QUEST
Two phase III, randomised controlled, multicentre trials, conducted in parallel, to assess the impact of the type (Trial A) and timing (Trial B) of latissimus dorsi (LD) breast reconstruction on the quality of life (QoL) of women following mastectomy for early breast cancer.
Disease site: Breast cancer
Treatment modality: Surgery
Status: Closed
Trial details
Key issues in immediate breast reconstruction (IBR) were identified which led to a systematic review of all breast reconstructions with QoL as endpoints undertaken. The conclusion from this review was that there is a pressing need for further evidence in the form of well-designed multicentre studies or trials using specific QoL measures and adequate sample sizes. The rationale behind the QUEST trials it to provide breast reconstruction that will confer optimal health-related QoL benefit and patient satisfaction for women facing mastectomy.
Chief Investigator: Dr Zoë E Winters, University Hospitals Bristol NHS Foundation Trust
ICR-CTSU Scientific Lead: Professor Judith Bliss
Trial management contact: [email protected]
ISRCTN: Trial A: 38846532 Trial B: 92581226
Sponsor: University Hospitals Bristol NHS Foundation Trust
Funding: Cancer Research UK (CRUK/08/027), BUPA Foundation
Further information
View QUEST A and QUEST B on the National Institute for Health Research website: NIHR - Be Part Of Research
Patient friendly information on QUEST A and QUEST B is available at Cancer Research UK.
Publications and presentations
Mills J, Emson M, Bliss J, Winters Z. The development of a DVD to aid patients' understanding of surgical breast reconstruction clinical trials: QUEST A & B. Trials 2011;12(Suppl 1):#A85
Mills J, Emson M, Bliss J, Winters Z. The development of a DVD to aid patients' understanding of surgical breast reconstruction clinical trials: QUEST A & B. Eur. J. Surg. Oncol. 2010;36(11):1123
Winters Z, Emson M, Bliss J, Mills J. The development of a DVD to aid patients' understanding of surgical breast reconstruction clinical trials: QUEST A & B. NCRI National Cancer Conference; 2010; Liverpool.
Winters Z, Mills J, Kilburn LS, Horne R, Hitchins J, Bliss J. The QUEST Trial (CRUK/08/027): A multi-centre randomised trial to assess the impact of the type and timing of breast reconstruction on quality of life following mastectomy. Eur J Cancer Supplements 2010;8(3):142 #289
Winters Z, Mills J, Kilburn LS, Horne R, Hitchins J, Bliss J. The QUEST Trial (CRUK/08/027): A multi-centre randomised trial to assess the impact of the type and timing of breast reconstruction on quality of life following mastectomy. NCRI National Cancer Conference; 2009; Birmingham.
Potter S, Kilburn L, Bliss J, Winters ZE. The QUEST feasibility study: A novel clinicl trial to evaluate the impact of the type and timing of breast reconstruction on quality of life following mastectomy. Oncoplastic & Reconstructive Breast Surgery (ORBS) Conference; 2008 23-24th September; Nottingham.