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Research overview

Dr Nick Orr, Complex Trait Genetics team

Complex traits, including susceptibility to most common types of cancer, are influenced by a combination of genetic and environmental factors.

We characterise risk factors for breast cancer by utilising data and biological materials collected from participants in the Breakthrough Generations Study and the Breakthrough Male Breast Cancer Study. In particular, we aim to gain a better understanding of the aetiology and biology of breast cancer by exploring gender-specific similarities and differences in the mechanisms by which inherited genetic variation influences risk of the disease.

In addition, we are initiating pharmacogenetic studies that explore the contributions of genetics to adverse drug reactions and response to treatment in cancer patients.

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