Research Interest
Haemopoietic Stem Cell Transplantation
Our clinical outlet at the Royal Marsden Hospital is one of the largest stem cell transplant units in the UK with dedicated impatient and outpatient facilities. We use autologous stem cells as well as alterative donor sources, including cord blood transplants.
Personalising allogeneic transplant therapy is an important aim and we are investigating in collaboration with the Anthony Nolan Trust, strategies to enable us to select the most appropriate donor based on genetic matching and the most appropriate source of stem cells, be it sibling matched, unrelated or cord blood.
A key outcome in such a strategy, are the rates of GVHD and we are working on strategies to overcome this, the clinical role of the graft versus leukaemia effects and its ability to modulate the level of residual disease after transplant is being investigated.
Team members
Dr Bronwen Shaw, Consultant Haematologist
Dr Mike Potter, Consultant Haematologist
Dr Mark Ethell, Consultant Haematologist
Dr Ann Smith, Head of Stem Cell Transplant Laboratory
Mrs Janet Wells, Deputy Head and Quality Officer
Mr Luke Matthews, Senior Biomedical Scientist
Mrs Trish McDonald, Biomedical Scientist
Ms Stephanie Ingleton, Biomedical Scientist
Miss Lucy Compton, Trainee Biomedical Scientist
Mr Richard Hudson, Medical Laboratory Assistant
Molecular Haematology Team
The focus of the research by this team is the development of personalised medicine strategies for the blood cancers, including myeloma, leukaemia and the lymphomas. This approach is based on the characterisation of the basic pathogenic mechanisms leading to the aetiology and progression, together with the utilisation of this information, to design and implement new therapeutics.
