Dr Alessandro Vannini studied Biology at the University of Rome "Roma Tre" and undertook his Ph.D. research at IRBM "P. Angeletti" (Merck Research Lab), Rome, focussing on the structural characterisation of quorum-sensing proteins in pathogenic bacteria and of human histone-deacetylases (HDACs).
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For his post-doctoral research, supported by Marie-Curie and EMBO long-term fellowships, he joined Professor Patrick Cramer's laboratory in Munich. Here, he elucidated the architecture of yeast RNA polymerase III, the largest among the three eukaryotic RNA polymerases, and unravelled the molecular basis of its regulation by a stress-responsive factor, by combining X-ray crystallography and cryo-electron microscopy.
In 2012, Dr Vannini joined the ICR as Team Leader in the Division of Structural Biology. He and his team are focusing on the structural and functional characterisation of large macromolecular complexes that assemble at RNA polymerase III -transcribed genes across the eukaryotic genome.