Research Interests Overview
Although ubiquitylation may regulate protein function through conformational changes, the most common mode of regulation by Ub-conjugation involves specific “Ub-receptors” that recognise ubiquitylated proteins and link them to downstream biochemical processes.
Investigating the molecular mechanism through which IAPs block caspases.
Clinical studies indicate a link between cancer and infectious agents as well as chronic inflammatory disorders. It is thought that infectious agents or inflammatory disorders lead to activation of NF-κB, resulting in production of growth and survival factors that stimulate cancer. Thus, activation of NF-κB seems to cause inflammation-induced tumour growth and progression.
Studying the mechanism of how the Ub conjugation and deconjugation system impacts on cell survival.
Systematic analysis of putative components of the Drosophila cell death machinery and innate immune response
Identifying new cell death regulators.
Investigating IAP-binding proteins to identify novel IAP-regulatory proteins.
Ubiquitin-Mediated Regulation of Apoposis Team
The key aim of the lab is to elucidate how the ubiquitin-message is used as a versatile tool to modulate the cellular response to apoptosis.