Our publications
‘Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery’ – Manjuan Liu, Amin Mirza, P. Craig McAndrew, Arjun Thapaliya, Olivier A. Pierrat, Mark Stubbs, Tamas Hahner, Nicola E. A. Chessum, Paolo Innocenti, John Caldwell, Matthew D. Cheeseman, Benjamin R. Bellenie, Rob L. M. van Montfort, Gary K. Newton, Rosemary Burke, Ian Collins & Swen Hoelder. Journal of Medicinal Chemistry, 2023. DOI: 10.1021/acs.jmedchem.3c00758.
‘A degron blocking strategy towards improved CRL4CRBN recruiting PROTAC selectivity’ – Habib Bouguenina, Andrea Scarpino, Jack O'Hanlon, Justin Warne, Hannah Z. Wang, Laura Chan Wah Hak, Amine Sadok, P. Craig McAndrew, Mark Stubbs, Olivier A. Pierrat, Tamas Hahner, Marc P. Cabry, Yann-Vai Le Bihan, Costas Mitsopoulos, Fernando Jr. Sialana, Theodoros I. Roumeliotis, Rosemary Burke, Rob L.M. Van Montfort, Jyoti Choudhary, Rajesh Chopra, John J. Caldwell & Ian Collins – ChemBioChem, 2023, e202300351.
‘iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells’ – Habib Bouguenina, Stephanos Nicolaou, Yann-Vaï Le Bihan, Elizabeth A. Bowling, Cheyenne Calderon, John J. Caldwell, Brinley Harrington, Angela Hayes, P. Craig McAndrew, Costas Mitsopoulos, Fernando Jr. Sialana, Andrea Scarpino, Mark Stubbs, Arjun Thapaliya, Siddhartha Tyagi, Hannah Z. Wang, Francesca Wood, Rosemary Burke, Florence Raynaud, Jyoti Choudhary, Rob L.M. van Montfort, Amine Sadok, Thomas F. Westbrook, Ian Collins & Rajesh Chopra – iScience, 2023, 26(7), 107059.
‘Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo’ – Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. de Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby de Klerk, Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie & Swen Hoelder – Journal of Medicinal Chemistry, 2022, 65(12), 8191-8207.
‘Encoding BRAF inhibitor functions in protein degraders’ – Daniel S. J. Miller, Sabine A. Voell, Izidor Sosic, Matic Proj, Olivia W. Rossanese, Gregor Schnakenburg, Michael Gutschow, Ian Collins & Christian Steinebach - RSC Medicinal Chemistry, 2022, 13, 731-736.
‘Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays’ - Olivier A. Pierrat, Manjuan Liu, Gavin W. Collie, Kartika Shetty, Matthew J. Rodrigues, Yann-Vaï Le Bihan, Emma A. Gunnell, P. Craig McAndrew, Mark Stubbs, Martin G. Rowlands, Norhakim Yahya, Erald Shehu, Rachel Talbot, Lisa Pickard, Benjamin R. Bellenie, Kwai-Ming J. Cheung, Ludovic Drouin, Paolo Innocenti, Hannah Woodward, Owen A. Davis, Matthew G. Lloyd, Ana Varela, Rosemary Huckvale, Fabio Broccatelli, Michael Carter, David Galiwango, Angela Hayes, Florence I. Raynaud, Christopher Bryant, Steven Whittaker, Olivia W. Rossanese, Swen Hoelder, Rosemary Burke & Rob L. M. van Montfort – Scientific Reports, 2022, 12, article number 18633.
‘Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators’ – Nil Ege, Habib Bouguenina, Marianthi Tatari & Rajesh Chopra – Cell Chemical Biology, 2021, 28(3), 283-299.
‘A critical evaluation of the approaches to targeted protein degradation for drug discovery’ – Rajesh Chopra, Amine Sadok & Ian Collins – Drug Discovery Today: Technologies, 2019, 31, 5-13.
‘Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway’ – Ian Collins, Hannah Wang, John J. Caldwell & Rajesh Chopra – Biochemical Journal, 2017, 474(7), 1127-1147.