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Pettitt, S.J. Shao, N. Zatreanu, D. Frankum, J. Bajrami, I. Brough, R. Krastev, D.B. Roumeliotis, T.I. Choudhary, J.S. Lorenz, S. Rust, A. de Bono, J.S. Yap, T.A. Tutt, A.N. Lord, C.J. (2023). A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant. Oncogene, Vol.42 (36), pp. 2701-2709.  show abstract  full text

Krastev, D.B. Li, S. Sun, Y. Wicks, A.J. Hoslett, G. Weekes, D. Badder, L.M. Knight, E.G. Marlow, R. Pardo, M.C. Yu, L. Talele, T.T. Bartek, J. Choudhary, J.S. Pommier, Y. Pettitt, S.J. Tutt, A.N. Ramadan, K. Lord, C.J. (2022). The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. Nat cell biol, Vol.24 (1), pp. 62-73.  show abstract  full text

Llorca-Cardenosa, M.J. Aronson, L.I. Krastev, D.B. Nieminuszczy, J. Alexander, J. Song, F. Dylewska, M. Broderick, R. Brough, R. Zimmermann, A. Zenke, F.T. Gurel, B. Riisnaes, R. Ferreira, A. Roumeliotis, T. Choudhary, J. Pettitt, S.J. de Bono, J. Cervantes, A. Haider, S. Niedzwiedz, W. Lord, C.J. Chong, I.Y. (2022). SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance. Cancer res, Vol.82 (21), pp. 3962-3973.  show abstract  full text

Rouleau-Turcotte, É. Krastev, D.B. Pettitt, S.J. Lord, C.J. Pascal, J.M. (2022). Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol cell, Vol.82 (16), pp. 2939-2951.e5.  show abstract  full text

Bajrami, I. Walker, C. Krastev, D.B. Weekes, D. Song, F. Wicks, A.J. Alexander, J. Haider, S. Brough, R. Pettitt, S.J. Tutt, A.N. Lord, C.J. (2021). Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency. Commun biol, Vol.4 (1), p. 1270.  show abstract  full text

Zandarashvili, L. Langelier, M.-. Velagapudi, U.K. Hancock, M.A. Steffen, J.D. Billur, R. Hannan, Z.M. Wicks, A.J. Krastev, D.B. Pettitt, S.J. Lord, C.J. Talele, T.T. Pascal, J.M. Black, B.E. (2020). Structural basis for allosteric PARP-1 retention on DNA breaks. Science, Vol.368 (6486).  show abstract

Chabanon, R.M. Muirhead, G. Krastev, D.B. Adam, J. Morel, D. Garrido, M. Lamb, A. Hénon, C. Dorvault, N. Rouanne, M. Marlow, R. Bajrami, I. Cardeñosa, M.L. Konde, A. Besse, B. Ashworth, A. Pettitt, S.J. Haider, S. Marabelle, A. Tutt, A.N. Soria, J.-. Lord, C.J. Postel-Vinay, S. (2019). PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. J clin invest, Vol.129 (3), pp. 1211-1228.  show abstract  full text

Touat, M. Sourisseau, T. Dorvault, N. Chabanon, R.M. Garrido, M. Morel, D. Krastev, D.B. Bigot, L. Adam, J. Frankum, J.R. Durand, S. Pontoizeau, C. Souquère, S. Kuo, M.-. Sauvaigo, S. Mardakheh, F. Sarasin, A. Olaussen, K.A. Friboulet, L. Bouillaud, F. Pierron, G. Ashworth, A. Lombès, A. Lord, C.J. Soria, J.-. Postel-Vinay, S. (2018). DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J clin invest, Vol.128 (4), pp. 1671-1687.  show abstract  full text

Bajrami, I. Marlow, R. van de Ven, M. Brough, R. Pemberton, H.N. Frankum, J. Song, F. Rafiq, R. Konde, A. Krastev, D.B. Menon, M. Campbell, J. Gulati, A. Kumar, R. Pettitt, S.J. Gurden, M.D. Cardenosa, M.L. Chong, I. Gazinska, P. Wallberg, F. Sawyer, E.J. Martin, L.-. Dowsett, M. Linardopoulos, S. Natrajan, R. Ryan, C.J. Derksen, P.W. Jonkers, J. Tutt, A.N. Ashworth, A. Lord, C.J. (2018). E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer. Cancer discov, Vol.8 (4), pp. 498-515.  show abstract  full text

Noordermeer, S.M. Adam, S. Setiaputra, D. Barazas, M. Pettitt, S.J. Ling, A.K. Olivieri, M. Álvarez-Quilón, A. Moatti, N. Zimmermann, M. Annunziato, S. Krastev, D.B. Song, F. Brandsma, I. Frankum, J. Brough, R. Sherker, A. Landry, S. Szilard, R.K. Munro, M.M. McEwan, A. Goullet de Rugy, T. Lin, Z.-. Hart, T. Moffat, J. Gingras, A.-. Martin, A. van Attikum, H. Jonkers, J. Lord, C.J. Rottenberg, S. Durocher, D. (2018). The shieldin complex mediates 53BP1-dependent DNA repair. Nature, Vol.560 (7716), pp. 117-121.  show abstract  full text

Pettitt, S.J. Krastev, D.B. Brandsma, I. Dréan, A. Song, F. Aleksandrov, R. Harrell, M.I. Menon, M. Brough, R. Campbell, J. Frankum, J. Ranes, M. Pemberton, H.N. Rafiq, R. Fenwick, K. Swain, A. Guettler, S. Lee, J.-. Swisher, E.M. Stoynov, S. Yusa, K. Ashworth, A. Lord, C.J. (2018). Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nat commun, Vol.9 (1), p. 1849.  show abstract  full text

Aleksandrov, R. Dotchev, A. Poser, I. Krastev, D. Georgiev, G. Panova, G. Babukov, Y. Danovski, G. Dyankova, T. Hubatsch, L. Ivanova, A. Atemin, A. Nedelcheva-Veleva, M.N. Hasse, S. Sarov, M. Buchholz, F. Hyman, A.A. Grill, S.W. Stoynov, S.S. (2018). Protein Dynamics in Complex DNA Lesions. Mol cell, Vol.69 (6), pp. 1046-1061.e5.  show abstract

Krastev, D.B. Pettitt, S.J. Campbell, J. Song, F. Tanos, B.E. Stoynov, S.S. Ashworth, A. Lord, C.J. (2018). Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets. Nat commun, Vol.9 (1), p. 2016.  show abstract  full text

Pettitt, S.J. Krastev, D.B. Pemberton, H.N. Fontebasso, Y. Frankum, J. Rehman, F.L. Brough, R. Song, F. Bajrami, I. Rafiq, R. Wallberg, F. Kozarewa, I. Fenwick, K. Armisen-Garrido, J. Swain, A. Gulati, A. Campbell, J. Ashworth, A. Lord, C.J. (2017). Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells. Sci data, Vol.4, p. 170020.  show abstract  full text

Jones, S.E. Fleuren, E.D. Frankum, J. Konde, A. Williamson, C.T. Krastev, D.B. Pemberton, H.N. Campbell, J. Gulati, A. Elliott, R. Menon, M. Selfe, J.L. Brough, R. Pettitt, S.J. Niedzwiedz, W. van der Graaf, W.T. Shipley, J. Ashworth, A. Lord, C.J. (2017). ATR Is a Therapeutic Target in Synovial Sarcoma. Cancer res, Vol.77 (24), pp. 7014-7026.  show abstract  full text

Caldarelli, A. Müller, J.P. Paskowski-Rogacz, M. Herrmann, K. Bauer, R. Koch, S. Heninger, A.K. Krastev, D. Ding, L. Kasper, S. Fischer, T. Brodhun, M. Böhmer, F.-. Buchholz, F. (2013). A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling. Leukemia, Vol.27 (12), pp. 2301-2310.  show abstract

Kappei, D. Butter, F. Benda, C. Scheibe, M. Draškovič, I. Stevense, M. Novo, C.L. Basquin, C. Araki, M. Araki, K. Krastev, D.B. Kittler, R. Jessberger, R. Londoño-Vallejo, J.A. Mann, M. Buchholz, F. (2013). HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Embo j, Vol.32 (12), pp. 1681-1701.  show abstract  full text

Krastev, D.B. Slabicki, M. Paszkowski-Rogacz, M. Hubner, N.C. Junqueira, M. Shevchenko, A. Mann, M. Neugebauer, K.M. Buchholz, F. (2011). A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Nat cell biol, Vol.13 (7), pp. 809-818.  show abstract

Gospodinov, A. Vaissiere, T. Krastev, D.B. Legube, G. Anachkova, B. Herceg, Z. (2011). Mammalian Ino80 mediates double-strand break repair through its role in DNA end strand resection. Mol cell biol, Vol.31 (23), pp. 4735-4745.  show abstract

Krastev, D.B. Buchholz, F. (2011). Ribosome biogenesis and p53: who is regulating whom?. Cell cycle, Vol.10 (20), pp. 3417-3418.

Słabicki, M. Theis, M. Krastev, D.B. Samsonov, S. Mundwiller, E. Junqueira, M. Paszkowski-Rogacz, M. Teyra, J. Heninger, A.-. Poser, I. Prieur, F. Truchetto, J. Confavreux, C. Marelli, C. Durr, A. Camdessanche, J.P. Brice, A. Shevchenko, A. Pisabarro, M.T. Stevanin, G. Buchholz, F. (2010). A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. Plos biol, Vol.8 (6), p. e1000408.  show abstract

Kraeva, R.I. Krastev, D.B. Roguev, A. Ivanova, A. Nedelcheva-Veleva, M.N. Stoynov, S.S. (2007). Stability of mRNA/DNA and DNA/DNA duplexes affects mRNA transcription. Plos one, Vol.2 (3), p. e290.  show abstract

Nedelcheva-Veleva, M.N. Krastev, D.B. Stoynov, S.S. (2006). Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways. Nucleic acids res, Vol.34 (15), pp. 4138-4146.  show abstract

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