Image: An immunohistochemical image of Ki67 staining. Credit: Endocrinology Team, Professor Mitch Dowsett
The interests of the team are focused almost entirely on translational breast cancer research with an emphasis on endocrine aspects and biomarker analyses.
Our main goal is to identify the mechanisms by which oestrogens enhance the progression of oestrogen receptor positive breast cancer, and to use that information for improved targeted therapy.
We also conduct work to enhance the clinical use of biomarkers to predict benefit from treatment and long-term clinical outcome.
Additionally our endocrine expertise is an important asset for several collaborations with groups involved in the epidemiology of breast cancer, most notably now with the Breakthrough Generations Study.
Image: Schematic representation of POETIC clinical trial design (PeriOperative Endocrine Therapy for Individualised Care). Credit: Endocrinology Team, Professor Mitch Dowsett