Research Interests

The Identification of Recurrent Genomic Alterations 

Our interests lie in the identification of recurrent genomic alterations that are associated with different subtypes of breast cancer. We achieve this using bioinformatics analysis of publicly available next generation sequencing data, and through collaborative efforts with teams both within and external to the ICR. We are also interested in developing mathematical models to identify and predict ‘driver’ events.

The team is also interested in the development of in vitro models to test whether specific mutations and fusion genes drive tumorigenesis. Additionally we aim, through the use high-throughput functional siRNA and chemical compound screens, to identify synthetic lethal genetic interactions with these alterations. This allows us to then identify novel therapies that can be used to treat patients with these specific mutations/fusion genes.

The functional genomics laboratory is primarily funded by Breast Cancer Campaign.