Project Proposals

Project 1 – Predictors of Lung Cancer response to immunotherapy

• Primary Supervisor: Prof. William Cookson (Imperial)
• Other members of the supervisory team: Prof. Alan Melcher (ICR), Prof. Miriam Moffatt (Imperial), Prof. Andrew Nicholson (Imperial)
• Primary Division or Faculty: National Heart and Lung Institute
• Primary Team or Department: Genomic Medicine

Project 2 – Targeting inflammatory cell mediated fuelling of prostate cancer

• Primary Supervisor: Professor Johann de Bono (ICR, Sutton)
• Other members of the supervisory team: Dr Adam Sharp (ICR)
• Primary Division or Faculty: Clinical Studies
• Primary Team or Department: PCTTG

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Project 3 – T-cell phenotypes and dynamics in gastro-oesophageal cancer immunotherapy

• Primary Supervisor: Dr Marco Gerlinger (ICR, Chelsea)
• Other members of the supervisory team: Prof Jyoti Choudhary (ICR)
• Primary Division or Faculty: Molecular Pathology
• Primary Team or Department: Translational Oncogenomics Lab

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Project 4 – Developing integrative biomarkers for improving neoadjuvant therapy in high-risk soft tissue sarcoma

• Primary Supervisor: Dr Paul Huang (ICR, Sutton)
• Other members of the supervisory team: Professor Robin Jones (ICR)
• Primary Division or Faculty: Molecular Pathology
• Primary Team or Department: Molecular & Systems Oncology Team

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Project 5 – Immunoengineering strategies for biomimetic silicone implant design to mitigate the risk of radiotherapy-induced capsular contracture in implant-based breast reconstruction

• Primary Supervisor: Mr Aadil Khan (ICR, Chelsea)
• Other members of the supervisory team: Dr Adam Celiz (Imperial), Dr Sheeba Irshad (KCL), Prof Kevin Harrington (ICR)
• Primary Division or Faculty: Radiotherapy & Imaging
• Primary Team or Department: Targeted Therapy Team

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Project 6 – Understanding Role of Tumour Heterogeneity and Evolution in treatment resistance in Aggressive Thyroid Cancers: utility of circulating free tumour DNA (ctDNA)

• Primary Supervisor: Prof Dae Kim (ICR, RMH, Chelsea)
• Other members of the supervisory team: Dr Kate Newbold (ICR, RMH), Dr Rob Hynds (CRICK), Prof Kevin Harrington (ICR)
• Primary Division or Faculty: Radiotherapy & Imaging
• Primary Team or Department: Head & Neck

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Project 7 – Neuroendocrine markers in colorectal adenocarcinomas

• Primary Supervisor: Mr Christos Kontovounisios (Imperial)
• Other members of the supervisory team: Professor ParisTekkis (Imperial), Dr Irene Chong (ICR, RMH)
• Primary Division or Faculty: Surgery and Cancer
• Primary Team or Department: Surgery

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Project 8 – Investigation of Immune and Microbiome Disruption as drivers of mutagenic pathways in Oesophago-Gastric Cancer

• Primary Supervisor: Mr Sacheen Kumar (ICR, Chelsea)
• Other members of the supervisory team: Dr. Aran Singanayagam (Imperial)
• Primary Division or Faculty: Radiotherapy & Imaging
• Primary Team or Department: Upper GI Surgical Oncology

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Project 9 – Management of cancer risk in people with Lynch Syndrome and a Family History of Colorectal Cancer (CRC)

• Primary Supervisor: Dr Kevin Monahan (SMH, Harrow)
• Other members of the supervisory team: Prof Huw Thomas (Imperial), Dr Andrew Latchford (SMH)
• Primary Division or Faculty: Medicine
• Primary Team or Department: Lynch Syndrome Clinic

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Project 10 – Radiogenomics and hepatocellular cancer

• Primary Supervisor: Dr Rohini Sharma (Imperial)
• Other members of the supervisory team: Prof Eric Aboagye (Imperial)
• Primary Division or Faculty: Medicine
• Primary Team or Department: Surgery and Cancer

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Project 11 – Determinants of toxicity in prostate radiotherapy

• Primary Supervisor: Dr Alison Tree (ICR, RMH, Sutton)
• Other members of the supervisory team: Dr Nicholas van As (ICR, RMH), Dr Julia Murray (ICR, RMH), Prof Emma Hall (ICR)
• Primary Division or Faculty: Radiotherapy and Imaging

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Project 12 – Deciphering cancer evolution through post-mortem profiling

• Primary Supervisor: Dr Samra Turajlic (ICR, RMH, CRICK)
• Other members of the supervisory team: Dr Kevin Litchfield (UCL), Prof James Larkin (ICR, RMH)
• Primary Division or Faculty: Clinical Studies (ICR)
• Primary Team or Department: Cancer Dynamics (FCI)

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Project 13 – Massive germline exome sequencing to identify novel breast cancer susceptibility genes

• Primary Supervisor: Prof Clare Turnbull (ICR, Sutton)
• Other members of the supervisory team: Dr Kostas Tsilidis (Imperial), Professor Marc Gunter (Imperial, IARC)
• Primary Division or Faculty: Genetics and Epidemiology
• Primary Team or Department: Translational Cancer Genetics

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Project 14 – Predicting and targeting neoantigens associated with BRCA1/2 reversion mutations in PARP inhibitor and platinum-resistant breast cancer

• Primary Supervisor: Prof Andrew Tutt (ICR, Fulham)
• Other members of the supervisory team: Dr Steve Pettitt (ICR), Prof Chris Lord (ICR)
• Primary Division or Faculty: Breast Cancer Research Division
• Primary Team or Department: Target Validation & DNA Damage Response

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Project 15 – Mechanistic exploration of cell-free tumour DNA (ctDNA) shedding into circulation using microfluidic vascularised organoid-on-chip models

• Primary Supervisor: Prof Nicola Valeri (Imperial)
• Other members of the supervisory team: Dr Sam Au (Imperial), Prof Valeri (Imperial), Dr Au (Imperial)
• Primary Division or Faculty: Faculty of Medicine, Division of Surgery and Cancer
• Primary Team or Department: Cancer

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