Dr Edward Morris, Structural Electron Microscopy team
Fundamental cellular functions and cell division are regulated by large protein complexes. The pathways regulated by such complexes are often deregulated in cancer and they are targets for the development of anticancer drugs. It is therefore of great importance to fully understand the organisation and mechanism of such protein assemblies.
The Structural Electron Microscopy Team focuses on the use of electron microscopy and image analysis based methods to determine the three-dimensional structure and explain the function of large multi protein complexes. At the moment, our main project areas involve research into the structure of the 26S proteasome and the COP9 signalosome, components of the ubiquitin-proteasome system which plays a vital role in the regulation of cell division and cellular homeostasis.
We also take part in collaborative research with other groups both within and outside the Institute of Cancer Research.