Study and Careers

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

Under the leadership of Dr Stephen-John Sammut, we are seeking a highly motivated and ambitious postdoctoral researcher to apply existing and develop cutting-edge single-cell computational methods for modelling breast tumour evolution during chemotherapy and immunotherapy. Your work will contribute to the development of predictive frameworks that can be deployed in breast clinical trials to guide treatment decisions. This role offers an outstanding opportunity to drive innovation at the interface of computational biology and clinical research, shaping the future of precision oncology. For general information on Post Doc's at The ICR can be found here. The ICR has a workforce agreement stating that there is a maximum duration of employment of 7 years including pre-ICR PDTF experience. Key Requirements The successful candidate must have a PhD in a computational biology or other numerical subject, have extensive programming experience, and possess a basic knowledge of cancer biology. A background in the analysis and interpretation of molecular data is essential. If available, please include a link to your online, publicly-available source code repository in your application. Department/Directorate Information: The Cancer Dynamics Laboratory headed by Dr Stephen John Sammut, focuses on developing computational and experimental frameworks that model changes in breast cancer biology during treatment to develop personalised precision cancer therapies. The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Centre is directed by Clinician Scientist Professor Andrew Tutt. We encourage all applicants to access the job pack attached for more detailed information regarding this role. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role.

About the team The Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research, in the Division of Breast Cancer Research, is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. The Centre is located in state-of-the-art laboratory space in central London, is supported by excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Director of the Centre is clinician scientist Professor Andrew Tutt. Professor Chris Lord is the Deputy Director and is a cancer biologist. Our work is fully integrated in a programme that Professor Tutt directs with our colleagues in the Breast Cancer Now Unit at King’s College London (KCL Deputy Director Dr. Sheeba Irshad). We also work closely with partners across the ICR and with colleagues in the Royal Marsden Hospital and Guy’s Hospital. About the role Key to our success is the ability to fund the research in the Centre and the Division, either by competitive research grants, or via collaborations with those in the biotech. and pharmaceutical commercial sectors. Enabling, managing and maintaining key collaborations with other academic research groups, both external and within ICR is also key to our success. This role is therefore aimed at providing assistance to the Director, Deputy Directors and Principal Investigators by: Supporting our ongoing relationship with our main funder, Breast Cancer Now, by project managing the submission from the Centre of annual reports and our five year cross-programme grant renewal application Identifing new grant funding opportunities and supporting grant applications Identifying and project managing new commercial opportunities e.g. collaborations with pharma. and biotech. Working with the ICR’s Business and Innovation team to develop research agreements and commercial contracts that support collaborations with pharma. and biotech. Carrying out administrative tasks associated with the use of the selection and acquisition of equipment in collaboration with the Research Centre’s laboratory manager Carrying out administrative tasks associated with the use of scientific core facilities and CROs Carrying out supporting administration that is associated with interactions with scientific collaborators, including our colleagues within ICR, the ICR/Imperial College CRUK Convergence Science Centre, the Breast Cancer Now Research Unit at King’s College London and colleagues in the Royal Marsden Hospital and Guy’s Hospital Assisting with the composition and submission of research manuscripts from the Centre, including liaising with communications teams within ICR and Breast Cancer Now Managing our Patient Representatives programme Managing scientific content on external website pages and on internal wiki pages. Assisting with the implementation of our new laboratory lab management system. (SLIMs) Planning of scientific meetings and any scientific associated tasks that aid the delivery of research in the Centre & Division, including monthly Group Leaders meetings and retreats Key candidate requirements Hold a PhD in a life science subject Extensive knowledge of wet laboratory cancer research gained from working in a cancer research laboratory Knowledge of the academic/charitable industry funding system Knowledge of Cell Biology, Molecular Biology, Cancer Biology Proven scientific communication skills (written and verbal)

Under the guidance of Professor Uwe Oelfke, we are seeking to recruit a Scientific Officer to provide skilled laboratory assistance in pre-clinical projects in radiobiological and immunological research. The successful candidate will provide first line user training and support for our three x-ray radiation devices including performing the monthly quality assurance. They will also be expected to contribute to the design and delivery of on-going research projects. About you The successful candidate must have: A BSc. in Physics or Biomedical Sciences (or equivalent) MSc. in Physics and Engineering or Biomedical Sciences (desirable) A basic knowledge of Matlab, Python or C/C++ The ability to understand and discuss scientific projects Experience of working under pressure and adhering to established deadlines The ability to work independently whilst still being a good team player Excellent organisation skills with attention to detail Department/Directorate Information The Radiotherapy Physics Modelling Team, lead by Professor Uwe Oelfke, sits within the Division of Radiotherapy and Imaging. We are applying cutting edge Radiotherapy techniques in a multi-disciplinary setting to investigate the application of radiation in an in-vitro and in-vivo setting. The postholder will be based within the Centre for Cancer Imaging which houses 130 imaging researchers from a range of disciplines. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. To arrange an informal discussion regarding the role, please email [email protected]