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Dr Albert Antolin

Senior Researcher

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Dr Albert Antolin is a Sir Henry Wellcome Postdoctoral Fellow in the Department of Data Science and Division of Cancer Therapeutics. His research focuses on computational chemical biology methods and resources applied to translational cancer research and drug discovery. Team: Computational Biology and Chemogenomics

Biography and research overview

Dr Albert Antolin is an organic chemist by training (Ramon Llull University, Spain). After working for two years as an in silico medicinal chemist in the pharmaceutical industry, he moved back to academia to pursue a PhD in Pharmacoinformatics (Pompeu Fabra University, Spain). During his PhD, Dr. Antolin pioneered the application of polypharmacology prediction to chemical biology by uncovering distantly-related off-targets of chemical probes. 

After defending his PhD, Dr Antolin was awarded a prestigious Marie Curie Fellowship to join ICR to develop the first objective, quantitative and data-driven resource for the assessment of chemical probes, Probe Miner. He also actively participated in the development of the cancer translational research and drug discovery knowledgebase canSAR.

Next, Dr Antolin secured the prestigious Sir Henry Wellcome Postdoctoral Fellowship to explore the polypharmacology of cancer drugs and their implications for precision oncology. Dr Antolin is currently leading this project in collaboration with scientists at Columbia University (USA) and the Medicines Discovery Catapult (UK) and has already identified potent off-targets of cancer drugs including PARP and HSP90 inhibitors.

Since 2019, Dr Antolin also serves as the Associate Director of Chemoinformatics at the non-profit Chemical Probes Portal to promote the use of high-quality chemical probes and increase the robustness and reproducibility of biomedical research.

Having worked in industry and academia, Dr Antolin is interested in translational research aiming to bridge applied industrial drug discovery and fundamental questions in cancer chemical systems biology.