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Journal Articles

Te Lintel Hekkert, M. Newton, G. Chapman, K. Aqil, R. Downham, R. Yan, R. Merkus, D. Whitlock, G. Lane, C.A. Cawkill, D. Perrior, T. Duncker, D.J. Schneider, M.D. (2021). Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?. Basic research in cardiology, Vol.116 (1), pp. 34-?.  show abstract

Golforoush, P.A. Narasimhan, P. Chaves-Guerrero, P.P. Lawrence, E. Newton, G. Yan, R. Harding, S.E. Perrior, T. Chapman, K.L. Schneider, M.D. (2020). Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4. Scientific reports, Vol.10 (1), pp. 12060-?.  show abstract

Fiedler, L.R. Chapman, K. Xie, M. Maifoshie, E. Jenkins, M. Golforoush, P.A. Bellahcene, M. Noseda, M. Faust, D. Jarvis, A. Newton, G. Paiva, M.A. Harada, M. Stuckey, D.J. Song, W. Habib, J. Narasimhan, P. Aqil, R. Sanmugalingam, D. Yan, R. Pavanello, L. Sano, M. Wang, S.C. Sampson, R.D. Kanayaganam, S. Taffet, G.E. Michael, L.H. Entman, M.L. Tan, T.-. Harding, S.E. Low, C.M. Tralau-Stewart, C. Perrior, T. Schneider, M.D. (2019). MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell stem cell, Vol.24 (4), pp. 579-591.e12.  show abstract

Zhang, J. Chen, J. Newton, G.K. Perrior, T.R. Robinson, C. (2018). Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design. Molecular pharmacology, Vol.94 (3), pp. 1007-1030.  show abstract

Zhang, J. Chen, J. Zuo, J. Newton, G.K. Stewart, M.R. Perrior, T.R. Garrod, D.R. Robinson, C. (2018). Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens. International journal of molecular sciences, Vol.19 (10).  show abstract

Newton, G.K. Perrior, T.R. Jenkins, K. Major, M.R. Key, R.E. Stewart, M.R. Firth-Clark, S. Lloyd, S.M. Zhang, J. Francis-Newton, N.J. Richardson, J.P. Chen, J. Lai, P. Garrod, D.R. Robinson, C. (2014). The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma. Journal of medicinal chemistry, Vol.57 (22), pp. 9447-9462.

Robinson, C. Zhang, J. Newton, G.K. Perrior, T.R. (2013). Nonhuman targets in allergic lung conditions. Future medicinal chemistry, Vol.5 (2), pp. 147-161.  show abstract

Robinson, C. Zhang, J. Garrod, D.R. Newton, G.K. Jenkins, K. Perrior, T.R. (2011). Future inhaled drugs by virtual innovation: allergen delivery inhibitors. Future medicinal chemistry, Vol.3 (13), pp. 1567-1570.

Aggarwal, V.K. Grainger, R.S. Newton, G.K. Spargo, P.L. Hobson, A.D. Adams, H. (2003). Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton. Organic & biomolecular chemistry, Vol.1 (11), pp. 1884-1884.

Wilding, B. Pasqua, A.E. E A Chessum, N. Pierrat, O.A. Hahner, T. Tomlin, K. Shehu, E. Burke, R. Richards, G.M. Whitton, B. Arwert, E.N. Thapaliya, A. Salimraj, R. van Montfort, R. Skawinska, A. Hayes, A. Raynaud, F. Chopra, R. Jones, K. Newton, G. Cheeseman, M.D. Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1. Bioorganic & medicinal chemistry letters, Vol.42, pp. 128050-?.  show abstract


Patents and patent applications

Newton, G.Schneider, M. MAP4K4 Inhibitors.GB2018052936W.

Newton, G.Schneider, M. MAP4K4 Inhibitors.GB2019053429W.

Newton, G. 5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS.GB2018050475W.

Newton, G.Stewart, M. PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS.GB2014050521W.

Newton, G.Lord, C. COMPOUNDS AND THEIR USES.GB2012051978W.

Newton, G.Stewart, M. PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.GB2011001075W.

Newton, G.Robinson, C.Jenkins, K. ALDEHYDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE.GB2011001011W.

Newton, G.Robinson, C.Jenkins, K. PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE.GB2011000079W.

Newton, G.Wynne, G.Keily, J.Smyth, D.Crew, A. (2-carboxamido)(3-amino)thiophene compounds.https://worldwide.espacenet.com/.

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