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Our Research
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About our research
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Informatics at the ICR
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Centres at the ICR
Partnerships with The Royal Marsden
Strategic collaborations
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PhDs for science graduates
PhD projects 2022/23
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NIHR academic training
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All current vacancies
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Help us find tomorrow's cancer treatments
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UK Genetic Prostate Cancer Study
UKGPCS publications
Publications
Homeobox B13 G84E Mutation and Prostate Cancer Risk. 2018 Dec: European Eurology EURURO-8131; No. of Pages 12. Tommy Nyberg a,*, Koveela Govindasami b, Goska Leslie a, Tokhir Dadaev b, Elizabeth Bancroft b,c, Holly Ni Raghallaigh b, Mark N. Brook b, Nafisa Hussain b, Diana Keating b, Andrew Lee a, Romayne McMahon b, Angela Morgan b,c, Andrea Mullen b, Andrea Osborne b, Reshma Rageevakumar b,
The UK Genetic Prostate Cancer Study Collaborators
, Zsofia Kote-Jarai b,y, Rosalind Eeles b,c,y, Antonis C. Antoniou.
Gene and pathway level analyses of germline DNA-repair gene variants and
prostate cancer
susceptibility using the iCOGS-genotyping array.
(2016) Saunders EJ, Dadaev T, Leongamornlert DA, Al Olama AA, Benlloch S, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pasayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau SN, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Teixeira MR, Pandha H, Govindasami K, Muir K;
UK
Genetic
Prostate Cancer
Study
Collaborators; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF, Eeles RA, Kote-Jarai Z.
Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk. (2016). MacInnis RJ1,2, Schmidt DF2, Makalic E2, Severi G3,4,5, FitzGerald LM6, Reumann M7,8, Kapuscinski MK2, Kowalczyk A9,10, Zhou Z11, Goudey B11, Qian G10, Bui QM2, Park DJ12,13, Freeman A2, Southey MC12, Al Olama AA14, Kote-Jarai Z15, Eeles RA, Hopper JL16,17, Giles GG1,2;
UK Genetic Prostate Cancer Study Collaborators.
High burden of copy number alterations and c-MYC amplification in prostate cancer from BRCA2 germline mutation carriers. (2015).
Castro E
1,
Jugurnauth-Little S
2,
Karlsson Q
2,
Al-Shahrour F
3,
Piñeiro-Yañez E
3,
Van de Poll F
4,
Leongamornlert D
2,
Dadaev T
2,
Govindasami K
2,
Guy M
2,
Eeles R
5,
Kote-Jarai Z
2;
UKGPCS
, EMBRACE and IMPACT studies
.
Ann Oncol.
2015 Nov;26(11):2293-300. doi: 10.1093/annonc/mdv356. Epub 2015 Sep 7
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans. (2015)
Amin Al Olama A
,
Dadaev T
,
Hazelett DJ
,
Li Q
,
Leongamornlert D
,
Saunders EJ
,
Stephens S
,
Cieza-Borrella C
,
Whitmore I
,
Benlloch Garcia S
,
Giles GG
,
Southey MC
,
Fitzgerald L
,
Gronberg H
,
Wiklund F
,
Aly M
,
Henderson BE
,
Schumacher F
,
Haiman CA
,
Schleutker J
,
Wahlfors T
,
Tammela TL
,
Nordestgaard BG
,
Key TJ
,
Travis RC
,
Neal DE
,
Donovan JL
,
Hamdy FC
,
Pharoah P
,
Pashayan N
,
Khaw KT
,
Stanford JL
,
Thibodeau SN
,
Mcdonnell SK
,
Schaid DJ
,
Maier C
,
Vogel W
,
Luedeke M
,
Herkommer K
,
Kibel AS
,
Cybulski C
,
Wokołorczyk D
,
Kluzniak W
,
Cannon-Albright L
,
Brenner H
,
Butterbach K
,
Arndt V
,
Park JY
,
Sellers T
,
Lin HY
,
Slavov C
,
Kaneva R
,
Mitev V
,
Batra J
,
Clements JA
,
Spurdle A
,
Teixeira MR
,
Paulo P
,
Maia S
,
Pandha H
,
Michael A
,
Kierzek A
,
Govindasami K
,
Guy M
,
Lophatonanon A
,
Muir K
,
Viñuela A
,
Brown AA
;
PRACTICAL Consortium
;
COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative
;
Australian Prostate Cancer BioResource
;
UK Genetic Prostate Cancer Study Collaborators
;
UK ProtecT Study Collaborators
,
Freedman M
,
Conti DV
,
Easton D
,
Coetzee GA
,
Eeles RA
,
Kote-Jarai Z
.
Hum Mol Genet.
2015 Oct 1;24(19):5589-602. doi: 10.1093/hmg/ddv203. Epub 2015 May 29
Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes.
(2015).
Kote-Jarai Z, Mikropoulos C, Leongamornlert DA, Dadaev T, Tymrakiewicz M, Saunders EJ, Jones M, Jugurnauth-Little S, Govindasami K, Guy M, Hamdy FC, Donovan JL, Neal DE, Lane JA, Dearnaley D, Wilkinson RA, Sawyer EJ, Morgan A;
The UK Genetic Prostate Cancer Study Collaborators
; the ProtecT Study Group, Antoniou AC, Eeles RA. Ann Oncol. 2015 Jan 16. pii: mdv004. Epub ahead of print
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.
(2015).
Amin Al Olama A, Benlloch S, Antoniou AC, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Muir K, Schleutker J, Henderson BE, Haiman CA, Schumacher FR, Pashayan N, Pharoah PD, Ostrander EA, Stanford JL, Batra J, Clements JA, Chambers SK, Weischer M, Nordestgaard BG, Ingles SA, Sorensen KD, Orntoft TF, Park JY, Cybulski C, Maier C, Doerk T, Dickinson JL, Cannon-Albright L, Brenner H, Rebbeck TR, Zeigler-Johnson C, Habuchi T, Thibodeau SN, Cooney KA, Chappuis PO, Hutter P, Kaneva RP, Foulkes WD, Zeegers MP, Lu YJ, Zhang HW, Stephenson R, Cox A, Southey MC, Spurdle AB, FitzGerald L, Leongamornlert D, Saunders E, Tymrakiewicz M, Guy M, Dadaev T, Little SJ, Govindasami K, Sawyer E, Wilkinson R, Herkommer K, Hopper JL, Lophatonanon A, Rinckleb AE, Kote-Jarai Z, Eeles RA, Easton DF;
UK Genetic Prostate Cancer Study Collaborators
/British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1121-9. doi: 10.1158/1055-9965.EPI-14-0317. Epub 2015 Apr 2.PMID:25837820
Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease
.
(2014).
Leongamornlert D, Saunders E, Dadaev T, Tymrakiewicz M, Goh C, Jugurnauth-Little S, Kozarewa I, Fenwick K, Assiotis I, Barrowdale D, Govindasami K, Guy M, Sawyer E, Wilkinson R; UKGPCS Collaborators, Antoniou AC, Eeles R, Kote-Jarai Z.
Br J Cancer.
2014 Mar 18;110(6):1663-72. PMID: 24556621
Commentary on "Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (2014).
Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC; COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative; Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT (Prostate testing for cancer and Treatment) Study. Urol Oncol. Feb; 32(2):211. PMID: 24445293
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. (2013)
. Kote-Jarai Z, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Dadaev T, Jugurnauth-Little S, Ross-Adams H, Al Olama AA, Benlloch S, Halim S, Russel R, Dunning AM, Luccarini C, Dennis J, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock S, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah P, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle A, Clements JA, Teixeira MR, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dicks E, Baynes C, Conroy D, Bojesen SE, Kaaks R, Vincent D, Bacot F, Tessier DC; COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF, Eeles RA
. Hum Mol Genet
. Jun 15;22(12):2520-8. PMID:23535824
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (2013)
. Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC; COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative; Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Kote-Jarai Z, Easton DF.
Nat Genet.
Apr; 45(4):385-91, 391e1-2. PMID:23535732
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. (2013)
.
Amin Al Olama A
,
Kote-Jarai Z
,
Schumacher FR
,
Wiklund F
,
Berndt SI
,
Benlloch S
,
Giles GG
,
Severi G
,
Neal DE
,
Hamdy FC
,
Donovan JL
,
Hunter DJ
,
Henderson BE
,
Thun MJ
,
Gaziano M
,
Giovannucci EL
,
Siddiq A
,
Travis RC
,
Cox DG
,
Canzian F
,
Riboli E
,
Key TJ
,
Andriole G
,
Albanes D
,
Hayes RB
,
Schleutker J
,
Auvinen A
,
Tammela TL
,
Weischer M
,
Stanford JL
,
Ostrander EA
,
Cybulski C
,
Lubinski J
,
Thibodeau SN
,
Schaid DJ
,
Sorensen KD
,
Batra J
,
Clements JA
,
Chambers S
,
Aitken J
,
Gardiner RA
,
Maier C
,
Vogel W
,
Dörk T
,
Brenner H
,
Habuchi T
,
Ingles S
,
John EM
,
Dickinson JL
,
Cannon-Albright L
,
Teixeira MR
,
Kaneva R
,
Zhang HW
,
Lu YJ
,
Park JY
,
Cooney KA
,
Muir KR
,
Leongamornlert DA
,
Saunders E
,
Tymrakiewicz M
,
Mahmud N
,
Guy M
,
Govindasami K
,
O'Brien LT
,
Wilkinson RA
,
Hall AL
,
Sawyer EJ
,
Dadaev T
,
Morrison J
,
Dearnaley DP
,
Horwich A
,
Huddart RA
,
Khoo VS
,
Parker CC
,
Van As N
,
Woodhouse CJ
,
Thompson A
,
Dudderidge T
,
Ogden C
,
Cooper CS
,
Lophatonanon A
,
Southey MC
,
Hopper JL
,
English D
,
Virtamo J
,
Le Marchand L
,
Campa D
,
Kaaks R
,
Lindstrom S
,
Diver WR
,
Gapstur S
,
Yeager M
,
Cox A
,
Stern MC
,
Corral R
,
Aly M
,
Isaacs W
,
Adolfsson J
,
Xu J
,
Zheng SL
,
Wahlfors T
,
Taari K
,
Kujala P
,
Klarskov P
,
Nordestgaard BG
,
Røder MA
,
Frikke-Schmidt R
,
Bojesen SE
,
FitzGerald LM
,
Kolb S
,
Kwon EM
,
Karyadi DM
,
Orntoft TF
,
Borre M
,
Rinckleb A
,
Luedeke M
,
Herkommer K
,
Meyer A
,
Serth J
,
Marthick JR
,
Patterson B
,
Wokolorczyk D
,
Spurdle A
,
Lose F
,
McDonnell SK
,
Joshi AD
,
Shahabi A
,
Pinto P
,
Santos J
,
Ray A
,
Sellers TA
,
Lin HY
,
Stephenson RA
,
Teerlink C
,
Muller H
,
Rothenbacher D
,
Tsuchiya N
,
Narita S
,
Cao GW
,
Slavov C
,
Mitev V
;
UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology
;
UK ProtecT Study Collaborators
;
Australian Prostate Cancer Bioresource
;
PRACTICAL Consortium
,
Chanock S
,
Gronberg H
,
Haiman CA
,
Kraft P
,
Easton DF
,
Eeles RA
.
Hum Mol Genet,
Jan 15. PMID:23065704
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. (2013)
. Kote-Jarai Z, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Dadaev T, Jugurnauth-Little S, Ross-Adams H, Al Olama AA, Benlloch S, Halim S, Russel R, Dunning AM, Luccarini C, Dennis J, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock S, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah P, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle A, Clements JA, Teixeira MR, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dicks E, Baynes C, Conroy D, Bojesen SE, Kaaks R, Vincent D, Bacot F, Tessier DC; COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF, Eeles RA
. Hum Mol Genet
. Jun 15;22(12):2520-8. PMID:23535824
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (2013)
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Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics.
(2006)
Schaid DJ, McDonnell SK, Zarfas KE, Cunningham JM, Hebbring S, Thibodeau SN, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Badzioch M, Bishop DT, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Guy M, Hsieh CL, Halpern J, Balise RR, Oakley-Girvan I, Whittemore AS, Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Friedrichsen DM, Deutsch K, Kolb S, Janer M, Hood L, Ostrander EA, Stanford JL, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Lange EM, Ho LA, Beebe-Dimmer JL, Wood DP, Cooney KA, Seminara D, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TL, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Grönberg H, Camp NJ, Farnham J, Cannon-Albright LA, Catalona WJ, Suarez BK, Roehl KA.
Human Genetics
, 120:471-85.
Description of the International Consortium for Prostate Cancer Genetics, and failure to replicate linkage of hereditary prostate cancer to 20q13.
(2005)
Schaid DJ, Chang BL and The International Consortium for Prostate Cancer Genetics (ICPCG) and ACTANE consortium: Eeles R, Edwards S, Hope Q, Bullock S et al.
The Prostate
, 63:276-290.
Association between hormonal genetic polymorphisms and early-onset prostate cancer.
(2005)
Forrest MS, Edwards SM, Houlston R, Kote-Jarai Z, KeyT, Allen N, Knowles MA, Turner F, Ardern-Jones A, Murkin A, Williams S, Oram R, CR-UK/BPG UK prostate cancer study collaborators, Bishop DT and Eeles RA.
Prostate Cancer Prostatic Diseases
, 8:95-102.
A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics.
(2005)
Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Hsieh CL, Halpern J, Balise RN, Oakley-Girvan I, Whittemore AS, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Thibodeau SN, McDonnell SK, Cunningham JM, Zarfas KE, Hebbring S, Schaid DJ, Friedrichsen DM, Deutsch K, Kolb S, Badzioch M, Jarvik GP, Janer M, Hood L, Ostrander EA, Stanford JL, Lange EM, Beebe-Dimmer JL, Mohai CE, Cooney KA, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TLj, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Gronberg H, Camp NJ, Farnham J, Cannon-Albright LA, Seminara D, ACTANE Consortium.
American Journal of Human Genetics
,77:219-29.
Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer.
(2005)
Hope Q, Bullock S, Evans C, Meitz J, Hamel N, Edwards SM, Severi G, Dearnaley D, Jhavar S, Southgate C, Falconer A, Dowe A, Muir K, Houlston RS, Engert JC, Roquis D, Sinnett D, Simard J, Heimdal K, Moller P, Maehle L, Badzioch M, Eeles RA, Easton DF, English DR, Southey MC, Hopper JL, Foulkes WD, Giles GG; The Cancer Research UK/British Association of Urological Surgeons’ Section of Oncology Collaborators.
Cancer Epidemiology Biomarkers & Prevention
. 14:397-402.
ATM polymorphisms as risk factors for prostate cancer development.
(2004)
Angèle S, Falconer A, Edwards SM, Dörk T, Bremer M, Moullan N, Chapot B, Muir K, Houlston R, Norman AR, Bullock S, Hope Q, Meitz J, Dearnaley D, Dowe A, Southgate C, Ardern-Jones A, Easton DF, Eeles RA, Hall J.
British Journal of Cancer
, 91: 783-87.
ATM over-expression in prostate tumours: possible role in telomere maintenance.
(2004)
Angèle S, Falconer A, Foster CS, Taniere P, Eeles RA & Hall J.
American Journal of Clinical Pathology
. 121: 231-6.
Results of a Genome-Wide Linkage Analysis in Prostate Cancer Families Ascertained Through the ACTANE Consortium
.
(2003)
Edwards S, Meitz J, Eeles R, Evans C, Easton D, Hopper J, Giles G, Foulkes WD, Narod S, Simard J, Badzioch M, Mahle L, The International ACTANE Consortium.
The Prostate,
57: 270-79.
Germline mutations in fumarate hydratase (FH) do not predispose to prostate cancer.
(2003)
Bevan S, Edwards SM, Ardern-Jones A, Dowe A, Southgate C, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, Dearnaley D, Easton DF, Eeles RA, Houlston RS.
Prostate Cancer Prostatic Diseases
6: 12-4.
Association between Leptin Receptor Gene Polymorphisms and Early Onset Prostate Cancer.
Kote-Jarai Z, Singh R, Durocher F, Easton D, Edward SM, Ardern-Jones A, Dearnaley DP, Houlston R, Kirby R, Eeles R
(2003)
British Journal of Urology International
, 92:109-12.
Two percent of men with early onset prostate cancer harbour germline mutations in the
BRCA2
gene.
(2003)
Edwards SM, Kote-Jarai Z, Meitz J, Hamoudi R, Hope Q, Osin P, Jackson R, Southgate C, Singh R, Falconer A, Dearnaley D, Ardern-Jones A, Murkin A, Dowe A, Kelly J, Williams S, Oram R, Stevens M, Teare D, Ponder B, Gayther S, The CRC/BPG UK Familial Prostate Cancer Study Collaborators/BAUS Section of Oncology, Easton DF & Eeles RA.
American Journal of Human Genetics
, 72:1-12.
Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer
. Kote-Jarai Z, Durocher F, Edwards SM, Hamoudi R, Jackson RA, Ardern-Jones A, Murkin A, Dearnaley DP, Houlston R, The CRC/BPG UK Familial Prostate Cancer Collaborators, Easton DF, & Eeles RA.
Prostate Cancer and Prostatic Diseases
, 5:189-92.
Influence of cytokine polymorphisms on the development of prostate cancer.
(2002)
McCarron SL, Edwards S, Evans PR, Gibbs R, Dearnaley D, Dowe A, Southgate C, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, Easton DF, Eeles RA & Howell WM.
Cancer Research
, 62:3369-72.
HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease.
(2002)
Meitz J, Edwards S, Easton D, Murkin A, Ardern-Jones A, Jackson R, Williams S, Dearnaley D, Stratton M, Houlston R, The CRC/BPG UK Familial Prostate Cancer Study Collaborators & Eeles RA.
British Journal of Cancer,
87:905-8.
Relationship between Glutathione S-Transferase M1, P1, and T1 polymorphisms and early onset prostate cancer.
(2001)
Kote-Jarai Z, Easton D, Edwards SM, Jefferies S, Jackson RA, Ardern-Jones A, Murkin A, Durocher F, Dearnaley DP, Singh R, Shearer R, Kirby R, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, Houlston R, Eeles RA.
Pharmacogenetics
, 11:325-30.
No evidence of germline
PTEN
mutations in familial prostate cancer.
(2000)
Forrest MS, Edwards SM, Hamoudi RA, Dearnaley DP, Ardern-Jones A, Dowe A, Murkin A, Kelly J, Teare MD, Easton DF, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, The EC BIOMED Familial Prostate Cancer Study Collaborators, Knowles MA, Bishop DT & Eeles RA.
Journal of Medical Genetics
, 37:210-12.
Combined analysis of hereditary prostate cancer linkage to 1q24-25: results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics.
(2000)
Jianfeng Xu & International Consortium for Prostate Cancer Genetics (ICPCG) incl Eeles RA.
American Journal of Human Genetics
, 66:945-57.
No evidence of linkage to chromosome 1q42.2-43 in 131 prostate cancer families from the ACTANE consortium.
(2000)
Singh R and The ACTANE Consortium & Eeles RA.
British Journal of Cancer
, 83:1654-8.
Suggestive evidence for a site specific prostate cancer gene on 1p36.
(2000)
Badzioch M, Eeles R, Leblanc G, Foulkes WD, Giles G, Edwards S, Goldgar D, Hopper JL, Bishop DT, Moller P, Heimdahl K, Easton D, The CRC/BPG Familial Prostate Cancer Study Coordinators and Collaborators, The EU Biomed Collaborators, Simard J. Journal of Medical Genetics 37:947-8.
The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer.
(2000)
Gayther SA, de Foy KAF, Harrington P, Pharoah P, Dunsmuir WD, Edwards SM, Gillett C, Ardern-Jones A, Dearnaley DP, Easton DF, Ford D, Shearer RJ, Kirby RS, Dowe AL, Kelly J, Stratton MR, The CRC/BPG United Kingdom Familial Prostate Cancer Study Collaborators, Ponder BAJ, Barnes D and Eeles RA. Cancer Research, 60: 4513-18.
High Risk Genes Predisposing to Prostate Cancer Development – Do they Exist?
(2000)
Singh R, Eeles RA, Durocher F, Simard J, Edwards SM, Badzioch M, Kote-Jarai Z, Teare D, Ford D, Dearnaley DP, Ardern-Jones A, Murkin A, Dowe A, Shearer R, Kelly J, Labrie F, The CRC/BPG UK Familial Prostate Cancer Collaborators, Easton D, Narod A, Tonin PN, Foulkes W. Prostate Cancer & Prostatic Diseases, 3:241-7.
Genetic predisposition to prostate cancer.
(1999)
Eeles RA, the UK Familial Prostate Study Co-ordinating Group & the CRC/BPG UK Familial Prostate Cancer Study Collaborators Prostate Cancer & Prostatic Diseases 2: 9-15.
Linkage analysis of chromosome 1q markers in 136 prostate cancer families.
(1998)
Eeles RA, Durocher F, Edwards S, Teare D, Badzioch M, Hamoudi R, Gill S, Biggs P, Dearnaley D, Ardern-Jones A, Dowe A, Shearer R, McLennan DL, Norman RW, Ghadirian P, Aprikian A, Ford D, Amos C, King TM, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, Labrie F, Simard J, Narod S, Easton D & Foulkes W. American Journal of Human Genetics, 62: 653-8.
Immunohistochemical expression of BRCA2 protein and allelic loss at the
BRCA
2 locus in prostate cancer.
(1998)
Edwards SM, Dunsmuir WD, Gillett C, Lakhani SR, Corbishley C, Young M, Kirby RS, Dearnaley DP, Dowe A, Ardern-Jones A, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, Barnes D & Eeles RA. International Journal of Cancer 78:1-7.
Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus,
HPC
1
.
(1998)
Dunsmuir WD, Edwards SM, Lakhani SR, Young M, Corbishley C, Kirby RS, Dearnaley DP, Dowe A, Ardern-Jones A, Kelly J, The CRC/BPG UK Familial Prostate Cancer Study Collaborators & Eeles RA. British Journal of Cancer 78:1430-3.
No germline mutations in the dimerization domain of
MXI
1 in prostate cancer clusters.
(1997)
Edwards S, Dearnaley DP, Ardern-Jones A, Hamoudi R, Easton DF, Ford D, Shearer R, Dowe A, CRC/BPG UK Familial Prostate Cancer Study & Eeles RA. British Journal of Cancer, 76: 992-1000.
Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study.
(1997)
Eeles RA, Dearnaley DP, Ardern-Jones A, Shearer RJ, Easton DF, Ford D, Edwards S & Dowe A. British Journal of Urology, 79: 8-14.