Professor David Dearnaley joined the Academic Unit of Radiotherapy at The Royal Marsden (RMH) and The Institute of Cancer Research (ICR) as Bob Champion Senior Lecturer and Honorary Consultant in 1987. He subsequently became Reader in Prostate Cancer Studies in 1999 and Professor of Uro-Oncology in 2003.
He was Head of The Royal Marsden Urology Unit from 1994 to 2006 and Chairman of RMH and ICR Committee for Clinical Research 2006 - 2013. He is the Prostate Theme Lead for RMH/ICR Biomedical Research Centre. He was appointed an NIHR Senior Investigator in 2008 and is a member of the NHS R&D HTA Clinical Trials Board College of Experts (2012-). He has previously chaired both the MRC and NCRI Prostate Study Groups, as well as the MRC Radiotherapy Clinical Trials Group.
Principal areas of research have been in the development of conformal (CFRT), intensity modulated (IMRT), image-guided (IGRT) and hypofractionated radiotherapy treatments for prostate cancer. He has led phase III randomised trials to establish these in clinical practice and dose escalated CFRT has been incorporated in NICE guidance. Presently he leads associate translational programmes into the biophysics, radiogenomics and molecular pathology of radiation response and toxicity.