Protein Networks Team
Team Leader: Dr Paul Huang
Location: Chester Beatty Laboratories, London
Section: Section of Cell and Molecular Biology including the Cancer Research UK Tumour Cell Signalling Unit
The Protein Networks team is a new laboratory in the section whose focus is to elucidate the protein phosphorylation networks that regulate complex cancer phenotypes such as chemoresistance and tumour progression. The primary tool that the lab employs to map signaling networks is mass spectrometry – a powerful technique that allows for the unbiased identification and quantification of well-established and novel phosphorylation sites (phosphoproteomics) with exquisite sensitivity over a large dynamic range. Through the use of biochemical techniques and phosphoproteomics, we aim to:
1. Understand how signaling networks adapt to changes in their microenvironment and in response to chemotherapy
2. Determine the mechanistic basis of signal integration downstream of multiple extracellular cues
3. Explore how network information can be harnessed to develop novel therapeutic strategies for cancer
In the Section of Cell and Molecular Biology including the Cancer Research UK Tumour Cell Signalling Unit
