Research Interests

A Prospective Observational Study of Outcome and Survival Endpoints in BRCA1/2 Gene Carriers who have Undergone Prophylactic Surgery (the PROSE Study)

We are determining the incidence of cancer after prophylactic breast and ovarian surgery and its psychological implications. Initial studies have shown that such surgery reduces cancer risk by 90% in BRCA1/2 mutation carriers and prophylactic ovarian removal before 50 years halves the risk of a new primary breast cancer. Further follow up is in progress.

Investigators: RA Eeles, E Bancroft; in collaboration with G Gui, F MacNeill, Members of the  Breast Unit; T Ind, D Barton;  Gynaecology Unit; T Rebbeck, Philadelphia, USA
External Funding: NIH