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Photo-dynamic versus white light-guided treatment of non-muscle invasive bladder cancer: randomised phase III trial of clinical and cost-effectiveness

Disease site: Bladder cancer

Treatment modality: Surgery

Status: In follow-up

Trial details

PHOTO is a pragmatic, multicentre, randomised controlled phase III trial, investigating the efficacy of using photo-dynamic diagnosis (PDD) under blue light – instead of white light – for transurethral resection of bladder tumour (TURBT) in intermediate and high risk non-muscle invasive bladder cancer.

533 patients will be recruited from UK sites. Half of the participants will undergo surgery using PDD under blue light. The other participants will undergo surgery using standard white light. All participants will be followed up regularly during the three year trial period.

The PHOTO trial is managed by ICR and CHaRT.

Further information

Chief Investigator: Mr Rakesh Heer, The Newcastle upon Tyne Hospitals NHS Foundation Trust

ICR-CTSU Scientific Lead: Prof Emma Hall

Trial management contacts: [email protected] and [email protected]


Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust

Funding: National Institute for Health Research

View PHOTO on the UK Clinical Trials Gateway.

Read a plain English summary of PHOTO from Cancer Research UK.

Publications and presentations

There have been no presentations or publications to date

Clinical trials

Division of Clinical Studies

The division carries out or coordinates high-quality trials and translational research at both an early phase – typically to test new targeted drugs – and a later stage.