Research Study

The Breast and Ovarian Cancer Susceptibility (BOCS) Study

Information for Professionals

Welcome to the Breast and Ovarian Susceptibility (BOCS) Study. The purpose of this study is to identify the genetic factors involved in causing breast and/or ovarian cancer. The DNA from participants and their relatives are used in research involving genetic technologies such as next-generation sequencing to identify and characterise genetic factors that predispose to breast and ovarian cancer. We also do detailed analysis of genetic factors to establish the clinical associations and to make recommendations for implementation and utilisation in clinical practice. We have already identified several genes and genetic variants that predispose to these cancers. Our discoveries provide insights into the biological pathways involved in development of cancer as well as information to improve diagnosis and management of patients and their families and potentially provide new targets for treatment and prevention.

Protocol

Protocol version 3, dated June 2012

Study documents required for patient recruitment

Family Referral Form

Patient Information Sheet

Consent Form

Enquiries

Margaret Warren-Perry PhD
Institute of Cancer Research
15 Cotswold Road, Sutton, Surrey SM2 5NG
Phone: 0208 722 4377
Fax: 0208 722 4359
Email: bocs@icr.ac.uk

Principal Investigators
Professor Nazneen Rahman

MREC: MREC/01/2/18
NIHR CRN Study ID: 6542