Research Interest

Genetic variability of normal tissue response: radiogenomics

We aim in collaborative studies to assess the genetic component of radiosensitivity in prostate cancer patients treated in radiotherapy trials and link findings with DVH data in prostate cancer.  

Six-hundred and fifty prostate cancer patients (350 from ICR/RMH) have been entered into the collaborative RAPPER study to evaluate target SNP association with the  development of radiation related toxicity.  

Funding has been gained to expand the series to 8000 patients and to undertake a genome-wide search (collaborating centres: Christie, Cambridge, ICR/RMH). Once completed we aim to correlate any genetic tendency to radiation-related side-effects with dose-volume parameters in patients who have contributed to both data-sets using the statistical techniques developed to provide a combined physical/biological prediction of outcome.