannikova, M. Newey, A. Barber, L.J. Mansfield, D. Hewitt, L.C. Saito, Y. Davarzani, N. Starling, N. Melcher, A. Grabsch, H.I. Gerlinger, M. (2020). Computational image analysis of T-cell infiltrates in resectable gastric cancer: association with survival and molecular subtypes. J natl cancer inst, .  show abstract

Woolston, A. Khan, K. Spain, G. Barber, L.J. Griffiths, B. Gonzalez-Exposito, R. Hornsteiner, L. Punta, M. Patil, Y. Newey, A. Mansukhani, S. Davies, M.N. Furness, A. Sclafani, F. Peckitt, C. Jiménez, M. Kouvelakis, K. Ranftl, R. Begum, R. Rana, I. Thomas, J. Bryant, A. Quezada, S. Wotherspoon, A. Khan, N. Fotiadis, N. Marafioti, T. Powles, T. Lise, S. Calvo, F. Guettler, S. von Loga, K. Rao, S. Watkins, D. Starling, N. Chau, I. Sadanandam, A. Cunningham, D. Gerlinger, M. (2019). Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Cancer cell, Vol.36 (1), pp. 35-50.e9.  show abstract

Lipinski, K.A. Barber, L.J. Davies, M.N. Ashenden, M. Sottoriva, A. Gerlinger, M. (2016). Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine. Trends cancer, Vol.2 (1), pp. 49-63.  show abstract

Gerlinger, M. Horswell, S. Larkin, J. Rowan, A.J. Salm, M.P. Varela, I. Fisher, R. McGranahan, N. Matthews, N. Santos, C.R. Martinez, P. Phillimore, B. Begum, S. Rabinowitz, A. Spencer-Dene, B. Gulati, S. Bates, P.A. Stamp, G. Pickering, L. Gore, M. Nicol, D.L. Hazell, S. Futreal, P.A. Stewart, A. Swanton, C. (2014). Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat genet, Vol.46 (3), pp. 225-233.  show abstract

Gerlinger, M. Rowan, A.J. Horswell, S. Larkin, J. Endesfelder, D. Gronroos, E. Martinez, P. Matthews, N. Stewart, A. Tarpey, P. Varela, I. Phillimore, B. Begum, S. McDonald, N.Q. Butler, A. Jones, D. Raine, K. Latimer, C. Santos, C.R. Nohadani, M. Eklund, A.C. Spencer-Dene, B. Clark, G. Pickering, L. Stamp, G. Gore, M. Szallasi, Z. Downward, J. Futreal, P.A. Swanton, C. (2012). Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. New england journal of medicine, Vol.366 (10), pp. 883-892.

Gonzalez-Exposito, R. Semiannikova, M. Griffiths, B. Khan, K. Barber, L. Woolston, A. Spain, G. von Loga, K. Challoner, B. Patel, R. Ranes, M. Swain, A. Thomas, J. Bryant, A. Saffery, C. Fotiadis, N. Guettler, S. Mansfield, D. Melcher, A. Powles, T. Rao, S. Watkins, D. Chau, I. Matthews, N. Wallberg, F. Starling, N. Cunningham, D. Gerlinger, M. CEA Expression Heterogeneity and Plasticity Confer Resistance to the CEA-Targeting Bispecific Immunotherapy Antibody Cibisatamab (CEA-TCB) in Patient-Derived Colorectal Cancer Organoids. Journal for immunotherapy of cancer, .  show abstract

Davidson, M. Barber, L.J. Woolston, A. Cafferkey, C. Mansukhani, S. Griffiths, B. Moorcraft, S.-. Rana, I. Begum, R. Assiotis, I. Matthews, N. Rao, S. Watkins, D. Chau, I. Cunningham, D. Starling, N. Gerlinger, M. Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma. Cancers, Vol.11 (5), pp. 736-736.  show abstract

Newey, A. Griffiths, B. Michaux, J. Pak, H. Stevenson, B. Woolston, A. Semiannikova, M. Spain, G. Barber, L. Matthews, N. Rao, S. Watkins, D. Chau, I. Coukos, G. Racle, J. Gfeller, D. Starling, N. Cunningham, D. Bassani-Sternberg, M. Gerlinger, M. Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment. Journal for immunotherapy of cancer, .

Barber, L. Mansukhani, S. Kleftogiannis, D. Moorcraft, S.Y. Davidson, M. Woolston, A. Proszek, P. Griffiths, B. Fenwick, K. Matthews, N. O'Leary, B. Hulkki, S. Gonzalez de Castro, D. Wotherspoon, A. Okachi, A. Rana, I. Begum, R. Davies, M. von Loga, K. Hubank, M. Turner, N. Watkins, D. Chau, I. Cunningham, D. Lise, S. Starling, N. Gerlinger, M. Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumor DNA sequencing. Clinical chemistry, .


Conferences

Davidson, M.Mansukhani, S.Starling, N.Chau, I.Watkins, D.Cunningham, D.Rao, S.Lazaro-Alcausi, R.Griffiths, B.Barber, L.Morganstein, D.Forster, M.D.Davies, S.Begum, R.Gillbanks, A.Kalaitzaki, E.Wotherspoon, A.Von Loga, K.Chaudry, A.Gerlinger, M. (2019). Perioperative FLOT + anti-PD-L1 avelumab (FLOT-A) chemo-immunotherapy in resectable oesophagogastric adenocarcinoma (OGA): Safety and biomarker data from the ICONIC trial safety run-in, ANNALS OF ONCOLOGY, Vol.30.

Turkes, F.S.Crux, R.Cunningham, D.Athauda, A.Kalaitzaki, E.Musallam, A.Begum, R.De Paepe, K.Fotiadis, N.Riddell, A.Von Loga, K.Kinross, J.Marchesi, J.R.Teare, J.Morganstein, D.Rao, S.Watkins, D.Chau, I.Gerlinger, M.Starling, N. (2019). iSCORE: Immunotherapy sequencing in colon and rectal cancer, ANNALS OF ONCOLOGY, Vol.30.