IMPORT LOW

Disease site: Breast Cancer

Treatment Modality: Radiotherapy

Status: In active follow-up

Randomised trial testing intensity modulated and partial organ radiotherapy following breast conservation surgery for early breast cancer. IMPORT LOW

IMPORT LOW tests partial breast radiotherapy (RT) in a group of women with early breast cancer who are at a low risk of local tumour recurrence. The trial compares a standard dose of RT delivered to the whole breast in 15 fractions over 3 weeks, with two different test arms delivering less radiotherapy to the whole breast and a standard dose to the partial breast, or no RT to the whole breast and a standard dose to the partial breast. The reduced RT to the whole breast in the test arms reflects the fact that the risk of true local recurrence is highest in the area of the breast close to the site of the original tumour. The trial tests whether this reduction in dose to the whole breast preserves the physical appearance of the breast and reduces the side effects of RT, whilst maintaining cancer cure.

IMPORT LOW opened in May 2007 and entered the first patient in the same month. The trial closed to recruitment on 30th September 2010 with 2018 patients.