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Research projects

Professor John Yarnold, Clinical Academic Radiotherapy Team

Seven open national randomised clinical trials have been initiated by Professor Yarnold, including:

  • Standardisation of Radiotherapy (START) Trial A & Trial B, which in 2013 published 10-year finding

    in Lancet Oncology confirming the safety and efficacy of a three-week schedule compared to a standard five-week regimen for women with early breast cancer.
  • Intensity Modulated Radiotherapy Low Dose (IMPORT-Low) Trial evaluating partial breast radiotherapy in women with low risk of local relapse after breast conservation surgery for early breast cancer.
  • Intensity Modulated Radiotherapy High Dose (IMPORT-High) Trial evaluating dose intensity modulated breast radiotherapy in women with average/high risk of local relapse after breast conservation surgery for early breast cancer.
  • FAST trial evaluating a five-fraction, five-week schedule of curative radiotherapy for women with early breast cancer.
  • HOT II trial testing hyperbaric oxygen in patients suffering bowel symptoms after pelvic radiotherapy for pelvic malignancies. This sham-controlled randomised trial recently published negarive results in Lancet Oncology (2014).
  • FAST-Forward trial testing a five-fraction, one-week schedule of whole breast radiotherapy in 4,000 women with early breast cancer.

These trials are linked to translational research investigating determinants of sensitivity to radiotherapy fraction size and genetic predictors of normal tissue injury.

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