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Journal Articles

Graham, T.A. & Sottoriva, A. (2017). Measuring cancer evolution from the genome. The journal of pathology, Vol.241(2), pp. 183-191.  show abstract

Sottoriva, A., Barnes, C.P. & Graham, T.A. (2017). Catch my drift? Making sense of genomic intra-tumour heterogeneity. Biochimica et biophysica acta (bba) - reviews on cancer, Vol.1867(2), pp. 95-100.  show abstract

Sun, R., Hu, Z., Sottoriva, A., Graham, T.A., Harpak, A., Ma, Z., Fisher, J.M., Shibata, D. & Curtis, C. (2017). Between-Region Genetic Divergence Reflects the Mode and Tempo of Tumor Evolution. Nature genetics, Vol.49(7), pp. 1015-1024.  show abstract

Lote, H., Spiteri Sagastume, I., Ermini, L., Vatsiou, A., Roy, A., McDonald, A., Maka, N., Balsitis, M., Bose, N., Simbolo, M., et al. (2017). Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. Annals of oncology, Vol.28(6), pp. 1243-1249.  show abstract

Maley, C.C., Aktipis, A., Graham, T.A., Sottoriva, A., Boddy, A.M., Janiszewska, M., Silva, A.S., Gerlinger, M., Yuan, Y., Pienta, K.J., et al. (2017). Classifying the evolutionary and ecological features of neoplasms. Nature reviews cancer, Vol.17(10), pp. 605-619.  show abstract

Werner, B., Traulsen, A., Sottoriva, A. & Dingli, D. (2017). Detecting truly clonal alterations from multi-region profiling of tumours. Scientific reports, Vol.7, pp. 44991-44991.  show abstract

Williams, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. (2017). Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nature genetics, Vol.49(9), pp. 1289-1291.

Werner, B., Scott, J.G., Sottoriva, A., Anderson, A.R., Traulsen, A. & Altrock, P.M. (2016). The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer research, Vol.76(7), pp. 1705-1713.  show abstract

Williams, M.J., Werner, B., Graham, T.A. & Sottoriva, A. (2016). Functional versus non-functional intratumor heterogeneity in cancer. Molecular & cellular oncology, Vol.3(4), pp. e1162897-e1162897.  show abstract

Eskilsson, E., Rosland, G.V., Talasila, K.M., Knappskog, S., Keunen, O., Sottoriva, A., Foerster, S., Solecki, G., Taxt, T., Jirik, R., et al. (2016). EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. Neuro-oncology, Vol.18(12), pp. 1644-1655.  show abstract

Williams, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. (2016). Identification of neutral tumor evolution across cancer types. Nature genetics, Vol.48(3), pp. 238-244.  show abstract  full text

Lipinski, K.A., Barber, L.J., Davies, M.N., Ashenden, M., Sottoriva, A. & Gerlinger, M. (2016). Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine. Trends in cancer, Vol.2(1), pp. 49-63.  show abstract  full text

Piccirillo, S.G., Spiteri, I., Sottoriva, A., Touloumis, A., Ber, S., Price, S.J., Heywood, R., Francis, N.-., Howarth, K.D., Collins, V.P., et al. (2015). Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal Zone. Cancer research, Vol.75(1), pp. 194-202.  show abstract

Gubernator, M., Slater, S.C., Spencer, H.L., Spiteri, I., Sottoriva, A., Riu, F., Rowlinson, J., Avolio, E., Katare, R., Mangialardi, G., et al. (2015). Epigenetic Profile of Human Adventitial Progenitor Cells Correlates With Therapeutic Outcomes in a Mouse Model of Limb IschemiaSignificance. Arteriosclerosis, thrombosis, and vascular biology, Vol.35(3), pp. 675-688.  show abstract

Sottoriva, A., Kang, H., Ma, Z., Graham, T.A., Salomon, M.P., Zhao, J., Marjoram, P., Siegmund, K., Press, M.F., Shibata, D., et al. (2015). A Big Bang model of human colorectal tumor growth. Nature genetics, Vol.47(3), pp. 209-216.  show abstract  full text

Kang, H., Salomon, M.P., Sottoriva, A., Zhao, J., Toy, M., Press, M.F., Curtis, C., Marjoram, P., Siegmund, K. & Shibata, D., et al. (2015). Many private mutations originate from the first few divisions of a human colorectal adenoma. The journal of pathology, Vol.237(3), pp. 355-362.  show abstract

Ellis, H.P., Greenslade, M., Powell, B., Spiteri, I., Sottoriva, A. & Kurian, K.M. (2015). Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence. Frontiers in oncology, Vol.5, p. 251.  show abstract  full text

Piccirillo, S.G., Sottoriva, A. & Watts, C. (2015). The role of sub-ventricular zone in gliomagenesis. Aging, Vol.7(10), pp. 738-739.  full text

Sottoriva, A., Spiteri, I., Shibata, D., Curtis, C. & Tavare, S. (2013). Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization. Cancer research, Vol.73(1), pp. 41-49.  show abstract

Dvinge, H., Git, A., Gräf, S., Salmon-Divon, M., Curtis, C., Sottoriva, A., Zhao, Y., Hirst, M., Armisen, J., Miska, E.A., et al. (2013). The shaping and functional consequences of the microRNA landscape in breast cancer. Nature, Vol.497(7449), pp. 378-382.  show abstract

Sottoriva, A., Spiteri, I., Piccirillo, S.G., Touloumis, A., Collins, V.P., Marioni, J.C., Curtis, C., Watts, C. & Tavare, S. (2013). Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proceedings of the national academy of sciences, Vol.110(10), pp. 4009-4014.  show abstract

Vermeulen, L., Morrissey, E., van der Heijden, M., Nicholson, A.M., Sottoriva, A., Buczacki, S., Kemp, R., Tavare, S. & Winton, D.J. (2013). Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation. Science, Vol.342(6161), pp. 995-998.  show abstract

Sottoriva, A., Vermeulen, L. & Tavaré, S. (2011). Modeling Evolutionary Dynamics of Epigenetic Mutations in Hierarchically Organized Tumors. Plos computational biology, Vol.7(5), pp. e1001132-e1001132.  show abstract  full text

Ageron, M., Aguilar, J., Al Samarai, I., Albert, A., Ameli, F., André, M., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., et al. (2011). ANTARES: The first undersea neutrino telescope. Nuclear instruments and methods in physics research section a: accelerators, spectrometers, detectors and associated equipment, Vol.656(1), pp. 11-38.  show abstract

Sottoriva, A., Verhoeff, J.J., Borovski, T., McWeeney, S.K., Naumov, L., Medema, J.P., Sloot, P.M. & Vermeulen, L. (2010). Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity. Cancer research, Vol.70(1), pp. 46-56.  show abstract

Sottoriva, A., Sloot, P.M., Medema, J.P. & Vermeulen, L. (2010). Exploring cancer stem cell niche directed tumor growth. Cell cycle, Vol.9(8), pp. 1472-1479.  show abstract

Sottoriva, A. & Tavare, S. (2010). Integrating Approximate Bayesian Computation with Complex Agent-Based Models for Cancer Research. Compstat'2010: 19th international conference on computational statistics, , pp. 57-66.

Portegies Zwart, S., McMillan, S., Harfst, S., Groen, D., Fujii, M., Nualláin, B.Ó., Glebbeek, E., Heggie, D., Lombardi, J., Hut, P., et al. (2009). A multiphysics and multiscale software environment for modeling astrophysical systems. New astronomy, Vol.14(4), pp. 369-378.  show abstract

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