Identification of novel tissue and circulating biomarkers of anti-tumoral immune response and identification of novel drug targets in locally-advanced head and neck squamous cell carcinoma (LA-HNSCC)

• Primary supervisor: Dr Shreerang Bhide (ICR)
• Primary Division: Radiotherapy and Imaging
• Primary team: Targeted therapy

Project summary

Targeting inflammatory cell mediated fuelling of prostate cancer

• Primary supervisor: Johann de Bono (ICR)
• Primary Division: Clinical Studies
• Primary team: Prostate Cancer Targeted Therapy Group

Project summary

Decreasing the burden of cancer (early detection in high risk groups with a genetic predisposition and identification of new methods of screening)

• Primary supervisor: Ros Eeles (ICR)
• Primary Division: Genetics and Epidemiology
• Primary team: Oncogenetics

Project summary

ctDNA guided optimisation of chemotherapy in colorectal cancer using evolutionary genomics

• Primary supervisor: Trevor Graham (ICR)
• Primary Division: Molecular Pathology/Centre for Cancer Evolution
• Primary team: Genomics and Evolutionary Dynamics

Project summary

Lung cancer early detection: novel liquid biopsy technologies with a metabolomics focus

• Primary supervisor: Richard Lee (ICR)
• Primary Division: Genetics and Epidemiology
• Primary team: Early Diagnosis and Detection Team

Project summary

Bone marrow microenvironment remodelling and innate immunity signalling pathways in acute myeloid leukaemia patient responses

• Primary supervisor: Cristina Lo Celso (Imperial)
• Primary Faculty: Natural Sciences
• Primary Department: Life Sciences/Immunology and Inflammation

Project summary

Molecular and imaging biomarkers for prostate cancer 

• Primary supervisor: Stephen Mangar (Imperial)
• Primary Faculty: Medicine
• Primary Department: Radiotherapy

Project summary

Super-resolution imaging to assess epigenetic evolution in ovarian high grade serous carcinoma

• Primary supervisor: Iain McNeish (Imperial)
• Primary Faculty: Medicine
• Primary Department: Surgery and Cancer

Project summary

Investigating and targeting the sub-clonal dynamics of therapy resistance in metastatic invasive lobular breast cancer

• Primary supervisor: Rachael Natrajan (ICR)
• Primary Division: Breast Cancer
• Primary team: Functional Genomics

Project summary

Drivers of metastasis and recurrence in head and neck and gynaecological squamous cell carcinomas

• Primary supervisor: Ben O'Leary (ICR)
• Primary Division: Radiotherapy and Imaging/Centre for Cancer Evolution
• Primary team: Targeted Therapy

Project summary

Development of a disruptive artificial intelligence-based multi-modal companion diagnosis for precise combination cancer immunotherapies

• Primary supervisor: Anguraj Sadanandam (ICR)
• Primary Division: Molecular Pathology
• Primary team: Systems and Precision Cancer Medicine

Project summary

Improving patient outcomes by circumventing treatment resistance in lethal prostate cancer

• Primary supervisor: Adam Sharp (ICR)
• Primary Division: Clinical Studies
• Primary team: Translational Therapeutics Team

Project summary

The development of novel fluorescence and radiolabelled markers in gastrointestinal stromal tumour (GIST) and evaluation of their use perioperative assessment and fluorescence guided surgery

• Primary supervisor: Myles Smith (ICR)
• Primary Division: Radiotherapy and Imaging/Academic Surgery
• Primary team: Melanoma and Rare Tumour Surgery Team

Project summary

Harnessing the immunogenic potential of radiotherapy for maximum impact in high-risk hormone positive breast cancer patients – translational research linked to neo-adjuvant radiotherapy trials

• Primary supervisor: Navita Somaiah (ICR)
• Primary Division: Radiotherapy and Imaging
• Primary team: Translational Breast Radiobiology

Project summary

Incorporating uncertainty information into artificial intelligence auto-contouring approaches for radiotherapy planning

• Primary supervisor: Alexandra Taylor (ICR)
• Primary Division: Radiotherapy and Imaging
• Primary team: Radiotherapy for Gynaecological Cancer

Project summary

Developing a miniaturised robotics platform with integrated real-time metabolomics for first-in-human enhanced minimally invasive surgery in head and neck cancer

• Primary supervisor: Burak Temelkuran (Imperial)
• Primary Faculty: Medicine
• Primary Department: Metabolism, Digestion and Reproduction

Project summary

Massive germline exome sequencing to identify novel breast cancer susceptibility genes

• Primary supervisor: Clare Turnbull (ICR)
• Primary Division: Genetics and Epidemiology
• Primary team: Translational Genetics

Project summary

Analysing gene expression changes with liquid biopsies to identify mechanisms of resistance to breast cancer treatment

• Primary supervisor: Nicholas Turner (ICR)
• Primary Division: Breast Cancer
• Primary team: Molecular Oncology

Project summary

Using argumentation-based eXplainable AI to integrate large, shallow and small detailed datasets in palliative radiotherapy

• Primary supervisor: Matt Williams (Imperial)
• Primary Division: Surgery and Cancer
• Primary team: Cancer

Project summary

Discovering novel immunogenic peptides induced by aberrant splicing in breast cancer

• Primary supervisor: Luis Zapata (ICR)
• Primary Division: Molecular Pathology
• Primary team :Evolutionary Genomics and Modelling

Project summary

Previous projects 

Predictors of lung cancer response to immunotherapy
William Cookson (Imperial)

Targeting inflammatory cell mediated fuelling of prostate cancer
Johann de Bono (ICR)

T-cell phenotypes and dynamics in gastro-oesophageal cancer immunotherapy
Marco Gerlinger (ICR)

Developing integrative biomarkers for improving neoadjuvant therapy in high-risk soft tissue sarcoma
Paul Huang (ICR)

Immunoengineering strategies for biomimetic silicone implant design to mitigate the risk of radiotherapy-induced capsular contracture in implant-based breast reconstruction
Aadil Khan (ICR/RMH)

Understanding Role of Tumour Heterogeneity and Evolution in treatment resistance in Aggressive Thyroid Cancers: utility of circulating free tumour DNA (ctDNA)
Dae Kim (ICR/RMH)

Neuroendocrine markers in colorectal adenocarcinomas
Christos Kontovounisios (Imperial)

Investigation of Immune and Microbiome Disruption as drivers of mutagenic pathways in Oesophago-Gastric Cancer
Sacheen Kumar (ICR)

Management of cancer risk in people with Lynch Syndrome and a Family History of Colorectal Cancer (CRC)
Kevin Monahan (Imperial)

Radiogenomics and hepatocellular cancer
Rohini Sharma (Imperial)

Determinants of toxicity in prostate radiotherapy
Alison Tree (ICR/RMH)

Deciphering cancer evolution through post-mortem profiling
Samra Turajlic (ICR/RMH/Crick)

Massive germline exome sequencing to identify novel breast cancer susceptibility genes
Clare Turnbull (ICR)

Predicting and targeting neoantigens associated with BRCA1/2 reversion mutations in PARP inhibitor and platinum-resistant breast cancer
Andrew Tutt (ICR)

Mechanistic exploration of cell-free tumour DNA (ctDNA) shedding into circulation using microfluidic vascularised organoid-on-chip models
Nicola Valeri (Imperial)