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Research overview

Dr Marco Gerlinger, Translational Oncogenomics team

Our research focuses on the following key questions:

  • How do gastrointestinal cancer genomic landscapes change over time and during spatial tumour expansion?
  • What genetic changes and molecular mechanisms drives chemotherapy and targeted therapy resistance in colorectal and gastro-oesophageal cancers? 
  • Can resistance be reversed or targeted through synthetic lethal approaches?
  • How can we stop or steer drug resistance evolution? Are combination therapies, dose modulated therapies or ctDNA based personalized adaptive therapies optimal?
  • How can we increase the immunogenicity of gastrointestinal cancers in order to maximize the number of patients with GI cancers who benefit from immunotherapy?
  • How can we use precision medicine approaches to improve cure rates in early stage GI cancers?
  • What are the fundamental limits of predictability in precision cancer medicine? 

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Research overview Publications