Research Interests
Discovery and Development of Kinase Inhibitors as Anticancer Drugs
- Signal Transduction Kinase Projects
- Cell Cycle Kinase Projects
Discovery and Development of Inhibitors of Cellular Stress Responses
Quality control of protein folding, trafficking and degradation is vital to the survival of cells. Tumour cells are especially dependent on molecular chaperones and related proteins that regulate protein homeostasis.
New Screening Libraries for Anticancer Drug Discovery
- Kinase Targeted Libraries: New Macrocycles as Scaffolds for Selective and Multi-targeted Kinase Inhibitors
- Kinase Targeted Libraries: Novel Pyrazolopyridones Inspired by Indirubin
- Kinase Targeted Libraries: Protein Kinase Inhibitor Libraries Based on Azaspirocycles
- Diversity-Oriented Libraries: Design and Screening of a Library of Cembranoid Analogues
Identification of the Cellular Targets of Inhibitors of Androgen Receptor Activity
The androgen receptor (AR) is a nuclear receptor transcription factor important in the development and progression of prostate cancer, including aggressive hormone-refractory tumours.
Screening Libraries for Anticancer Drug Discovery
Ongoing projects on the design and preparation of medium-sized libraries of novel, lead-like and drug-like compounds.
