Nuclear Oncogene Team
Team Leader:
Dr Kathy Weston
Location: Chester Beatty Laboratories, London
Work in our lab centres on the function of the MYB oncogene in normal and neoplastic growth. The MYB protein is a transcription factor which can activate target genes with vital roles in the development of normal tissue, particularly blood cells, and also in the maintenance of the cancerous state. Our research uses two systems to investigate how MYB works: T cell development, with an emphasis on early events taking place in the thymus, and oesophageal cancer. In both these systems, perturbing MYB activity has profound effects, and our goal in the lab is to understand completely the network of signalling pathways and target genes which MYB uses to mediate these effects.
In the Section of Cell and Molecular Biology (including the Cancer Research UK Centre for Cell and Molecular Biology)
