Research Interests

Tumour Dormancy and Relapse

1 - Investigating changes in tumour tissue organisation and architecture during late-stage tumour growth and evolution: implications for cell survival and therapeutic response.

Figure 1.  Changes in tumour tissue architecture and organisation relating to late-stage disease can be modelled ex vivo.

2 - Investigating clonal tumour cell evolution within solid tumours and the impact on the overall response to therapy.

3 - Investigating the role of clonal evolution in the etiology of disease relapse.

Figure 2.  Her2-positive tumours give rise to aggressive Her2-/CK14+ tumours after long latency, in an in vivo model of metastatic disease relapse.

Find out more about Dr Don White's Research on the Breakthrough Breast Cancer Website