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COSTAR: A Multicentre Randomised Study of Cochlear Sparing Intensity Modulated Radiotherapy Versus Conventional Radiotherapy in Patients with Parotid Tumours. 

Disease site: Head and neck

Treatment modality: Radiotherapy

Status: In active follow-up

Trial details

COSTAR is a phase III multi-centre randomised controlled trial designed to demonstrate a difference in the proportion of patients suffering sensori-neural hearing loss of at least 10dB in bone conduction at 4000 Hz, as assessed by an audiogram done 12 months post radiotherapy, in patients treated with cochlea-sparing IMRT and conventional radiotherapy.

The work is supported by the NCRI CTrad Group and the NCRI Head and Neck Cancer Studies Group.

Chief Investigator: Dr Chris Nutting, The Royal Marsden NHS Foundation Trust

ICR-CTSU Scientific Lead: Dr Emma Hall

Trial management contact: Mark Sydenham - Trial Manager, [email protected]

ISRCTN: 81772291

Sponsor: The Royal Marsden NHS Foundation Trust

Funding: Cancer Research UK (CRUK/08/004)

Further information

Further information on the COSTAR trial may be found on the following sites:

Accrual figures are available from the UK Clinical Trials Gateway

Patient friendly information on the COSTAR trial at CancerHelp UK

Clinical trials

Division of Clinical Studies

The division carries out or coordinates high-quality trials and translational research at both an early phase – typically to test new targeted drugs – and a later stage.