Urological Cancer Clinical Trials

Open to recruitment

111 Trial: The 111 trial is a single group trial evaluating one cycle of adjuvant BEP chemotherapy in high risk, stage 1 non-seminomatous germ cell tumours of the testis (NSGCTT).

BOXIT: This trial is a randomised phase III multi-centre double-blind placebo-controlled clinical trial.  The primary objective is to determine if the addition of the oral COX-2 inhibitor celecoxib to standard therapy is more effective in terms of disease recurrence at 3 years compared to standard therapy alone for the treatment of superficial TCC of the bladder in intermediate and high risk patients.

LopeRA: LopeRA is a randomised controlled trial of laparoscopic, open and robot assisted prostatectomy as treatment for organ-confined prostate cancer.

PIVOTAL: PIVOTAL - A randomised phase II trial of Prostate and pelvIs versus prOstaTe Alone treatment for Locally advanced prostate cancer. 

In set-up

POUT: Peri-Operative chemotherapy or sUrveillance in upper Tract urothelial cancer

In active follow-up

BC2001: A randomised phase III study of radiotherapy with and without synchronous chemotherapy in muscle invasive bladder cancer.

CHHiP: Conventional or Hypofractionated High Dose Intensity Modulated Radiotherapy for Prostate Cancer

Intercontinental: Intercontinental is an international phase III randomised trial comparing intermittent versus continuous androgen suppression for patients with prostate-specific-antigen progression in the clinical absence of distant metastases following radiotherapy for prostate cancer.

Penile TPF: A Phase II Trial of docetaxel, cisplatin & 5-fluorouracil chemotherapy (TPF) in locally advanced and metastatic carcinoma of the penis

ProSTART: A Pilot Study for a Phase III Clinical Trial in Patients with Favourable Risk Prostate Cancer Comparing Active Surveillance Therapy Against Radical Treatment

SPARE: Randomised trial of Selective bladder Preservation Against Radical Excision (cystectomy) in muscle invasive T2/T3 transitional cell carcinoma of the bladder – feasibility study.