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Journal Articles

Welti, J., Sharp, A., Yuan, W., Dolling, D., Nava Rodrigues, D., Figueiredo, I., Gil, V., Neeb, A., Clarke, M., Seed, G., et al. (2018). Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC). Clinical cancer research, Vol.24 (13), pp. 3149-3162.

Lord, C., Guettler, S., Lord, C. & Guettler, S. (2018). Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nature communications, Vol.9.  show abstract

Francis, J.C. & Swain, A. (2018). Prostate Organogenesis. Cold spring harbor perspectives in medicine, Vol.8 (7), pp. a030353-a030353.

Francis, J.C., Capper, A., Ning, J., Knight, E., de Bono, J. & Swain, A. (2018). SOX9 is a driver of aggressive prostate cancer by promoting invasion, cell fate and cytoskeleton alterations and epithelial to mesenchymal transition. Oncotarget, Vol.9 (7).

Shenoy, T.R., Boysen, G., Wang, M.Y., Xu, Q.Z., Guo, W., Koh, F.M., Wang, C., Zhang, L.Z., Wang, Y., Gil, V., et al. (2017). CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair. Annals of oncology, Vol.28 (7), pp. 1495-1507.

Ahmad, T., Bouwman, R.A., Grigoras, I., Aldecoa, C., Hofer, C., Hoeft, A., Holt, P., Fleisher, L.A., Buhre, W. & Pearse, R.M., et al. (2017). Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery. British journal of anaesthesia, Vol.119 (2), pp. 258-266.

Pettitt, S.J., Krastev, D.B., Pemberton, H.N., Fontebasso, Y., Frankum, J., Rehman, F.L., Brough, R., Song, F., Bajrami, I., Rafiq, R., et al. (2017). Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells. Scientific data, Vol.4 (1).

Szakmany, T., Ditai, J., Kirov, M., Protsenko, D., Osinaike, B., Venara, A., Demartines, N., Hubner, M., Pearse, R.M. & Prowle, J.R., et al. (2017). In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study. European journal of surgical oncology, Vol.43 (12), pp. 2324-2332.

Swain, A. (2017). Ductal sex determination. Science, Vol.357 (6352), pp. 648-648.

Pearson, A., Smyth, E., Babina, I.S., Herrera-Abreu, M.T., Tarazona, N., Peckitt, C., Kilgour, E., Smith, N.R., Geh, C., Rooney, C., et al. (2016). High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. Cancer discovery, Vol.6 (8), pp. 838-851.

(2016). Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries. British journal of anaesthesia, Vol.117 (5), pp. 601-609.

Francis, J.C., Melchor, L., Campbell, J., Kendrick, H., Wei, W., Armisen-Garrido, J., Assiotis, I., Chen, L., Kozarewa, I., Fenwick, K., et al. (2015). Whole-exome DNA sequence analysis ofBrca2- andTrp53-deficient mouse mammary gland tumours. The journal of pathology, Vol.236 (2), pp. 186-200.

Mateo, J., Carreira, S., Sandhu, S., Miranda, S., Mossop, H., Perez-Lopez, R., Rodrigues, D.N., Robinson, D., Omlin, A., Tunariu, N., et al. (2015). DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. The new england journal of medicine, Vol.373 (18), pp. 1697-1708.

Bryant, S.L., Francis, J.C., Lokody, I.B., Wang, H., Risbridger, G.P., Loveland, K.L. & Swain, A. (2014). Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development. Dev biol, Vol.395 (2), pp. 209-217.  show abstract

Francis, J.C., Thomsen, M.K., Taketo, M.M. & Swain, A. (2013). beta-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive Carcinoma. Plos genetics, Vol.9 (1).

Strochlic, L., Falk, J., Goillot, E., Sigoillot, S., Bourgeois, F., Delers, P., Rouviere, J., Swain, A., Castellani, V., Schaeffer, L., et al. (2012). Wnt4 Participates in the Formation of Vertebrate Neuromuscular Junction. Plos one, Vol.7 (1).

Buaas, F.W., Gardiner, J.R., Clayton, S., Val, P. & Swain, A. (2012). In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development, Vol.139 (24), pp. 4561-4570.  show abstract

Gardiner, J.R., Shima, Y., Morohashi, K.-. & Swain, A. (2012). SF-1 expression during adrenal development and tumourigenesis. Molecular and cellular endocrinology, Vol.351 (1), pp. 12-18.

Tsaousi, A., Williams, H., Lyon, C.A., Taylor, V., Swain, A., Johnson, J.L. & George, S.J. (2011). Wnt4/beta-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening. Circ res, Vol.108 (4), pp. 427-U85.  show abstract

Thomsen, M.K., Ambroisine, L., Wynn, S., Cheah, K.S., Foster, C.S., Fisher, G., Berney, D.M., Møller, H., Reuter, V.E., Scardino, P., et al. (2010). SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer res, Vol.70 (3), pp. 979-987.  show abstract

Francis, J.C., McCarthy, A., Thomsen, M.K., Ashworth, A. & Swain, A. (2010). Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis. Plos genet, Vol.6 (6),  show abstract

Val, P. & Swain, A. (2010). Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development. Mol cell endocrinol, Vol.323 (1), pp. 105-114.

Buaas, F.W., Val, P. & Swain, A. (2009). The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum mol genet, Vol.18 (16), pp. 2989-3001.  show abstract

Thomsen, M.K., Francis, J.C. & Swain, A. (2008). The role of Sox9 in prostate development. Differentiation, Vol.76 (6), pp. 728-735.  show abstract

Thomsen, M.K., Butler, C.M., Shen, M.M. & Swain, A. (2008). Sox9 is required for prostate development. Dev biol, Vol.316 (2), pp. 302-311.  show abstract

Val, P., Martinez-Barbera, J.-. & Swain, A. (2007). Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development, Vol.134 (12), pp. 2349-2358.  show abstract

Val, P., Jeays-Ward, K. & Swain, A. (2006). Identification of a novel population of adrenal-like cells in the mammalian testis. Dev biol, Vol.299 (1), pp. 250-256.  show abstract

Swain, A. (2006). Sex determination: time for meiosis? The gonad decides. Curr biol, Vol.16 (13), pp. R507-R509.  show abstract

Val, P. & Swain, A. (2005). Mechanisms of disease: normal and abnormal gonadal development and sex determination in mammals. Nat clin pract urol, Vol.2 (12), pp. 616-627.  show abstract

Yao, H.H., Matzuk, M.M., Jorgez, C.J., Menke, D.B., Page, D.C., Swain, A. & Capel, B. (2004). Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev dynam, Vol.230 (2), pp. 210-215.  show abstract

Jeays-Ward, K., Dandonneau, M. & Swain, A. (2004). Wnt4 is required for proper male as well as female sexual development. Dev biol, Vol.276 (2), pp. 431-440.  show abstract

Mizusaki, H., Kawabe, K., Mukai, T., Ariyoshi, E., Kasahara, M., Yoshioka, H., Swain, A. & Morohashi, K. (2003). Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by Wnt4 in the female developing gonad. Mol endocrinol, Vol.17 (4), pp. 507-519.  show abstract

Jeays-Ward, K., Hoyle, C., Brennan, J., Dandonneau, M., Alldus, G., Capel, B. & Swain, A. (2003). Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development, Vol.130 (16), pp. 3663-3670.  show abstract

Swain, A. (2002). Vertebrate sex determination: a new player in the field. Curr biol, Vol.12 (17), pp. R602-R603.  show abstract

Hoyle, C., Narvaez, V., Alldus, G., Lovell-Badge, R. & Swain, A. (2002). Dax1 expression is dependent on steroidogenic factor 1 in the developing gonad. Mol endocrinol, Vol.16 (4), pp. 747-756.  show abstract

De Vries, G.J., Rissman, E.F., Simerly, R.B., Yang, L.Y., Scordalakes, E.M., Auger, C.J., Swain, A., Lovell-Badge, R., Burgoyne, P.S. & Arnold, A.P., et al. (2002). A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J neurosci, Vol.22 (20), pp. 9005-9014.  show abstract

Jordan, B.K., Mohammed, M., Ching, S.T., Délot, E., Chen, X.-., Dewing, P., Swain, A., Rao, P.N., Elejalde, B.R. & Vilain, E., et al. (2001). Up-Regulation of WNT-4 Signaling and Dosage-Sensitive Sex Reversal in Humans. The american journal of human genetics, Vol.68 (5), pp. 1102-1109.

Swain, A. (2000). Molecular mechanisms in sex determination and gonadal development. Biol reprod, Vol.62, pp. 83-83.

Swain, A. & Lovell-Badge, R. (1999). Mammalian sex determination: a molecular drama. Gene dev, Vol.13 (7), pp. 755-767.

Swain, A. & Lovell-Badge, R. (1998). Developmental genetics - Too much sex is bad for males. Nature, Vol.396 (6707), pp. 115-+.

Swain, A., Narvaez, V., Burgoyne, P., Camerino, G. & Lovell-Badge, R. (1998). Dax1 antagonizes Sry action in mammalian sex determination. Nature, Vol.391 (6669), pp. 761-767.  show abstract

Swain, A. & Lovell-Badge, R. (1997). A molecular approach to sex determination in mammals. Acta paediatr suppl, Vol.423, pp. 46-49.  show abstract

Swain, A., Zanaria, E., Hacker, A., Lovell-Badge, R. & Camerino, G. (1996). Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Nat genet, Vol.12 (4), pp. 404-409.  show abstract

Morais da Silva, S., Hacker, A., Harley, V., Goodfellow, P., Swain, A. & Lovell-Badge, R. (1996). Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat genet, Vol.14 (1), pp. 62-68.  show abstract

Ikeda, Y., Swain, A., Weber, T.J., Hentges, K.E., Zanaria, E., Lalli, E., Tamai, K.T., Sassone-Corsi, P., Lovell-Badge, R., Camerino, G., et al. (1996). Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. Molecular endocrinology, Vol.10 (10), pp. 1261-1272.

Lokody, I.B., Francis, J.C., Gardiner, J.R., Erler, J.T. & Swain, A. Pten Regulates Epithelial Cytodifferentiation during Prostate Development. Plos one, Vol.10 (6), pp. e0129470-e0129470.


Conferences

Biswas, S., Wood, M., Joshi, A., Bown, N., Strain, L., Kane, P., Martinsson, T., Garrido, J., Campbell, J., Swain, A., et al. (2014). Abstract 5082: Whole-exome sequencing of an adult pituitary atypical teratoid rhabdoid tumor (AT/RT) - A not so simple genome as pediatric AT/RT, Presented at Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA, Epidemiology, .

Buaas, B., Val, P. & Swain, A. (2009). The transcription co-factor Cited2 functions during sex determination and early gonad development, Presented at 16th Annual Conference of the International-Society-of-Development-Biologists, Edinburgh, SCOTLAND. MECHANISMS OF DEVELOPMENT, Vol.126, p.S151.

Bryant, S. & Swain, A. (2009). Retinoic acid is necessary and sufficient for the initiation of prostate development, Presented at 16th Annual Conference of the International-Society-of-Development-Biologists, Edinburgh, SCOTLAND. MECHANISMS OF DEVELOPMENT, Vol.126, p.S177.

Ward, K., Hoyle, C., Brennan, J., Capel, B. & Swain, A. (2002). Wnt4 signalling prevents endothelial and steroidogenic cell migration into developing mouse ovaries, Presented at 42nd Annual Meeting of the American-Society-for-Cell-Biology, SAN FRANCISCO, CALIFORNIA. MOLECULAR BIOLOGY OF THE CELL, Vol.13, p.528A.