Research Interests

Objective Target Prioritisation for Cancer Drug Discovery

A major problem often encountered in drug discovery is the abundance of biologically tantalizing targets that end up difficult to progress into useful drugs. These problems can be due to inherent ‘undruggability’ of a particular target, problems with the chemical matter that can be developed for it, or severe issues with selectivity.

3-D Structural Analysis

The ICR boasts some of the best structural biology teams in the world which are solving large numbers clinically relevant structures and complexes, enhancing our ability to use 3D structure information for drug discovery.

Druggable protein networks

Building on the strengths of networks and systems biology at the ICR, we are interested in novel paradigms for the chemical and functional annotation of protein interaction networks. These aim to allow us to fully utilise the benefit gained from the broad systems biology community, and address the 'druggability of networks' rather than individual targets. We are developing network annotation and exploration paradigms to enable scientists in drug discovery to map and navigate paths through complex interaction networks and identify novel drug targets for cancer.