ICCG FEMTX Trial

Disease site: Other Cancers

Treatment Modality: Surgery

Status: In active follow-up

The aim of this study was to investigate in patients who underwent radical resection for gastric cancer the relative efficacy of 5-Fluorouracil combined with epirubicin vs control. This trial was open to patients of up to 71 years old; with histologically proven adenocarcinoma of the stomach or distal oesophagus (oesophago-gastric junction with cardias involvement) for which curative surgery was performed, and disease stage T2, T3, T4, or T1 with histologically confirmed lymph node involvement (i.e. stage II & III).  

191 patients were randomised from 16 ICCG centres.

This study has been analysed in collaboration with the EORTC study of FAMTX vs Control (206 patients from 23 EORTC centres).

No significant differences in disease-free or overall survival were seen between the FEMTX/FAMTX and control arms.

This is an International Collaborative Cancer Group (ICCG) trial (C/7/89).

Publication

Coombes, Vigushin, Kanfer et al, 2003. Proceedings of ASCO Annual Meeting pp131a. Randomised Trial of High Dose Therapy using cyclophosphamide, thiotepa and carboplatin in primary breast cancer patients with 4 or more histologically involved positive nodes.