Cancers develop partly through genetic abnormalities within cells of the body. Colorectal cancer is a major cause of death worldwide, but we don’t yet have a full understanding of the genetic changes that cause it to grow. New research – published today in Nature – delivers an unprecedented view of the genetic landscape of CRC and its responses to treatment.

Researchers have mapped the exact variants in a gene that dramatically increase a person’s risk of developing several types of cancer. This could lead to improved early detection and targeted treatment across diverse populations.

Scientists have added to the list of inherited genetic mutations known to increase the risk of more aggressive prostate cancer.