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Journal Articles

Tremble, K.C. Stirparo, G.G. Bates, L.E. Maskalenka, K. Stuart, H.T. Jones, K. Andersson-Rolf, A. Radzisheuskaya, A. Koo, B.-. Bertone, P. Silva, J.C. (2021). Sox2 modulation increases naïve pluripotency plasticity. Iscience, Vol.24 (3), pp. 102153-102153.

Radzisheuskaya, A. Shliaha, P.V. Grinev, V.V. Shlyueva, D. Damhofer, H. Koche, R. Gorshkov, V. Kovalchuk, S. Zhan, Y. Rodriguez, K.L. Johnstone, A.L. Keogh, M.-. Hendrickson, R.C. Jensen, O.N. Helin, K. (2021). Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. Molecular cell, Vol.81 (8), pp. 1749-1765.e8.

Damhofer, H. Radzisheuskaya, A. Helin, K. (2021). Generation of locus-specific degradable tag knock-ins in mouse and human cell lines. Star protocols, Vol.2 (2), pp. 100575-100575.

Müller, I. Moroni, A.S. Shlyueva, D. Sahadevan, S. Schoof, E.M. Radzisheuskaya, A. Højfeldt, J.W. Tatar, T. Koche, R.P. Huang, C. Helin, K. (2021). MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nature communications, Vol.12 (1).  show abstract

Pastore, F. Bhagwat, N. Pastore, A. Radzisheuskaya, A. Karzai, A. Krishnan, A. Li, B. Bowman, R.L. Xiao, W. Viny, A.D. Zouak, A. Park, Y.C. Cordner, K.B. Braunstein, S. Maag, J.L. Grego, A. Mehta, J. Wang, M. Lin, H. Durham, B.H. Koche, R.P. Rampal, R.K. Helin, K. Scherle, P. Vaddi, K. Levine, R.L. (2020). PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN. Cancer discovery, Vol.10 (11), pp. 1742-1757.  show abstract

Stuart, H.T. Stirparo, G.G. Lohoff, T. Bates, L.E. Kinoshita, M. Lim, C.Y. Sousa, E.J. Maskalenka, K. Radzisheuskaya, A. Malcolm, A.A. Alves, M.R. Lloyd, R.L. Nestorowa, S. Humphreys, P. Mansfield, W. Reik, W. Bertone, P. Nichols, J. Göttgens, B. Silva, J.C. (2019). Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell stem cell, Vol.25 (3), pp. 388-406.e8.

Radzisheuskaya, A. Shliaha, P.V. Grinev, V. Lorenzini, E. Kovalchuk, S. Shlyueva, D. Gorshkov, V. Hendrickson, R.C. Jensen, O.N. Helin, K. (2019). PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Nature structural & molecular biology, Vol.26 (11), pp. 999-1012.

Garland, W. Comet, I. Wu, M. Radzisheuskaya, A. Rib, L. Vitting-Seerup, K. Lloret-Llinares, M. Sandelin, A. Helin, K. Jensen, T.H. (2019). A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell reports, Vol.29 (7), pp. 1800-1811.e6.

Radzisheuskaya, A. Shlyueva, D. Müller, I. Helin, K. (2016). Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic acids research, Vol.44 (18), pp. e141-e141.

Pedersen, M.T. Kooistra, S.M. Radzisheuskaya, A. Laugesen, A. Johansen, J.V. Hayward, D.G. Nilsson, J. Agger, K. Helin, K. (2016). Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development. The embo journal, Vol.35 (14), pp. 1550-1564.

Stuart, H.T. van Oosten, A.L. Radzisheuskaya, A. Martello, G. Miller, A. Dietmann, S. Nichols, J. Silva, J.C. (2014). NANOG Amplifies STAT3 Activation and They Synergistically Induce the Naive Pluripotent Program. Current biology, Vol.24 (3), pp. 340-346.

Christophorou, M.A. Castelo-Branco, G. Halley-Stott, R.P. Oliveira, C.S. Loos, R. Radzisheuskaya, A. Mowen, K.A. Bertone, P. Silva, J.C. Zernicka-Goetz, M. Nielsen, M.L. Gurdon, J.B. Kouzarides, T. (2014). Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature, Vol.507 (7490), pp. 104-108.

Radzisheuskaya, A. Silva, J.C. (2014). Do all roads lead to Oct4? The emerging concepts of induced pluripotency. Trends in cell biology, Vol.24 (5), pp. 275-284.

dos Santos, R.L. Tosti, L. Radzisheuskaya, A. Caballero, I.M. Kaji, K. Hendrich, B. Silva, J.C. (2014). MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner. Cell stem cell, Vol.15 (1), pp. 102-110.

Davies, O.R. Lin, C.-. Radzisheuskaya, A. Zhou, X. Taube, J. Blin, G. Waterhouse, A. Smith, A.J. Lowell, S. (2013). Tcf15 Primes Pluripotent Cells for Differentiation. Cell reports, Vol.3 (2), pp. 472-484.

Radzisheuskaya, A. Le Bin Chia, G. dos Santos, R.L. Theunissen, T.W. Castro, L.F. Nichols, J. Silva, J.C. (2013). A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nature cell biology, Vol.15 (6), pp. 579-590.

Pasque, V. Radzisheuskaya, A. Gillich, A. Halley-Stott, R.P. Panamarova, M. Zernicka-Goetz, M. Surani, M.A. Silva, J.C. (2012). Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. Journal of cell science, Vol.125 (24), pp. 6094-6104.  show abstract

Posrednik, D.V. Ramanouskaya, T.V. Radzisheuskaya, A.A. Khatkevich, A.A. Goncharevich, A.Y. Cherepovich, V.S. Grinev, V.V. (2011). Structural and thermodynamic features of intergenic and intronic human primary microRNAs. Molecular biology, Vol.45 (3), pp. 508-516.

Theunissen, T.W. Costa, Y. Radzisheuskaya, A. van Oosten, A.L. Lavial, F. Pain, B. Castro, L.F. Silva, J.C. (2011). Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development, Vol.138 (22), pp. 4853-4865.  show abstract

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