The Institute of Cancer Research

National Study of Colorectal Cancer Genetics (NSCCG)

Molecular and Population Genetics Team

Section: Section of Cancer Genetics

 

Welcome to the homepage of the National Study of Colorectal Cancer Genetics (NSCCG).  The purpose of this study is to collect information from individuals and from families with a family history of colorectal cancer, so that we can try and identify new hereditary factors (genes) that may lead to the development of colorectal cancer and further increase our understanding of why this condition develops and perhaps provide new targets for chemotherapy. 

 

Study Type: Observational    REC no: MREC/02/0/97

Disease: Caecum; Colon; Rectum

Design Type: Genetic Epidemiology

Phase: This study is open to additional centres, and is SSA exempt.

Closure Date: 30/09/2010

Sample Size: 20,000

Inclusion Criteria: Patients aged 18-69 at date of diagnosis, who have had a diagnosis of adenocarcinoma of the colon or rectum within the last five years. Controls will be non-blood relatives or friends of cases

Exclusion Criteria: Patients will be excluded if they do not meet the inclusion criteria. Controls will be excluded if they have a past or present history of cancer.

Chief Investigators: Professors Richard Gray, Richard Houlston, Julian Peto                   

 

Further details please contact:

Mr Steven Penegar
Institute of Cancer Research
Section of Cancer Genetics
15 Cotswold Road
Sutton
SM2 5NG

Tel:020 8722 4471
Fax: 0208 722 4011

Email: Nsccg.Study@icr.ac.uk
Funders: Digestive Disorders Foundation, CTAAC
Sponsor: Institute of Cancer Research, Surrey

 

There are a number of documents that are required as part of the registration for recruiting sites for NSCCG. These include supporting documents for ethical approval and information documents about the study. They can be downloaded using the links below.

 

List of Documents required for Site set-up: 

 

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List of Current Study Documents. Amendment information available by request to Nsccg.Study@icr.ac.uk

 

 

Our current Newsletter for Research Nurses can be found below:

 

Publications:

Webb E et al. (2006) Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives. Hum Mol Genet. 15:3263-71

Penegar S et al (2007) National study of colorectal cancer genetics. Br J Cancer. 2007 Nov 5;97(9):1305-9. Epub 2007 Sep 25.