Research projects

Our research consists of three interwoven themes.

Hypofractionation in prostate cancer

• Using the MR Linac to deliver gold-standard image guided radiotherapy and to establish the benefits of this novel device
• Exploring the role of profound hypofractionation (SBRT in 5 fractions) in intermediate and high risk prostate cancer
• Dose-painting (putting the radiation dose where it has the optimal therapeutic ratio) in moderate and profound hypofractionation
• Exploring the limits of extreme hypofractionation

Radiotherapy for metastatic disease

• Can radiation be used as a systemic therapy in metastatic disease?
• Can radiation provide a method of ablating treatment resistant clones?
• Does irradiating pelvic lymph node microscopic metastases improve outcomes in prostate cancer?

Combining drug treatments with ablative radiotherapy for mutual synergy

• Immunotherapy and radiotherapy are synergistic and combining the two is likely to augment the response of each.
• Radiotherapy may be useful in targeting treatment resistant clones in castration-resistant prostate cancer, prolonging time on systemic therapy and delaying the need for chemotherapy.