Biology of Childhood Leukaemia
Team Leader: Professor Mel Greaves FRS
Location: Brookes-Lawley Building, Sutton
Section: Section of Haemato-Oncology
Our LRF specialist programme-funded research seeks to uncover the pre-clinical natural history and aetiology of major subtypes of paediatric leukaemia: childhood acute lymphoblastic leukaemia (with TEL-AML1 gene fusion or hyperdiploidy) and infant acute leukaemias (with MLL gene fusions). Individual projects in the portfolio are designed to endorse developmental models for these leukaemias involving pre-natal initiation.
We have an extensive network of UK-based and international collaborators providing access to patient samples. Our epidemiological interests are pursued via the UK Children’s Cancer Study Group (UKCCS) and via international cooperation (e.g. Brazil and Hong Kong).
Key Review References to Team’s Work:
Greaves, MF (2006) Infection, immune responses and the aetiology of childhood leukaemia. Nature Reviews Cancer, 6: 193-203
Greaves MF, Maia AT, Wiemels JL, Ford AM (2003) Leukemia in twins: lessons in natural history. Blood, 102: 2321-2333
Greaves MF, Wiemels J (2003) Origins of chromosome translocations in childhood leukaemia. Nature Reviews Cancer, 3: 639-649
In the Section of Haemato-Oncology
